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Pregled bibliografske jedinice broj: 1251286

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

(Lifelines Cohort Study) de las Fuentes, Lisa; Sung, Yun Ju; Noordam, Raymond; Winkler, Thomas; Feitosa, Mary F.; Schwander, Karen; Bentley, Amy R.; Brown, Michael R.; Guo, Xiuqing; Manning, Alisa et al.
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci // Molecular Psychiatry, 26 (2020), 6; 2111-2125 doi:10.1038/s41380-020-0719-3 (međunarodna recenzija, članak, znanstveni)

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Naslov
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Autori
De las Fuentes, Lisa ; Sung, Yun Ju ; Noordam, Raymond ; Winkler, Thomas ; Feitosa, Mary F. ; Schwander, Karen ; Bentley, Amy R. ; Brown, Michael R. ; Guo, Xiuqing ; Manning, Alisa ; Chasman, Daniel I. ; Aschard, Hugues ; Bartz, Traci M. ; Bielak, Lawrence F. ; Campbell, Archie ; Cheng, Ching-Yu ; Dorajoo, Rajkumar ; Hartwig, Fernando P. ; Horimoto, A. R. V. R. ; Li, Changwei ; Li-Gao, Ruifang ; Liu, Yongmei ; Marten, Jonathan ; Musani, Solomon K. ; Ntalla, Ioanna ; Rankinen, Tuomo ; Richard, Melissa ; Sim, Xueling ; Smith, Albert V. ; Tajuddin, Salman M. ; Tayo, Bamidele O. ; Vojinovic, Dina ; Warren, Helen R. ; Xuan, Deng ; Alver, Maris ; Boissel, Mathilde ; Chai, Jin-Fang ; Chen, Xu ; Christensen, Kaare ; Divers, Jasmin ; Evangelou, Evangelos ; Gao, Chuan ; Girotto, Giorgia ; Harris, Sarah E. ; He, Meian ; Hsu, Fang-Chi ; Kühnel, Brigitte ; Laguzzi, Federica ; Li, Xiaoyin ; Lyytikäinen, Leo-Pekka ; Nolte, Ilja M. ; Poveda, Alaitz ; Rauramaa, Rainer ; Riaz, Muhammad ; Rueedi, Rico ; Shu, Xiao-ou ; Snieder, Harold ; Sofer, Tamar ; Takeuchi, Fumihiko ; Verweij, Niek ; Ware, Erin B. ; Weiss, Stefan ; Yanek, Lisa R. ; Amin, Najaf ; Arking, Dan E. ; Arnett, Donna K. ; Bergmann, Sven ; Boerwinkle, Eric ; Brody, Jennifer A. ; Broeckel, Ulrich ; Brumat, Marco ; Burke, Gregory ; Cabrera, Claudia P. ; Canouil, Mickaël ; Chee, Miao Li ; Chen, Yii-Der Ida ; Cocca, Massimiliano ; Connell, John ; de Silva, H. Janaka ; de Vries, Paul S. ; Eiriksdottir, Gudny ; Faul, Jessica D. ; Fisher, Virginia ; Forrester, Terrence ; Fox, Ervin F. ; Friedlander, Yechiel ; Gao, He ; Gigante, Bruna ; Giulianini, Franco ; Gu, Chi Charles ; Gu, Dongfeng ; Harris, Tamara B. ; He, Jiang ; Heikkinen, Sami ; Heng, Chew-Kiat ; Hunt, Steven ; Ikram, M. Arfan ; Irvin, Marguerite R. ; Kähönen, Mika ; Kavousi, Maryam ; Khor, Chiea Chuen ; Kilpeläinen, Tuomas O. ; Koh, Woon-Puay ; Komulainen, Pirjo ; Kraja, Aldi T. ; Krieger, J. E. ; Langefeld, Carl D. ; Li, Yize ; Liang, Jingjing ; Liewald, David C. M. ; Liu, Ching-Ti ; Liu, Jianjun ; Lohman, Kurt K. ; Mägi, Reedik ; McKenzie, Colin A. ; Meitinger, Thomas ; Metspalu, Andres ; Milaneschi, Yuri ; Milani, Lili ; Mook- Kanamori, Dennis O. ; Nalls, Mike A. ; Nelson, Christopher P. ; Norris, Jill M. ; O’Connell, Jeff ; Ogunniyi, Adesola ; Padmanabhan, Sandosh ; Palmer, Nicholette D. ; Pedersen, Nancy L. ; Perls, Thomas ; Peters, Annette ; Petersmann, Astrid ; Peyser, Patricia A. ; Polasek, Ozren ; Porteous, David J. ; Raffel, Leslie J. ; Rice, Treva K. ; Rotter, Jerome I. ; Rudan, Igor ; Rueda-Ochoa, Oscar-Leonel ; Sabanayagam, Charumathi ; Salako, Babatunde L. ; Schreiner, Pamela J. ; Shikany, James M. ; Sidney, Stephen S. ; Sims, Mario ; Sitlani, Colleen M. ; Smith, Jennifer A. ; Starr, John M. ; Strauch, Konstantin ; Swertz, Morris A. ; Teumer, Alexander ; Tham, Yih Chung ; Uitterlinden, André G. ; Vaidya, Dhananjay ; van der Ende, M. Yldau ; Waldenberger, Melanie ; Wang, Lihua ; Wang, Ya-Xing ; Wei, Wen- Bin ; Weir, David R. ; Wen, Wanqing ; Yao, Jie ; Yu, Bing ; Yu, Caizheng ; Yuan, Jian-Min ; Zhao, Wei ; Zonderman, Alan B. ; Becker, Diane M. ; Bowden, Donald W. ; Deary, Ian J. ; Dörr, Marcus ; Esko, Tõnu ; Freedman, Barry I. ; Froguel, Philippe ; Gasparini, Paolo ; Gieger, Christian ; Jonas, Jost Bruno ; Kammerer, Candace M. ; Kato, Norihiro ; Lakka, Timo A. ; Leander, Karin ; Lehtimäki, Terho ; Magnusson, Patrik K. E. ; Marques-Vidal, Pedro ; Penninx, Brenda W. J. H. ; Samani, Nilesh J. ; van der Harst, Pim ; Wagenknecht, Lynne E. ; Wu, Tangchun ; Zheng, Wei ; Zhu, Xiaofeng ; Bouchard, Claude ; Cooper, Richard S. ; Correa, Adolfo ; Evans, Michele K. ; Gudnason, Vilmundur ; Hayward, Caroline ; Horta, Bernardo L. ; Kelly, Tanika N. ; Kritchevsky, Stephen B. ; Levy, Daniel ; Palmas, Walter R. ; Pereira, A. C. ; Province, Michael M. ; Psaty, Bruce M. ; Ridker, Paul M. ; Rotimi, Charles N. ; Tai, E. Shyong ; van Dam, Rob M. ; van Duijn, Cornelia M. ; Wong, Tien Yin ; Rice, Kenneth ; Gauderman, W. James ; Morrison, Alanna C. ; North, Kari E. ; Kardia, Sharon L. R. ; Caulfield, Mark J. ; Elliott, Paul ; Munroe, Patricia B. ; Franks, Paul W. ; Rao, Dabeeru C. ; Fornage, Myriam ; Lifelines Cohort Study

Kolaboracija
Lifelines Cohort Study

Izvornik
Molecular Psychiatry (1359-4184) 26 (2020), 6; 2111-2125

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CORONARY-HEART-DISEASE ; SOCIOECONOMIC-STATUS ; RISK-FACTORS ; CARDIOVASCULAR-DISEASE ; ESSENTIAL-HYPERTENSION ; C825T POLYMORPHISM ; SOCIAL-CLASS ; ASSOCIATION ; EXPRESSION ; VARIANTS

Sažetak
Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, Some College (yes/no) and Graduated College (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects. Analyses were performed for systolic BP, diastolic BP, mean arterial pressure, and pulse pressure. We pursued genome-wide interrogation in Stage 1 studies (N = 117 438) and follow-up on promising variants in Stage 2 studies (N = 293 787) in five ancestry groups. Through combined meta-analyses of Stages 1 and 2, we identified 84 known and 18 novel BP loci at genome-wide significance level (P < 5 x 10(-8)). Two novel loci were identified based on the 1DF test of interaction with educational attainment, while the remaining 16 loci were identified through the 2DF joint test of genetic and interaction effects. Ten novel loci were identified in individuals of African ancestry. Several novel loci show strong biological plausibility since they involve physiologic systems implicated in BP regulation. They include genes involved in the central nervous system- adrenal signaling axis (ZDHHC17, CADPS, PIK3C2G), vascular structure and function (GNB3, CDON), and renal function (HAS2 and HAS2-AS1, SLIT3). Collectively, these findings suggest a role of educational attainment or SES in further dissection of the genetic architecture of BP.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Avatar Url Igor Rudan (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

(Lifelines Cohort Study) de las Fuentes, Lisa; Sung, Yun Ju; Noordam, Raymond; Winkler, Thomas; Feitosa, Mary F.; Schwander, Karen; Bentley, Amy R.; Brown, Michael R.; Guo, Xiuqing; Manning, Alisa et al.
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci // Molecular Psychiatry, 26 (2020), 6; 2111-2125 doi:10.1038/s41380-020-0719-3 (međunarodna recenzija, članak, znanstveni)
(Lifelines Cohort Study) (Lifelines Cohort Study) de las Fuentes, L., Sung, Y., Noordam, R., Winkler, T., Feitosa, M., Schwander, K., Bentley, A., Brown, M., Guo, X. & Manning, A. (2020) Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. Molecular Psychiatry, 26 (6), 2111-2125 doi:10.1038/s41380-020-0719-3.
@article{article, author = {de las Fuentes, Lisa and Sung, Yun Ju and Noordam, Raymond and Winkler, Thomas and Feitosa, Mary F. and Schwander, Karen and Bentley, Amy R. and Brown, Michael R. and Guo, Xiuqing and Manning, Alisa and Chasman, Daniel I. and Aschard, Hugues and Bartz, Traci M. and Bielak, Lawrence F. and Campbell, Archie and Cheng, Ching-Yu and Dorajoo, Rajkumar and Hartwig, Fernando P. and Horimoto, A. R. V. R. and Li, Changwei and Li-Gao, Ruifang and Liu, Yongmei and Marten, Jonathan and Musani, Solomon K. and Ntalla, Ioanna and Rankinen, Tuomo and Richard, Melissa and Sim, Xueling and Smith, Albert V. and Tajuddin, Salman M. and Tayo, Bamidele O. and Vojinovic, Dina and Warren, Helen R. and Xuan, Deng and Alver, Maris and Boissel, Mathilde and Chai, Jin-Fang and Chen, Xu and Christensen, Kaare and Divers, Jasmin and Evangelou, Evangelos and Gao, Chuan and Girotto, Giorgia and Harris, Sarah E. and He, Meian and Hsu, Fang-Chi and K\"{u}hnel, Brigitte and Laguzzi, Federica and Li, Xiaoyin and Lyytik\"{a}inen, Leo-Pekka and Nolte, Ilja M. and Poveda, Alaitz and Rauramaa, Rainer and Riaz, Muhammad and Rueedi, Rico and Shu, Xiao-ou and Snieder, Harold and Sofer, Tamar and Takeuchi, Fumihiko and Verweij, Niek and Ware, Erin B. and Weiss, Stefan and Yanek, Lisa R. and Amin, Najaf and Arking, Dan E. and Arnett, Donna K. and Bergmann, Sven and Boerwinkle, Eric and Brody, Jennifer A. and Broeckel, Ulrich and Brumat, Marco and Burke, Gregory and Cabrera, Claudia P. and Canouil, Micka\"{e}l and Chee, Miao Li and Chen, Yii-Der Ida and Cocca, Massimiliano and Connell, John and de Silva, H. Janaka and de Vries, Paul S. and Eiriksdottir, Gudny and Faul, Jessica D. and Fisher, Virginia and Forrester, Terrence and Fox, Ervin F. and Friedlander, Yechiel and Gao, He and Gigante, Bruna and Giulianini, Franco and Gu, Chi Charles and Gu, Dongfeng and Harris, Tamara B. and He, Jiang and Heikkinen, Sami and Heng, Chew-Kiat and Hunt, Steven and Ikram, M. Arfan and Irvin, Marguerite R. and K\"{a}h\"{o}nen, Mika and Kavousi, Maryam and Khor, Chiea Chuen and Kilpel\"{a}inen, Tuomas O. and Koh, Woon-Puay and Komulainen, Pirjo and Kraja, Aldi T. and Krieger, J. E. and Langefeld, Carl D. and Li, Yize and Liang, Jingjing and Liewald, David C. M. and Liu, Ching-Ti and Liu, Jianjun