Naslov
Five-year Estimated Glomerular Filtration Rate in Patients With Hypoparathyroidism Treated With and Without rhPTH(1–84)

Autori
Chen, Kristina S ; Gosmanova, Elvira O ; Curhan, Gary C ; Ketteler, Markus ; Rubin, Mishaela ; Swallow, Elyse ; Zhao, Jing ; Wang, Jessie ; Sherry, Nicole ; Krasner, Alan ; Bilezikian, John P

Izvornik
The Journal of Clinical Endocrinology & ; Metabolism (0021-972X) 105 (2020), 10; E3557-e3565

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chronic hypoparathyroidism ; kidney function ; recombinant human parathyroid hormone (1-84) ; retrospective study

Sažetak
Context: Chronic hypoparathyroidism (HypoPT) is conventionally managed with oral calcium and active vitamin D. Recombinant human parathyroid hormone (1-84) (rhPTH[1-84]) is a therapy targeting the pathophysiology of HypoPT by replacing parathyroid hormone. Objective: To compare changes in the estimated glomerular filtration rate (eGFR) in patients with chronic HypoPT receiving or not receiving rhPTH(1-84) during a 5-year period. Design/Setting: A retrospective analysis of patients with chronic HypoPT treated with or without rhPTH(1-84). Patients: Sixty-nine patients with chronic HypoPT from 4 open-label, long-term trials (NCT00732615, NCT01268098, NCT01297309, and NCT02910466) composed the rhPTH(1-84) cohort and 53 patients with chronic HypoPT not receiving rhPTH(1-84) from the Geisinger Healthcare Database (01/2004- 06/2016) composed the historical control cohort. Interventions: The rhPTH(1-84) cohort (N = 69) received rhPTH(1-84) therapy ; the historical control cohort (N = 53) did not receive rhPTH(1- 84). Main Outcome Measures: Changes in eGFR from baseline during a 5-year follow-up were examined in multivariate regression analyses. Results: At baseline, demographic characteristics and eGFR were similar between cohorts, though the proportions with diabetes and cardiac disorders were lower in the rhPTH(1-84) cohort. At the end of follow-up, mean eGFR increased by 2.8 mL/min/1.73 m(2) in the rhPTH(1-84) cohort, while mean eGFR fell by 8.0 mL/min/1.73 m(2) in the control cohort. In the adjusted model, the difference in the annual eGFR change between the rhPTH(1-84) cohort and the control cohort was 1.7 mL/min/1.73 m(2) per year (P = 0.009). Conclusions: Estimated glomerular filtration rate was preserved for over 5 years among patients with chronic HypoPT receiving rhPTH(1-84) treatment, contrasting with an eGFR decline among those not receiving rhPTH(1-84).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA