Naslov
Relapse patterns in early‐PET negative, limited‐ stage Hodgkin lymphoma (HL) after ABVD with or without radiotherapy–a joint analysis of EORTC/LYSA/FIL H10 and NCRI RAPID trials

Autori
Fiaccadori, Valeria ; Neven, Anouk ; Fortpied, Catherine ; Aurer, Igor ; Andre, Marc ; Federico, Massimo ; Counsell, Nicholas ; Phillips, Elizabeth H. ; Clifton‐Hadley, Laura ; Barrington, Sally F. ; Illidge, Timothy ; Radford, John ; Raemaekers, John M. M.

Kolaboracija
EORTC Lymphoma Group

Izvornik
British Journal of Haematology (0007-1048) 200 (2022); 18594, 9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chemotherapy, early PET, Hodgkin lymphoma, radiotherapy, relapse

Sažetak
In the H10 and RAPID randomised trials, chemotherapy+radiotherapy (combined modalities treatment, CMT) was compared with chemotherapy (C) in limited-stage Hodgkin lymphoma (HL), with negative early positron emission tomography (ePETneg). We analysed patterns of relapses in the H10 trial, validated findings in the RAPID trial and performed a combined analysis stratified by trial. The impact of radiotherapy (RT) on risk of relapse was studied using adjusted Cox models, with time-varying effects. In H10, 1, 059 ePETneg patients were included (465 European Organisation for Research and Treatment of Cancer (EORTC) favourable [F], 594 unfavourable [U]). Among the F patients, 2/227 (1%) relapsed after CMT, 30/238 (13%) after C: of these relapses, 21/30 (70%) occurred in less than 2 years and 25/30 (83%) affected originally involved areas. Among the U group, 16/292 (5%) relapsed after CMT: 8/16 (50%) in less than 2 years, 11/16 (69%) in originally involved areas. After C 30/302 (10%) relapsed: 27/30 (90%) in less than 2 years, and 26/30 (87%) in originally involved areas. Similar results were observed in 419 ePETneg RAPID patients (241 F, 128 U, 50 unclassified): among F patients, 6/118 (5%) relapsed after CMT ; 13/123 (11%) after C: 11/13 (85%) in less than 2 years and 11/13 (85%) affecting originally involved areas. In U patients, 3/65 (5%) relapsed after CMT and 5/63 (8%) after C. In both trials, omitting RT in ePETneg HL resulted in more early relapses,

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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