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Pregled bibliografske jedinice broj: 1251162

Genetic Background of a Recurrent Unusual Combined Form of Retinal Vein Occlusion: A Case Report


Bucan, Kajo; Plestina Borjan, Ivna; Bucan, Ivona; Paradzik Simunovic, Martina; Borjan, Ivan
Genetic Background of a Recurrent Unusual Combined Form of Retinal Vein Occlusion: A Case Report // Case Reports in Ophthalmology, 9 (2018), 1; 248-253 doi:10.1159/000488234 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1251162 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genetic Background of a Recurrent Unusual Combined Form of Retinal Vein Occlusion: A Case Report

Autori
Bucan, Kajo ; Plestina Borjan, Ivna ; Bucan, Ivona ; Paradzik Simunovic, Martina ; Borjan, Ivan

Izvornik
Case Reports in Ophthalmology (1663-2699) 9 (2018), 1; 248-253

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Plasminogen activator inhibitor-1 ; PAI-1 4G/5G polymorphism ; Retinal vein occlusion ; Thrombophilia

Sažetak
The authors report a rare case of nonischemic branch retinal vein occlusion and nonischemic hemiretinal vein occlusion in a patient with impaired fibrinolysis. A 61-year-old woman presented to the Department of Ophthalmology, Clinical Hospital Center Split, Croatia, with acute blurring of vision in the right eye (RE) due to branch retinal vein occlusion. Ophthalmologic evaluation revealed a best corrected visual acuity (BCVA) of 0.02 in the RE and of 1.0 in the left eye. Ophthalmoscopy and fluorescein angiography of the RE demonstrated signs of nonischemic branch retinal vein occlusion. She was otherwise healthy and had no other ocular and systemic diseases. She was treated with 3 consecutive intravitreal applications of antivascular endothelial growth factor (anti-VEGF ; bevacizumab) due to cystoid macular edema with full resolution of the intraretinal fluid and improvement of the BCVA to 0.9. After 8 months, she presented again with acute blurring of vision in the same (right) eye with a BCVA of 0.5. Ophthalmoscopy and fluorescein angiography of the RE indicated nonischemic hemiretinal vein occlusion. She was treated with a single intravitreal application of anti-VEGF (ranibizumab) due to macular edema. Full resolution of the intraretinal fluid and improvement of the BCVA to 0.9 were achieved. A laboratory workup was performed to rule out all known causes of retinal venous occlusive disease, which showed negative results. A molecular analysis showed the gen of thrombophilia - plasminogen activator inhibitor (PAI)-1 4G/5G polymorphism genotype - as the only risk factor for retinal venous occlusive disease in our patient. (C) 2018 The Author(s) Published by S. Karger AG, Basel

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
KBC Split,
Medicinski fakultet, Split

Profili:

Avatar Url Ivna Pleština-Borjan (autor)

Avatar Url Kajo Bućan (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Bucan, Kajo; Plestina Borjan, Ivna; Bucan, Ivona; Paradzik Simunovic, Martina; Borjan, Ivan
Genetic Background of a Recurrent Unusual Combined Form of Retinal Vein Occlusion: A Case Report // Case Reports in Ophthalmology, 9 (2018), 1; 248-253 doi:10.1159/000488234 (međunarodna recenzija, članak, znanstveni)
Bucan, K., Plestina Borjan, I., Bucan, I., Paradzik Simunovic, M. & Borjan, I. (2018) Genetic Background of a Recurrent Unusual Combined Form of Retinal Vein Occlusion: A Case Report. Case Reports in Ophthalmology, 9 (1), 248-253 doi:10.1159/000488234.
@article{article, author = {Bucan, Kajo and Plestina Borjan, Ivna and Bucan, Ivona and Paradzik Simunovic, Martina and Borjan, Ivan}, year = {2018}, pages = {248-253}, DOI = {10.1159/000488234}, keywords = {Plasminogen activator inhibitor-1, PAI-1 4G/5G polymorphism, Retinal vein occlusion, Thrombophilia}, journal = {Case Reports in Ophthalmology}, doi = {10.1159/000488234}, volume = {9}, number = {1}, issn = {1663-2699}, title = {Genetic Background of a Recurrent Unusual Combined Form of Retinal Vein Occlusion: A Case Report}, keyword = {Plasminogen activator inhibitor-1, PAI-1 4G/5G polymorphism, Retinal vein occlusion, Thrombophilia} }
@article{article, author = {Bucan, Kajo and Plestina Borjan, Ivna and Bucan, Ivona and Paradzik Simunovic, Martina and Borjan, Ivan}, year = {2018}, pages = {248-253}, DOI = {10.1159/000488234}, keywords = {Plasminogen activator inhibitor-1, PAI-1 4G/5G polymorphism, Retinal vein occlusion, Thrombophilia}, journal = {Case Reports in Ophthalmology}, doi = {10.1159/000488234}, volume = {9}, number = {1}, issn = {1663-2699}, title = {Genetic Background of a Recurrent Unusual Combined Form of Retinal Vein Occlusion: A Case Report}, keyword = {Plasminogen activator inhibitor-1, PAI-1 4G/5G polymorphism, Retinal vein occlusion, Thrombophilia} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Emerging Sources Citation Index (ESCI)
  • Scopus


Citati:





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