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Pregled bibliografske jedinice broj: 1252371

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

(23and Me Res Team ; eQTLgen Consortium ; Int Cannabis Consortium ; Soc Sci Genetic Association Con) Karlsson Linnér, Richard; 23and Me Research Team; Biroli, Pietro; Kong, Edward; Meddens, S. Fleur W.; Wedow, Robbee; Fontana, Mark Alan; Lebreton, Maël; Tino, Stephen P.; Abdellaoui, Abdel et al.
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences // Nature Genetics, 51 (2019), 2; 245-257 doi:10.1038/s41588-018-0309-3 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1252371 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Autori
Karlsson Linnér, Richard ; 23and Me Research Team ; Biroli, Pietro ; Kong, Edward ; Meddens, S. Fleur W. ; Wedow, Robbee ; Fontana, Mark Alan ; Lebreton, Maël ; Tino, Stephen P. ; Abdellaoui, Abdel ; Hammerschlag, Anke R. ; Nivard, Michel G. ; Okbay, Aysu ; Rietveld, Cornelius A. ; Timshel, Pascal N. ; Trzaskowski, Maciej ; Vlaming, Ronald de ; Zünd, Christian L. ; Bao, Yanchun ; Buzdugan, Laura ; Caplin, Ann H. ; Chen, Chia-Yen ; Eibich, Peter ; Fontanillas, Pierre ; Gonzalez, Juan R. ; Joshi, Peter K. ; Karhunen, Ville ; Kleinman, Aaron ; Levin, Remy Z. ; Lill, Christina M. ; Meddens, Gerardus A. ; Muntané, Gerard ; Sanchez-Roige, Sandra ; Rooij, Frank J. van ; Taskesen, Erdogan ; Wu, Yang ; Zhang, Futao ; Auton, Adam ; Boardman, Jason D. ; Clark, David W. ; Conlin, Andrew ; Dolan, Conor C. ; Fischbacher, Urs ; Groenen, Patrick J. F. ; Harris, Kathleen Mullan ; Hasler, Gregor ; Hofman, Albert ; Ikram, Mohammad A. ; Jain, Sonia ; Karlsson, Robert ; Kessler, Ronald C. ; Kooyman, Maarten ; MacKillop, James ; Männikkö, Minna ; Morcillo-Suarez, Carlos ; McQueen, Matthew B. ; Schmidt, Klaus M. ; Smart, Melissa C. ; Sutter, Matthias ; Thurik, A. Roy ; Uitterlinden, André G. ; White, Jon ; Wit, Harriet de ; Yang, Jian ; Bertram, Lars ; Boomsma, Dorret I. ; Esko, Tõnu ; Fehr, Ernst ; Hinds, David A. ; Johannesson, Magnus ; Kumari, Meena ; Laibson, David ; Magnusson, Patrik K. E. ; Meyer, Michelle N. ; Navarro, Arcadi ; Palmer, Abraham A. ; Pers, Tune H. ; Posthuma, Danielle ; Schunk, Daniel ; Stein, Murray B. ; Svento, Rauli ; Tiemeier, Henning ; Timmers, Paul R. H. J. ; Turley, Patrick ; Ursano, Robert J. ; Wagner, Gert G. ; Wilson, James F. ; Gratten, Jacob ; Lee, James J. ; Cesarini, David ; Benjamin, Daniel J. ; Koellinger, Philipp D. ; Beauchamp, Jonathan P. ; eQTLgen Consortium ; International Cannabis Consortium ; Social Science Genetic Association Consortium

Kolaboracija
23and Me Res Team ; eQTLgen Consortium ; Int Cannabis Consortium ; Soc Sci Genetic Association Con

Izvornik
Nature Genetics (1061-4036) 51 (2019), 2; 245-257

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
GENDER-DIFFERENCES ; GWAS ; DETERMINANTS ; PREFERENCES ; PERSONALITY ; LD

Sažetak
Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated (vertical bar(r) over cap (g)vertical bar similar to 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ivana Kolčić (autor)

Avatar Url Ozren Polašek (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

(23and Me Res Team ; eQTLgen Consortium ; Int Cannabis Consortium ; Soc Sci Genetic Association Con) Karlsson Linnér, Richard; 23and Me Research Team; Biroli, Pietro; Kong, Edward; Meddens, S. Fleur W.; Wedow, Robbee; Fontana, Mark Alan; Lebreton, Maël; Tino, Stephen P.; Abdellaoui, Abdel et al.
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences // Nature Genetics, 51 (2019), 2; 245-257 doi:10.1038/s41588-018-0309-3 (međunarodna recenzija, članak, znanstveni)
(23and Me Res Team ; eQTLgen Consortium ; Int Cannabis Consortium ; Soc Sci Genetic Association Con) (23and Me Res Team, eQTLgen Consortium, Int Cannabis Consortium, Soc Sci Genetic Association Con) Karlsson Linnér, R., 23and Me Research Team, Biroli, P., Kong, E., Meddens, S., Wedow, R., Fontana, M., Lebreton, M., Tino, S. & Abdellaoui, A. (2019) Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nature Genetics, 51 (2), 245-257 doi:10.1038/s41588-018-0309-3.
@article{article, author = {Karlsson Linn\'{e}r, Richard and Biroli, Pietro and Kong, Edward and Meddens, S. Fleur W. and Wedow, Robbee and Fontana, Mark Alan and Lebreton, Ma\"{e}l and Tino, Stephen P. and Abdellaoui, Abdel and Hammerschlag, Anke R. and Nivard, Michel G. and Okbay, Aysu and Rietveld, Cornelius A. and Timshel, Pascal N. and Trzaskowski, Maciej and Vlaming, Ronald de and Z\"{u}nd, Christian L. and Bao, Yanchun and Buzdugan, Laura and Caplin, Ann H. and Chen, Chia-Yen and Eibich, Peter and Fontanillas, Pierre and Gonzalez, Juan R. and Joshi, Peter K. and Karhunen, Ville and Kleinman, Aaron and Levin, Remy Z. and Lill, Christina M. and Meddens, Gerardus A. and Muntan\'{e}, Gerard and Sanchez-Roige, Sandra and Rooij, Frank J. van and Taskesen, Erdogan and Wu, Yang and Zhang, Futao and Auton, Adam and Boardman, Jason D. and Clark, David W. and Conlin, Andrew and Dolan, Conor C. and Fischbacher, Urs and Groenen, Patrick J. F. and Harris, Kathleen Mullan and Hasler, Gregor and Hofman, Albert and Ikram, Mohammad A. and Jain, Sonia and Karlsson, Robert and Kessler, Ronald C. and Kooyman, Maarten and MacKillop, James and M\"{a}nnikk\"{o}, Minna and Morcillo-Suarez, Carlos and McQueen, Matthew B. and Schmidt, Klaus M. and Smart, Melissa C. and Sutter, Matthias and Thurik, A. Roy and Uitterlinden, Andr\'{e} G. and White, Jon and Wit, Harriet de and Yang, Jian and Bertram, Lars and Boomsma, Dorret I. and Esko, T\~{o}nu and Fehr, Ernst and Hinds, David A. and Johannesson, Magnus and Kumari, Meena and Laibson, David and Magnusson, Patrik K. E. and Meyer, Michelle N. and Navarro, Arcadi and Palmer, Abraham A. and Pers, Tune H. and Posthuma, Danielle and Schunk, Daniel and Stein, Murray B. and Svento, Rauli and Tiemeier, Henning and Timmers, Paul R. H. J. and Turley, Patrick and Ursano, Robert J. and Wagner, Gert G. and Wilson, James F. and Gratten, Jacob and Lee, James J. and Cesarini, David and Benjamin, Daniel J. and Koellinger, Philipp D. and Beauchamp, Jonathan P.}, year = {2019}, pages = {245-257}, DOI = {10.1038/s41588-018-0309-3}, keywords = {GENDER-DIFFERENCES, GWAS, DETERMINANTS, PREFERENCES, PERSONALITY, LD}, journal = {Nature Genetics}, doi = {10.1038/s41588-018-0309-3}, volume = {51}, number = {2}, issn = {1061-4036}, title = {Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences}, keyword = {GENDER-DIFFERENCES, GWAS, DETERMINANTS, PREFERENCES, PERSONALITY, LD} }
@article{article, author = {Karlsson Linn\'{e}r, Richard and Biroli, Pietro and Kong, Edward and Meddens, S. Fleur W. and Wedow, Robbee and Fontana, Mark Alan and Lebreton, Ma\"{e}l and Tino, Stephen P. and Abdellaoui, Abdel and Hammerschlag, Anke R. and Nivard, Michel G. and Okbay, Aysu and Rietveld, Cornelius A. and Timshel, Pascal N. and Trzaskowski, Maciej and Vlaming, Ronald de and Z\"{u}nd, Christian L. and Bao, Yanchun and Buzdugan, Laura and Caplin, Ann H. and Chen, Chia-Yen and Eibich, Peter and Fontanillas, Pierre and Gonzalez, Juan R. and Joshi, Peter K. and Karhunen, Ville and Kleinman, Aaron and Levin, Remy Z. and Lill, Christina M. and Meddens, Gerardus A. and Muntan\'{e}, Gerard and Sanchez-Roige, Sandra and Rooij, Frank J. van and Taskesen, Erdogan and Wu, Yang and Zhang, Futao and Auton, Adam and Boardman, Jason D. and Clark, David W. and Conlin, Andrew and Dolan, Conor C. and Fischbacher, Urs and Groenen, Patrick J. F. and Harris, Kathleen Mullan and Hasler, Gregor and Hofman, Albert and Ikram, Mohammad A. and Jain, Sonia and Karlsson, Robert and Kessler, Ronald C. and Kooyman, Maarten and MacKillop, James and M\"{a}nnikk\"{o}, Minna and Morcillo-Suarez, Carlos and McQueen, Matthew B. and Schmidt, Klaus M. and Smart, Melissa C. and Sutter, Matthias and Thurik, A. Roy and Uitterlinden, Andr\'{e} G. and White, Jon and Wit, Harriet de and Yang, Jian and Bertram, Lars and Boomsma, Dorret I. and Esko, T\~{o}nu and Fehr, Ernst and Hinds, David A. and Johannesson, Magnus and Kumari, Meena and Laibson, David and Magnusson, Patrik K. E. and Meyer, Michelle N. and Navarro, Arcadi and Palmer, Abraham A. and Pers, Tune H. and Posthuma, Danielle and Schunk, Daniel and Stein, Murray B. and Svento, Rauli and Tiemeier, Henning and Timmers, Paul R. H. J. and Turley, Patrick and Ursano, Robert J. and Wagner, Gert G. and Wilson, James F. and Gratten, Jacob and Lee, James J. and Cesarini, David and Benjamin, Daniel J. and Koellinger, Philipp D. and Beauchamp, Jonathan P.}, year = {2019}, pages = {245-257}, DOI = {10.1038/s41588-018-0309-3}, keywords = {GENDER-DIFFERENCES, GWAS, DETERMINANTS, PREFERENCES, PERSONALITY, LD}, journal = {Nature Genetics}, doi = {10.1038/s41588-018-0309-3}, volume = {51}, number = {2}, issn = {1061-4036}, title = {Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences}, keyword = {GENDER-DIFFERENCES, GWAS, DETERMINANTS, PREFERENCES, PERSONALITY, LD} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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