and Lohman, Kurt K. and M\"{a}gi, Reedik and McKenzie, Colin A. and Meitinger, Thomas and Metspalu, Andres and Milaneschi, Yuri and Milani, Lili and Mook- Kanamori, Dennis O. and Nalls, Mike A. and Nelson, Christopher P. and Norris, Jill M. and O’Connell, Jeff and Ogunniyi, Adesola and Padmanabhan, Sandosh and Palmer, Nicholette D. and Pedersen, Nancy L. and Perls, Thomas and Peters, Annette and Petersmann, Astrid and Peyser, Patricia A. and Polasek, Ozren and Porteous, David J. and Raffel, Leslie J. and Rice, Treva K. and Rotter, Jerome I. and Rudan, Igor and Rueda-Ochoa, Oscar-Leonel and Sabanayagam, Charumathi and Salako, Babatunde L. and Schreiner, Pamela J. and Shikany, James M. and Sidney, Stephen S. and Sims, Mario and Sitlani, Colleen M. and Smith, Jennifer A. and Starr, John M. and Strauch, Konstantin and Swertz, Morris A. and Teumer, Alexander and Tham, Yih Chung and Uitterlinden, Andr\'{e} G. and Vaidya, Dhananjay and van der Ende, M. Yldau and Waldenberger, Melanie and Wang, Lihua and Wang, Ya-Xing and Wei, Wen- Bin and Weir, David R. and Wen, Wanqing and Yao, Jie and Yu, Bing and Yu, Caizheng and Yuan, Jian-Min and Zhao, Wei and Zonderman, Alan B. and Becker, Diane M. and Bowden, Donald W. and Deary, Ian J. and D\"{o}rr, Marcus and Esko, T\~{o}nu and Freedman, Barry I. and Froguel, Philippe and Gasparini, Paolo and Gieger, Christian and Jonas, Jost Bruno and Kammerer, Candace M. and Kato, Norihiro and Lakka, Timo A. and Leander, Karin and Lehtim\"{a}ki, Terho and Magnusson, Patrik K. E. and Marques-Vidal, Pedro and Penninx, Brenda W. J. H. and Samani, Nilesh J. and van der Harst, Pim and Wagenknecht, Lynne E. and Wu, Tangchun and Zheng, Wei and Zhu, Xiaofeng and Bouchard, Claude and Cooper, Richard S. and Correa, Adolfo and Evans, Michele K. and Gudnason, Vilmundur and Hayward, Caroline and Horta, Bernardo L. and Kelly, Tanika N. and Kritchevsky, Stephen B. and Levy, Daniel and Palmas, Walter R. and Pereira, A. C. and Province, Michael M. and Psaty, Bruce M. and Ridker, Paul M. and Rotimi, Charles N. and Tai, E. Shyong and van Dam, Rob M. and van Duijn, Cornelia M. and Wong, Tien Yin and Rice, Kenneth and Gauderman, W. James and Morrison, Alanna C. and North, Kari E. and Kardia, Sharon L. R. and Caulfield, Mark J. and Elliott, Paul and Munroe, Patricia B. and Franks, Paul W. and Rao, Dabeeru C. and Fornage, Myriam}, year = {2020}, pages = {2111-2125}, DOI = {10.1038/s41380-020-0719-3}, keywords = {CORONARY-HEART-DISEASE, SOCIOECONOMIC-STATUS, RISK-FACTORS, CARDIOVASCULAR-DISEASE, ESSENTIAL-HYPERTENSION, C825T POLYMORPHISM, SOCIAL-CLASS, ASSOCIATION, EXPRESSION, VARIANTS}, journal = {Molecular Psychiatry}, doi = {10.1038/s41380-020-0719-3}, volume = {26}, number = {6}, issn = {1359-4184}, title = {Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci}, keyword = {CORONARY-HEART-DISEASE, SOCIOECONOMIC-STATUS, RISK-FACTORS, CARDIOVASCULAR-DISEASE, ESSENTIAL-HYPERTENSION, C825T POLYMORPHISM, SOCIAL-CLASS, ASSOCIATION, EXPRESSION, VARIANTS} }
@article{article, author = {de las Fuentes, Lisa and Sung, Yun Ju and Noordam, Raymond and Winkler, Thomas and Feitosa, Mary F. and Schwander, Karen and Bentley, Amy R. and Brown, Michael R. and Guo, Xiuqing and Manning, Alisa and Chasman, Daniel I. and Aschard, Hugues and Bartz, Traci M. and Bielak, Lawrence F. and Campbell, Archie and Cheng, Ching-Yu and Dorajoo, Rajkumar and Hartwig, Fernando P. and Horimoto, A. R. V. R. and Li, Changwei and Li-Gao, Ruifang and Liu, Yongmei and Marten, Jonathan and Musani, Solomon K. and Ntalla, Ioanna and Rankinen, Tuomo and Richard, Melissa and Sim, Xueling and Smith, Albert V. and Tajuddin, Salman M. and Tayo, Bamidele O. and Vojinovic, Dina and Warren, Helen R. and Xuan, Deng and Alver, Maris and Boissel, Mathilde and Chai, Jin-Fang and Chen, Xu and Christensen, Kaare and Divers, Jasmin and Evangelou, Evangelos and Gao, Chuan and Girotto, Giorgia and Harris, Sarah E. and He, Meian and Hsu, Fang-Chi and K\"{u}hnel, Brigitte and Laguzzi, Federica and Li, Xiaoyin and Lyytik\"{a}inen, Leo-Pekka and Nolte, Ilja M. and Poveda, Alaitz and Rauramaa, Rainer and Riaz, Muhammad and Rueedi, Rico and Shu, Xiao-ou and Snieder, Harold and Sofer, Tamar and Takeuchi, Fumihiko and Verweij, Niek and Ware, Erin B. and Weiss, Stefan and Yanek, Lisa R. and Amin, Najaf and Arking, Dan E. and Arnett, Donna K. and Bergmann, Sven and Boerwinkle, Eric and Brody, Jennifer A. and Broeckel, Ulrich and Brumat, Marco and Burke, Gregory and Cabrera, Claudia P. and Canouil, Micka\"{e}l and Chee, Miao Li and Chen, Yii-Der Ida and Cocca, Massimiliano and Connell, John and de Silva, H. Janaka and de Vries, Paul S. and Eiriksdottir, Gudny and Faul, Jessica D. and Fisher, Virginia and Forrester, Terrence and Fox, Ervin F. and Friedlander, Yechiel and Gao, He and Gigante, Bruna and Giulianini, Franco and Gu, Chi Charles and Gu, Dongfeng and Harris, Tamara B. and He, Jiang and Heikkinen, Sami and Heng, Chew-Kiat and Hunt, Steven and Ikram, M. Arfan and Irvin, Marguerite R. and K\"{a}h\"{o}nen, Mika and Kavousi, Maryam and Khor, Chiea Chuen and Kilpel\"{a}inen, Tuomas O. and Koh, Woon-Puay and Komulainen, Pirjo and Kraja, Aldi T. and Krieger, J. E. and Langefeld, Carl D. and Li, Yize and Liang, Jingjing and Liewald, David C. M. and Liu, Ching-Ti and Liu, Jianjun and Lohman, Kurt K. and M\"{a}gi, Reedik and McKenzie, Colin A. and Meitinger, Thomas and Metspalu, Andres and Milaneschi, Yuri and Milani, Lili and Mook- Kanamori, Dennis O. and Nalls, Mike A. and Nelson, Christopher P. and Norris, Jill M. and O’Connell, Jeff and Ogunniyi, Adesola and Padmanabhan, Sandosh and Palmer, Nicholette D. and Pedersen, Nancy L. and Perls, Thomas and Peters, Annette and Petersmann, Astrid and Peyser, Patricia A. and Polasek, Ozren and Porteous, David J. and Raffel, Leslie J. and Rice, Treva K. and Rotter, Jerome I. and Rudan, Igor and Rueda-Ochoa, Oscar-Leonel and Sabanayagam, Charumathi and Salako, Babatunde L. and Schreiner, Pamela J. and Shikany, James M. and Sidney, Stephen S. and Sims, Mario and Sitlani, Colleen M. and Smith, Jennifer A. and Starr, John M. and Strauch, Konstantin and Swertz, Morris A. and Teumer, Alexander and Tham, Yih Chung and Uitterlinden, Andr\'{e} G. and Vaidya, Dhananjay and van der Ende, M. Yldau and Waldenberger, Melanie and Wang, Lihua and Wang, Ya-Xing and Wei, Wen- Bin and Weir, David R. and Wen, Wanqing and Yao, Jie and Yu, Bing and Yu, Caizheng and Yuan, Jian-Min and Zhao, Wei and Zonderman, Alan B. and Becker, Diane M. and Bowden, Donald W. and Deary, Ian J. and D\"{o}rr, Marcus and Esko, T\~{o}nu and Freedman, Barry I. and Froguel, Philippe and Gasparini, Paolo and Gieger, Christian and Jonas, Jost Bruno and Kammerer, Candace M. and Kato, Norihiro and Lakka, Timo A. and Leander, Karin and Lehtim\"{a}ki, Terho and Magnusson, Patrik K. E. and Marques-Vidal, Pedro and Penninx, Brenda W. J. H. and Samani, Nilesh J. and van der Harst, Pim and Wagenknecht, Lynne E. and Wu, Tangchun and Zheng, Wei and Zhu, Xiaofeng and Bouchard, Claude and Cooper, Richard S. and Correa, Adolfo and Evans, Michele K. and Gudnason, Vilmundur and Hayward, Caroline and Horta, Bernardo L. and Kelly, Tanika N. and Kritchevsky, Stephen B. and Levy, Daniel and Palmas, Walter R. and Pereira, A. C. and Province, Michael M. and Psaty, Bruce M. and Ridker, Paul M. and Rotimi, Charles N. and Tai, E. Shyong and van Dam, Rob M. and van Duijn, Cornelia M. and Wong, Tien Yin and Rice, Kenneth and Gauderman, W. James and Morrison, Alanna C. and North, Kari E. and Kardia, Sharon L. R. and Caulfield, Mark J. and Elliott, Paul and Munroe, Patricia B. and Franks, Paul W. and Rao, Dabeeru C. and Fornage, Myriam}, year = {2020}, pages = {2111-2125}, DOI = {10.1038/s41380-020-0719-3}, keywords = {CORONARY-HEART-DISEASE, SOCIOECONOMIC-STATUS, RISK-FACTORS, CARDIOVASCULAR-DISEASE, ESSENTIAL-HYPERTENSION, C825T POLYMORPHISM, SOCIAL-CLASS, ASSOCIATION, EXPRESSION, VARIANTS}, journal = {Molecular Psychiatry}, doi = {10.1038/s41380-020-0719-3}, volume = {26}, number = {6}, issn = {1359-4184}, title = {Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci}, keyword = {CORONARY-HEART-DISEASE, SOCIOECONOMIC-STATUS, RISK-FACTORS, CARDIOVASCULAR-DISEASE, ESSENTIAL-HYPERTENSION, C825T POLYMORPHISM, SOCIAL-CLASS, ASSOCIATION, EXPRESSION, VARIANTS} }

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