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Pregled bibliografske jedinice broj: 1251196

Tubulin Binding and Polymerization Promoting Properties of Tubulin Polymerization Promoting Proteins Are Evolutionarily Conserved

Oláh, Judit; Szénási, Tibor; Szabó, Adél; Kovács, Kinga; Lőw, Péter; Štifanić, Mauro; Orosz, Ferenc
Tubulin Binding and Polymerization Promoting Properties of Tubulin Polymerization Promoting Proteins Are Evolutionarily Conserved // Biochemistry (Easton), 56 (2017), 7; 1017-1024 doi:10.1021/acs.biochem.6b00902 (međunarodna recenzija, članak, znanstveni)

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Naslov
Tubulin Binding and Polymerization Promoting Properties of Tubulin Polymerization Promoting Proteins Are Evolutionarily Conserved

Autori
Oláh, Judit ; Szénási, Tibor ; Szabó, Adél ; Kovács, Kinga ; Lőw, Péter ; Štifanić, Mauro ; Orosz, Ferenc

Izvornik
Biochemistry (Easton) (0006-2960) 56 (2017), 7; 1017-1024

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
INTRINSICALLY UNSTRUCTURED PROTEINS ; CIRCULAR-DICHROISM ; SECONDARY STRUCTURE ; RAT-BRAIN ; TPPP/P25 ; FAMILY ; PREDICTION ; DYNAMICS ; P25 ; OLIGODENDROCYTES

Sažetak
Tubulin polymerization promoting proteins (TPPPs) constitute a eukaryotic protein family. There are three TPPP paralogs in the human genome, denoted as TPPP1–TPPP3. TPPP1 and TPPP3 are intrinsically unstructured proteins (IUPs) that bind and polymerize tubulin and stabilize microtubules, but TPPP2 does not. Vertebrate TPPPs originated from the ancient invertebrate TPPP by two-round whole- genome duplication ; thus, whether the tubulin/microtubule binding function of TPPP1 and TPPP3 is a newly acquired property or was present in the invertebrate orthologs (generally one TPPP per species) has been an open question. To answer this question, we investigated a TPPP from a simple and early branching animal, the sponge Suberites domuncula. Bioinformatics, biochemical, immunochemical, spectroscopic, and electron microscopic data showed that the properties of the sponge protein correspond to those of TPPP1 ; namely, it is an IUP that strongly binds tubulin and induces its polymerization, proving that these features of animal TPPPs have been evolutionarily conserved.

Izvorni jezik
Engleski



POVEZANOST RADA

Ustanove:
Sveučilište Jurja Dobrile u Puli

Profili:

Avatar Url Mauro Štifanić (autor)

Poveznice na cjeloviti tekst rada:

doi www.webofscience.com

Citiraj ovu publikaciju:

Oláh, Judit; Szénási, Tibor; Szabó, Adél; Kovács, Kinga; Lőw, Péter; Štifanić, Mauro; Orosz, Ferenc
Tubulin Binding and Polymerization Promoting Properties of Tubulin Polymerization Promoting Proteins Are Evolutionarily Conserved // Biochemistry (Easton), 56 (2017), 7; 1017-1024 doi:10.1021/acs.biochem.6b00902 (međunarodna recenzija, članak, znanstveni)
Oláh, J., Szénási, T., Szabó, A., Kovács, K., Lőw, P., Štifanić, M. & Orosz, F. (2017) Tubulin Binding and Polymerization Promoting Properties of Tubulin Polymerization Promoting Proteins Are Evolutionarily Conserved. Biochemistry (Easton), 56 (7), 1017-1024 doi:10.1021/acs.biochem.6b00902.
@article{article, author = {Ola\'h, Judit and Sze\'na\'si, Tibor and Szabo\', Ade\'l and Kova\'cs, Kinga and Lo\Hw, Pe\'ter and S\vtifanic\', Mauro and Orosz, Ferenc}, year = {2017}, pages = {1017-1024}, DOI = {10.1021/acs.biochem.6b00902}, keywords = {INTRINSICALLY UNSTRUCTURED PROTEINS, CIRCULAR-DICHROISM, SECONDARY STRUCTURE, RAT-BRAIN, TPPP/P25, FAMILY, PREDICTION, DYNAMICS, P25, OLIGODENDROCYTES}, journal = {Biochemistry (Easton)}, doi = {10.1021/acs.biochem.6b00902}, volume = {56}, number = {7}, issn = {0006-2960}, title = {Tubulin Binding and Polymerization Promoting Properties of Tubulin Polymerization Promoting Proteins Are Evolutionarily Conserved}, keyword = {INTRINSICALLY UNSTRUCTURED PROTEINS, CIRCULAR-DICHROISM, SECONDARY STRUCTURE, RAT-BRAIN, TPPP/P25, FAMILY, PREDICTION, DYNAMICS, P25, OLIGODENDROCYTES} }
@article{article, author = {Ola\'h, Judit and Sze\'na\'si, Tibor and Szabo\', Ade\'l and Kova\'cs, Kinga and Lo\Hw, Pe\'ter and S\vtifanic\', Mauro and Orosz, Ferenc}, year = {2017}, pages = {1017-1024}, DOI = {10.1021/acs.biochem.6b00902}, keywords = {INTRINSICALLY UNSTRUCTURED PROTEINS, CIRCULAR-DICHROISM, SECONDARY STRUCTURE, RAT-BRAIN, TPPP/P25, FAMILY, PREDICTION, DYNAMICS, P25, OLIGODENDROCYTES}, journal = {Biochemistry (Easton)}, doi = {10.1021/acs.biochem.6b00902}, volume = {56}, number = {7}, issn = {0006-2960}, title = {Tubulin Binding and Polymerization Promoting Properties of Tubulin Polymerization Promoting Proteins Are Evolutionarily Conserved}, keyword = {INTRINSICALLY UNSTRUCTURED PROTEINS, CIRCULAR-DICHROISM, SECONDARY STRUCTURE, RAT-BRAIN, TPPP/P25, FAMILY, PREDICTION, DYNAMICS, P25, OLIGODENDROCYTES} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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