Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1252364

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

Lee, James J.; 23andMe Research Team; Wedow, Robbee; Okbay, Aysu; Kong, Edward; Maghzian, Omeed; Zacher, Meghan; Nguyen-Viet, Tuan Anh; Bowers, Peter; Sidorenko, Julia et al.
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals // Nature Genetics, 50 (2018), 8; 1112-1121 doi:10.1038/s41588-018-0147-3 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1252364 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

Autori
Lee, James J. ; 23andMe Research Team ; Wedow, Robbee ; Okbay, Aysu ; Kong, Edward ; Maghzian, Omeed ; Zacher, Meghan ; Nguyen-Viet, Tuan Anh ; Bowers, Peter ; Sidorenko, Julia ; Karlsson Linnér, Richard ; Fontana, Mark Alan ; Kundu, Tushar ; Lee, Chanwook ; Li, Hui ; Li, Ruoxi ; Royer, Rebecca ; Timshel, Pascal N. ; Walters, Raymond K. ; Willoughby, Emily A. ; Yengo, Loïc ; Alver, Maris ; Bao, Yanchun ; Clark, David W. ; Day, Felix R. ; Furlotte, Nicholas A. ; Joshi, Peter K. ; Kemper, Kathryn E. ; Kleinman, Aaron ; Langenberg, Claudia ; Mägi, Reedik ; Trampush, Joey W. ; Verma, Shefali Setia ; Wu, Yang ; Lam, Max ; Zhao, Jing Hua ; Zheng, Zhili ; Boardman, Jason D. ; Campbell, Harry ; Freese, Jeremy ; Harris, Kathleen Mullan ; Hayward, Caroline ; Herd, Pamela ; Kumari, Meena ; Lencz, Todd ; Luan, Jian’an ; Malhotra, Anil K. ; Metspalu, Andres ; Milani, Lili ; Ong, Ken K. ; Perry, John R. B. ; Porteous, David J. ; Ritchie, Marylyn D. ; Smart, Melissa C. ; Smith, Blair H. ; Tung, Joyce Y. ; Wareham, Nicholas J. ; Wilson, James F. ; Beauchamp, Jonathan P. ; Conley, Dalton C. ; Esko, Tõnu ; Lehrer, Steven F. ; Magnusson, Patrik K. E. ; Oskarsson, Sven ; Pers, Tune H. ; Robinson, Matthew R. ; Thom, Kevin ; Watson, Chelsea ; Chabris, Christopher F. ; Meyer, Michelle N. ; Laibson, David I. ; Yang, Jian ; Johannesson, Magnus ; Koellinger, Philipp D. ; Turley, Patrick ; Visscher, Peter M. ; Benjamin, Daniel J. ; Cesarini, David ; COGENT (Cognitive Genomics Consortium) ; Social Science Genetic Association Consortium

Izvornik
Nature Genetics (1061-4036) 50 (2018), 8; 1112-1121

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Educational Status ; Female ; Genome-Wide Association Study ; Humans ; Male ; Middle Aged ; Multifactorial Inheritance ; Phenotype ; Polymorphism, Single Nucleotide

Sažetak
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1, 271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ivana Kolčić (autor)

Avatar Url Ozren Polašek (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Lee, James J.; 23andMe Research Team; Wedow, Robbee; Okbay, Aysu; Kong, Edward; Maghzian, Omeed; Zacher, Meghan; Nguyen-Viet, Tuan Anh; Bowers, Peter; Sidorenko, Julia et al.
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals // Nature Genetics, 50 (2018), 8; 1112-1121 doi:10.1038/s41588-018-0147-3 (međunarodna recenzija, članak, znanstveni)
Lee, J., 23andMe Research Team, Wedow, R., Okbay, A., Kong, E., Maghzian, O., Zacher, M., Nguyen-Viet, T., Bowers, P. & Sidorenko, J. (2018) Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50 (8), 1112-1121 doi:10.1038/s41588-018-0147-3.
@article{article, author = {Lee, James J. and Wedow, Robbee and Okbay, Aysu and Kong, Edward and Maghzian, Omeed and Zacher, Meghan and Nguyen-Viet, Tuan Anh and Bowers, Peter and Sidorenko, Julia and Karlsson Linn\'{e}r, Richard and Fontana, Mark Alan and Kundu, Tushar and Lee, Chanwook and Li, Hui and Li, Ruoxi and Royer, Rebecca and Timshel, Pascal N. and Walters, Raymond K. and Willoughby, Emily A. and Yengo, Lo\"{\i}c and Alver, Maris and Bao, Yanchun and Clark, David W. and Day, Felix R. and Furlotte, Nicholas A. and Joshi, Peter K. and Kemper, Kathryn E. and Kleinman, Aaron and Langenberg, Claudia and M\"{a}gi, Reedik and Trampush, Joey W. and Verma, Shefali Setia and Wu, Yang and Lam, Max and Zhao, Jing Hua and Zheng, Zhili and Boardman, Jason D. and Campbell, Harry and Freese, Jeremy and Harris, Kathleen Mullan and Hayward, Caroline and Herd, Pamela and Kumari, Meena and Lencz, Todd and Luan, Jian’an and Malhotra, Anil K. and Metspalu, Andres and Milani, Lili and Ong, Ken K. and Perry, John R. B. and Porteous, David J. and Ritchie, Marylyn D. and Smart, Melissa C. and Smith, Blair H. and Tung, Joyce Y. and Wareham, Nicholas J. and Wilson, James F. and Beauchamp, Jonathan P. and Conley, Dalton C. and Esko, T\~{o}nu and Lehrer, Steven F. and Magnusson, Patrik K. E. and Oskarsson, Sven and Pers, Tune H. and Robinson, Matthew R. and Thom, Kevin and Watson, Chelsea and Chabris, Christopher F. and Meyer, Michelle N. and Laibson, David I. and Yang, Jian and Johannesson, Magnus and Koellinger, Philipp D. and Turley, Patrick and Visscher, Peter M. and Benjamin, Daniel J. and Cesarini, David}, year = {2018}, pages = {1112-1121}, DOI = {10.1038/s41588-018-0147-3}, keywords = {Adult, Aged, Aged, 80 and over, Cohort Studies, Educational Status, Female, Genome-Wide Association Study, Humans, Male, Middle Aged, Multifactorial Inheritance, Phenotype, Polymorphism, Single Nucleotide}, journal = {Nature Genetics}, doi = {10.1038/s41588-018-0147-3}, volume = {50}, number = {8}, issn = {1061-4036}, title = {Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals}, keyword = {Adult, Aged, Aged, 80 and over, Cohort Studies, Educational Status, Female, Genome-Wide Association Study, Humans, Male, Middle Aged, Multifactorial Inheritance, Phenotype, Polymorphism, Single Nucleotide} }
@article{article, author = {Lee, James J. and Wedow, Robbee and Okbay, Aysu and Kong, Edward and Maghzian, Omeed and Zacher, Meghan and Nguyen-Viet, Tuan Anh and Bowers, Peter and Sidorenko, Julia and Karlsson Linn\'{e}r, Richard and Fontana, Mark Alan and Kundu, Tushar and Lee, Chanwook and Li, Hui and Li, Ruoxi and Royer, Rebecca and Timshel, Pascal N. and Walters, Raymond K. and Willoughby, Emily A. and Yengo, Lo\"{\i}c and Alver, Maris and Bao, Yanchun and Clark, David W. and Day, Felix R. and Furlotte, Nicholas A. and Joshi, Peter K. and Kemper, Kathryn E. and Kleinman, Aaron and Langenberg, Claudia and M\"{a}gi, Reedik and Trampush, Joey W. and Verma, Shefali Setia and Wu, Yang and Lam, Max and Zhao, Jing Hua and Zheng, Zhili and Boardman, Jason D. and Campbell, Harry and Freese, Jeremy and Harris, Kathleen Mullan and Hayward, Caroline and Herd, Pamela and Kumari, Meena and Lencz, Todd and Luan, Jian’an and Malhotra, Anil K. and Metspalu, Andres and Milani, Lili and Ong, Ken K. and Perry, John R. B. and Porteous, David J. and Ritchie, Marylyn D. and Smart, Melissa C. and Smith, Blair H. and Tung, Joyce Y. and Wareham, Nicholas J. and Wilson, James F. and Beauchamp, Jonathan P. and Conley, Dalton C. and Esko, T\~{o}nu and Lehrer, Steven F. and Magnusson, Patrik K. E. and Oskarsson, Sven and Pers, Tune H. and Robinson, Matthew R. and Thom, Kevin and Watson, Chelsea and Chabris, Christopher F. and Meyer, Michelle N. and Laibson, David I. and Yang, Jian and Johannesson, Magnus and Koellinger, Philipp D. and Turley, Patrick and Visscher, Peter M. and Benjamin, Daniel J. and Cesarini, David}, year = {2018}, pages = {1112-1121}, DOI = {10.1038/s41588-018-0147-3}, keywords = {Adult, Aged, Aged, 80 and over, Cohort Studies, Educational Status, Female, Genome-Wide Association Study, Humans, Male, Middle Aged, Multifactorial Inheritance, Phenotype, Polymorphism, Single Nucleotide}, journal = {Nature Genetics}, doi = {10.1038/s41588-018-0147-3}, volume = {50}, number = {8}, issn = {1061-4036}, title = {Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals}, keyword = {Adult, Aged, Aged, 80 and over, Cohort Studies, Educational Status, Female, Genome-Wide Association Study, Humans, Male, Middle Aged, Multifactorial Inheritance, Phenotype, Polymorphism, Single Nucleotide} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.