Naslov
CD25 ⁺ FOXP3 ⁺ and CD4 ⁺ CD25 ⁺ cells distribution in decidual departments of women with severe and mild pre‐eclampsia: Comparison with healthy pregnancies

Autori
Orlović Vlaho, Martina ; Tomić, Vajdana ; Vukojević, Katarina ; Vasilj, Anja ; Pejić, Renato ; Lesko, Josip ; Šoljić, Violeta

Izvornik
American Journal of Reproductive Immunology (1046-7408) 84 (2020), 3; E13281, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
decidua ; forkhead transcription factors ; pre-eclampsia ; pregnancy ; T-lymphocytes ; regulatory

Sažetak
Problem: The aim of this study was to quantify and compare the distribution of regulatory CD25(+)FOXP3(+)and activated CD4(+)CD25(+)T cells in decidua basalis and parietalis of severe and mild pre-eclampsia (PE) to normal healthy pregnancies. Method of study: Decidual tissue (decidua basalis and parietalis) of 13 women with mild PE, 15 women with severe PE, and 19 women with healthy term pregnancies were analyzed by immunohistochemistry and double immunofluorescence. Results: The total number of CD25(+)FOXP3(+)cells/mm(2)in decidua basalis was decreased in the severe and mild PE versus normal pregnancy group. The total number of CD4(+)CD25(+)cells/mm(2)in decidua basalis was decreased in the severe PE versus normal pregnancy group. The number of CD25(+)FOXP3(+)and CD4(+)CD25(+)cells in decidua parietalis was decreased in both PE groups. Conclusion: Our data suggest that immunological changes of PE reflect on decidua basalis and parietalis and emphasize the importance of characterizing T cells in both decidual departments.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA