Naslov
Role of a poison control center in toxicovigilance related to antidote treatment

Autori
Babić, Željka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
42nd International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) 24-27 May 2022, Tallinn, Estonia / - : Clinical Toxicology, 2022, 78-78

Skup
42nd International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT 2022)

Mjesto i datum
Talin, Estonija; online, 24.05.2022. - 27.05.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
antidotes ; poison control

Sažetak
Data on the characteristics of cases involving pharmaceutical antidote treatment was extracted from the electronic system established in August 2021 for storing data from telephone consultations with the Croatian Poison Control Centre. All available records included (August-October 2021, 693 cases in total). In the study period, there were 59 cases of benzodiazepine ingestion (flumazenil was indicated in 11 of them, 19%), 12 cases of opioid misuse (naloxone was indicated in 7, 58%), and 16 cases of paracetamol ingestion (NAC, was indicated in 3 cases, 19%). Flumazenil and naloxone were readily available for treatment. At the time of the call, flumazenil was already administered in 8 of 11 indicated cases (73%), and naloxone in 5 of 7 indicated cases (71%). In four of 11 cases (36%) in which flumazenil was indicated, patients ingested additional psychoactive medications with potential for inducing seizures in overdose. Regarding naloxone, in one case of intravenous heroin overdose recurring toxicity was observed despite initial boluses of naloxone followed by continuous infusion. In another three cases involving long-acting opioids (buprenorphine and methadone), repeated or continuous dosing of naloxone in a case of symptom reoccurrence was recommended. Regarding NAC, in all three cases in which it was indicated based on reported paracetamol dose (which was planned to be confirmed by serum paracetamol determination in two cases), NAC treatment was not initiated by the time of the call.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA