Naslov
Electrical circuit analogy for enzymatic cycle kinetics

Autori
Županović, Paško ; Juretić, Davor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
MATH/CHEM/COMP/2003 The 18-th Dubrovnik International Course & Conference on the Interfaces Among Mathematics, Chemistry and Computer Sciences - Program & Book of Abstracts, Editors: Graovac Ante, Pokrić Biserka and Smrečki Vilko / Graovac, Ante ; Pokrić, Biserka ; Smrečki, Vilko - Zagreb : Institut Ruđer Bošković, 2003

Skup
MATH/CHEM/COMP/2003 The 18-th Dubrovnik International Course & Conference on the Interfaces Among Mathematics, Chemistry and Computer Sciences

Mjesto i datum
Dubrovnik, Hrvatska, 23.06.2003. - 28.06.2003

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
free-energy transduction; enzymatic kinetics; electrical circuit analogy

Sažetak
A free-energy transducing macromolecule, interacting with ligands, and cycling through discrete states, can be described by the Hill's diagram. Close to equilibrium, where linear flčux-force relationship hold, we develop a method of the construction of the electrical circuit corresponding to the Hill's diagram. The Thevenin's theorem is used to find the efficiency of free-energy transduction. Maximal power transfer conditions are then found too. The method of the mesh currents is used to give an alternate, much more elegant proof of the Jean's theorem from 1923. Assuming fixed ligand concentrations, we prove by means of the Jean's theorem, that fluxes in the steady state enzymatic cycle kinetics, distribute themselves to make the entropy production maximal.

Izvorni jezik
Engleski

Znanstvena područja
Fizika

POVEZANOST RADA