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Pregled bibliografske jedinice broj: 1251209

Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes

Corre, Tanguy; Arjona, Francisco J.; Hayward, Caroline; Youhanna, Sonia; de Baaij, Jeroen H.F.; Belge, Hendrica; Nägele, Nadine; Debaix, Huguette; Blanchard, Maxime G.; Traglia, Michela et al.
Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes // Journal of the American Society of Nephrology, 29 (2017), 1; 335-348 doi:10.1681/asn.2017030267 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1251209 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes

Autori
Corre, Tanguy ; Arjona, Francisco J. ; Hayward, Caroline ; Youhanna, Sonia ; de Baaij, Jeroen H.F. ; Belge, Hendrica ; Nägele, Nadine ; Debaix, Huguette ; Blanchard, Maxime G. ; Traglia, Michela ; Harris, Sarah E. ; Ulivi, Sheila ; Rueedi, Rico ; Lamparter, David ; Macé, Aurélien ; Sala, Cinzia ; Lenarduzzi, Stefania ; Ponte, Belen ; Pruijm, Menno ; Ackermann, Daniel ; Ehret, Georg ; Baptista, Daniela ; Polasek, Ozren ; Rudan, Igor ; Hurd, Toby W. ; Hastie, Nicholas D. ; Vitart, Veronique ; Waeber, Geràrd ; Kutalik, Zoltán ; Bergmann, Sven ; Vargas-Poussou, Rosa ; Konrad, Martin ; Gasparini, Paolo ; Deary, Ian J. ; Starr, John M. ; Toniolo, Daniela ; Vollenweider, Peter ; Hoenderop, Joost G.J. ; Bindels, René J.M. ; Bochud, Murielle ; Devuyst, Olivier

Izvornik
Journal of the American Society of Nephrology (1046-6673) 29 (2017), 1; 335-348

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DOUBLE-BLIND ; SECONDARY HYPOCALCEMIA ; NONDIABETIC SUBJECTS ; INSULIN SENSITIVITY ; CONTROLLED-TRIALS ; RANDOMIZED-TRIAL ; GENETIC-LOCI ; ZEBRAFISH ; SUPPLEMENTATION ; HYPOMAGNESEMIA

Sažetak
Magnesium (Mg2+) homeostasis is critical for metabolism. However, the genetic determinants of the renal handling of Mg2+, which is crucial for Mg2+ homeostasis, and the potential influence on metabolic traits in the general population are unknown. We obtained plasma and urine parameters from 9099 individuals from seven cohorts, and conducted a genome-wide meta-analysis of Mg2+ homeostasis. We identified two loci associated with urinary magnesium (uMg), rs3824347 (P=4.4x10(-13)) near TRPM6, which encodes an epithelial Mg2+ channel, and rs35929 (P=2.1x10(-11)), a variant of ARL15, which encodes a GTP-binding protein. Together, these loci account for 2.3% of the variation in 24-hour uMg excretion. In human kidney cells, ARL15 regulated TRPM6-mediated currents. In zebrafish, dietary Mg2+ regulated the expression of the highly conserved ARL15 ortholog arl15b, and arl15b knockdown resulted in renal Mg2+ wasting and metabolic disturbances. Finally, ARL15 rs35929 modified the association of uMg with fasting insulin and fat mass in a general population. In conclusion, this combined observational and experimental approach uncovered a gene-environment interaction linking Mg2+ deficiency to insulin resistance and obesity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Avatar Url Igor Rudan (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Corre, Tanguy; Arjona, Francisco J.; Hayward, Caroline; Youhanna, Sonia; de Baaij, Jeroen H.F.; Belge, Hendrica; Nägele, Nadine; Debaix, Huguette; Blanchard, Maxime G.; Traglia, Michela et al.
Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes // Journal of the American Society of Nephrology, 29 (2017), 1; 335-348 doi:10.1681/asn.2017030267 (međunarodna recenzija, članak, znanstveni)
Corre, T., Arjona, F., Hayward, C., Youhanna, S., de Baaij, J., Belge, H., Nägele, N., Debaix, H., Blanchard, M. & Traglia, M. (2017) Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes. Journal of the American Society of Nephrology, 29 (1), 335-348 doi:10.1681/asn.2017030267.
@article{article, author = {Corre, Tanguy and Arjona, Francisco J. and Hayward, Caroline and Youhanna, Sonia and de Baaij, Jeroen H.F. and Belge, Hendrica and N\"{a}gele, Nadine and Debaix, Huguette and Blanchard, Maxime G. and Traglia, Michela and Harris, Sarah E. and Ulivi, Sheila and Rueedi, Rico and Lamparter, David and Mac\'{e}, Aur\'{e}lien and Sala, Cinzia and Lenarduzzi, Stefania and Ponte, Belen and Pruijm, Menno and Ackermann, Daniel and Ehret, Georg and Baptista, Daniela and Polasek, Ozren and Rudan, Igor and Hurd, Toby W. and Hastie, Nicholas D. and Vitart, Veronique and Waeber, Ger\`{a}rd and Kutalik, Zolt\'{a}n and Bergmann, Sven and Vargas-Poussou, Rosa and Konrad, Martin and Gasparini, Paolo and Deary, Ian J. and Starr, John M. and Toniolo, Daniela and Vollenweider, Peter and Hoenderop, Joost G.J. and Bindels, Ren\'{e} J.M. and Bochud, Murielle and Devuyst, Olivier}, year = {2017}, pages = {335-348}, DOI = {10.1681/asn.2017030267}, keywords = {DOUBLE-BLIND, SECONDARY HYPOCALCEMIA, NONDIABETIC SUBJECTS, INSULIN SENSITIVITY, CONTROLLED-TRIALS, RANDOMIZED-TRIAL, GENETIC-LOCI, ZEBRAFISH, SUPPLEMENTATION, HYPOMAGNESEMIA}, journal = {Journal of the American Society of Nephrology}, doi = {10.1681/asn.2017030267}, volume = {29}, number = {1}, issn = {1046-6673}, title = {Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes}, keyword = {DOUBLE-BLIND, SECONDARY HYPOCALCEMIA, NONDIABETIC SUBJECTS, INSULIN SENSITIVITY, CONTROLLED-TRIALS, RANDOMIZED-TRIAL, GENETIC-LOCI, ZEBRAFISH, SUPPLEMENTATION, HYPOMAGNESEMIA} }
@article{article, author = {Corre, Tanguy and Arjona, Francisco J. and Hayward, Caroline and Youhanna, Sonia and de Baaij, Jeroen H.F. and Belge, Hendrica and N\"{a}gele, Nadine and Debaix, Huguette and Blanchard, Maxime G. and Traglia, Michela and Harris, Sarah E. and Ulivi, Sheila and Rueedi, Rico and Lamparter, David and Mac\'{e}, Aur\'{e}lien and Sala, Cinzia and Lenarduzzi, Stefania and Ponte, Belen and Pruijm, Menno and Ackermann, Daniel and Ehret, Georg and Baptista, Daniela and Polasek, Ozren and Rudan, Igor and Hurd, Toby W. and Hastie, Nicholas D. and Vitart, Veronique and Waeber, Ger\`{a}rd and Kutalik, Zolt\'{a}n and Bergmann, Sven and Vargas-Poussou, Rosa and Konrad, Martin and Gasparini, Paolo and Deary, Ian J. and Starr, John M. and Toniolo, Daniela and Vollenweider, Peter and Hoenderop, Joost G.J. and Bindels, Ren\'{e} J.M. and Bochud, Murielle and Devuyst, Olivier}, year = {2017}, pages = {335-348}, DOI = {10.1681/asn.2017030267}, keywords = {DOUBLE-BLIND, SECONDARY HYPOCALCEMIA, NONDIABETIC SUBJECTS, INSULIN SENSITIVITY, CONTROLLED-TRIALS, RANDOMIZED-TRIAL, GENETIC-LOCI, ZEBRAFISH, SUPPLEMENTATION, HYPOMAGNESEMIA}, journal = {Journal of the American Society of Nephrology}, doi = {10.1681/asn.2017030267}, volume = {29}, number = {1}, issn = {1046-6673}, title = {Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes}, keyword = {DOUBLE-BLIND, SECONDARY HYPOCALCEMIA, NONDIABETIC SUBJECTS, INSULIN SENSITIVITY, CONTROLLED-TRIALS, RANDOMIZED-TRIAL, GENETIC-LOCI, ZEBRAFISH, SUPPLEMENTATION, HYPOMAGNESEMIA} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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