Naslov
Impact of lymph node ratio on survival and recurrence outcomes in oral squamous cell carcinoma
(Impact of lymph node ratio on survival and recurrence outcomes in oral squamous cell carcinoma)

Autori
Mamić, Matija ; Lucijanić, Marko ; Lorencin, Mia ; Suton, Petar ; Lukšić, Ivica

Izvornik
International journal of oral and maxillofacial surgery (0901-5027) 51 (2022), 10; 1257-1263

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
lymph node ratio ; lymphatic metastasis ; mouth neoplasms ; neoplasm staging ; survival analysis

Sažetak
Growing evidence supports the lymph node ratio (LNR) as a prognostic factor for survival in patients with oral squamous cell carcinoma (OSCC). However, there is a lack of data regarding its association with recurrence outcomes. Data on 163 patients with OSCC who underwent primary surgical treatment at a tertiary centre between January 2009 and December 2015 were collected retrospectively and analysed. Receiver operating characteristic curve analysis was performed to determine optimal cut-off values for the survival analyses. Survival endpoints were disease progression/relapse for disease-free time (DFT), freedom from loco-regional recurrence (FLR), and freedom from distant metastasis (FDM), and as death from any cause for overall survival (OS). Patients with a lower LNR were found to have significantly superior DFT (LNR < 14%, P < 0.001), FLR (LNR <14%, P < 0.001), FDM (LNR <16%, P = 0.004), and OS (LNR <7%, P = 0.004) in comparison to patients with a higher LNR. LNR is a good predictor of survival and recurrence outcomes in OSCC

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA