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Pregled bibliografske jedinice broj: 1251025

Association of low-frequency and rare coding variants with information processing speed

Bressler, Jan; Davies, Gail; Smith, Albert V.; Saba, Yasaman; Bis, Joshua C.; Jian, Xueqiu; Hayward, Caroline; Yanek, Lisa; Smith, Jennifer A.; Mirza, Saira S. et al.
Association of low-frequency and rare coding variants with information processing speed // Translational Psychiatry, 11 (2021), 1; 613, 10 doi:10.1038/s41398-021-01736-6 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1251025 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Association of low-frequency and rare coding variants with information processing speed

Autori
Bressler, Jan ; Davies, Gail ; Smith, Albert V. ; Saba, Yasaman ; Bis, Joshua C. ; Jian, Xueqiu ; Hayward, Caroline ; Yanek, Lisa ; Smith, Jennifer A. ; Mirza, Saira S. ; Wang, Ruiqi ; Adams, Hieab H. H. ; Becker, Diane ; Boerwinkle, Eric ; Campbell, Archie ; Cox, Simon R. ; Eiriksdottir, Gudny ; Fawns-Ritchie, Chloe ; Gottesman, Rebecca F. ; Grove, Megan L. ; Guo, Xiuqing ; Hofer, Edith ; Kardia, Sharon L. R. ; Knol, Maria J. ; Koini, Marisa ; Lopez, Oscar L. ; Marioni, Riccardo E. ; Nyquist, Paul ; Pattie, Alison ; Polasek, Ozren ; Porteous, David J. ; Rudan, Igor ; Satizabal, Claudia L. ; Schmidt, Helena ; Schmidt, Reinhold ; Sidney, Stephen ; Simino, Jeannette ; Smith, Blair H. ; Turner, Stephen T. ; van der Lee, Sven J. ; Ware, Erin B. ; Whitmer, Rachel A. ; Yaffe, Kristine ; Yang, Qiong ; Zhao, Wei ; Gudnason, Vilmundur ; Launer, Lenore J. ; Fitzpatrick, Annette L. ; Psaty, Bruce M. ; Fornage, Myriam ; Arfan Ikram, M. ; van Duijn, Cornelia M. ; Seshadri, Sudha ; Mosley, Thomas H. ; Deary, Ian J.

Izvornik
Translational Psychiatry (2158-3188) 11 (2021), 1; 613, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
GENOME-WIDE ASSOCIATION ; UBIQUITYLATED INCLUSIONS ; PARKINSONS-DISEASE ; ALZHEIMERS-DISEASE ; DORFIN LOCALIZES ; RISK-FACTORS ; LEWY BODIES ; PROTEIN ; DEMENTIA ; HEALTH

Sažetak
Measures of information processing speed vary between individuals and decline with age. Studies of aging twins suggest heritability may be as high as 67%. The Illumina HumanExome Bead Chip genotyping array was used to examine the association of rare coding variants with performance on the Digit-Symbol Substitution Test (DSST) in community-dwelling adults participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. DSST scores were available for 30, 576 individuals of European ancestry from nine cohorts and for 5758 individuals of African ancestry from four cohorts who were older than 45 years and free of dementia and clinical stroke. Linear regression models adjusted for age and gender were used for analysis of single genetic variants, and the T5, T1, and T01 burden tests that aggregate the number of rare alleles by gene were also applied. Secondary analyses included further adjustment for education. Meta-analyses to combine cohort- specific results were carried out separately for each ancestry group. Variants in RNF19A reached the threshold for statistical significance (p = 2.01 x 10(-6)) using the T01 test in individuals of European descent. RNF19A belongs to the class of E3 ubiquitin ligases that confer substrate specificity when proteins are ubiquitinated and targeted for degradation through the 26S proteasome. Variants in SLC22A7 and OR51A7 were suggestively associated with DSST scores after adjustment for education for African-American participants and in the European cohorts, respectively. Further functional characterization of its substrates will be required to confirm the role of RNF19A in cognitive function.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Avatar Url Igor Rudan (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Bressler, Jan; Davies, Gail; Smith, Albert V.; Saba, Yasaman; Bis, Joshua C.; Jian, Xueqiu; Hayward, Caroline; Yanek, Lisa; Smith, Jennifer A.; Mirza, Saira S. et al.
Association of low-frequency and rare coding variants with information processing speed // Translational Psychiatry, 11 (2021), 1; 613, 10 doi:10.1038/s41398-021-01736-6 (međunarodna recenzija, članak, znanstveni)
Bressler, J., Davies, G., Smith, A., Saba, Y., Bis, J., Jian, X., Hayward, C., Yanek, L., Smith, J. & Mirza, S. (2021) Association of low-frequency and rare coding variants with information processing speed. Translational Psychiatry, 11 (1), 613, 10 doi:10.1038/s41398-021-01736-6.
@article{article, author = {Bressler, Jan and Davies, Gail and Smith, Albert V. and Saba, Yasaman and Bis, Joshua C. and Jian, Xueqiu and Hayward, Caroline and Yanek, Lisa and Smith, Jennifer A. and Mirza, Saira S. and Wang, Ruiqi and Adams, Hieab H. H. and Becker, Diane and Boerwinkle, Eric and Campbell, Archie and Cox, Simon R. and Eiriksdottir, Gudny and Fawns-Ritchie, Chloe and Gottesman, Rebecca F. and Grove, Megan L. and Guo, Xiuqing and Hofer, Edith and Kardia, Sharon L. R. and Knol, Maria J. and Koini, Marisa and Lopez, Oscar L. and Marioni, Riccardo E. and Nyquist, Paul and Pattie, Alison and Polasek, Ozren and Porteous, David J. and Rudan, Igor and Satizabal, Claudia L. and Schmidt, Helena and Schmidt, Reinhold and Sidney, Stephen and Simino, Jeannette and Smith, Blair H. and Turner, Stephen T. and van der Lee, Sven J. and Ware, Erin B. and Whitmer, Rachel A. and Yaffe, Kristine and Yang, Qiong and Zhao, Wei and Gudnason, Vilmundur and Launer, Lenore J. and Fitzpatrick, Annette L. and Psaty, Bruce M. and Fornage, Myriam and Arfan Ikram, M. and van Duijn, Cornelia M. and Seshadri, Sudha and Mosley, Thomas H. and Deary, Ian J.}, year = {2021}, pages = {10}, DOI = {10.1038/s41398-021-01736-6}, chapter = {613}, keywords = {GENOME-WIDE ASSOCIATION, UBIQUITYLATED INCLUSIONS, PARKINSONS-DISEASE, ALZHEIMERS-DISEASE, DORFIN LOCALIZES, RISK-FACTORS, LEWY BODIES, PROTEIN, DEMENTIA, HEALTH}, journal = {Translational Psychiatry}, doi = {10.1038/s41398-021-01736-6}, volume = {11}, number = {1}, issn = {2158-3188}, title = {Association of low-frequency and rare coding variants with information processing speed}, keyword = {GENOME-WIDE ASSOCIATION, UBIQUITYLATED INCLUSIONS, PARKINSONS-DISEASE, ALZHEIMERS-DISEASE, DORFIN LOCALIZES, RISK-FACTORS, LEWY BODIES, PROTEIN, DEMENTIA, HEALTH}, chapternumber = {613} }
@article{article, author = {Bressler, Jan and Davies, Gail and Smith, Albert V. and Saba, Yasaman and Bis, Joshua C. and Jian, Xueqiu and Hayward, Caroline and Yanek, Lisa and Smith, Jennifer A. and Mirza, Saira S. and Wang, Ruiqi and Adams, Hieab H. H. and Becker, Diane and Boerwinkle, Eric and Campbell, Archie and Cox, Simon R. and Eiriksdottir, Gudny and Fawns-Ritchie, Chloe and Gottesman, Rebecca F. and Grove, Megan L. and Guo, Xiuqing and Hofer, Edith and Kardia, Sharon L. R. and Knol, Maria J. and Koini, Marisa and Lopez, Oscar L. and Marioni, Riccardo E. and Nyquist, Paul and Pattie, Alison and Polasek, Ozren and Porteous, David J. and Rudan, Igor and Satizabal, Claudia L. and Schmidt, Helena and Schmidt, Reinhold and Sidney, Stephen and Simino, Jeannette and Smith, Blair H. and Turner, Stephen T. and van der Lee, Sven J. and Ware, Erin B. and Whitmer, Rachel A. and Yaffe, Kristine and Yang, Qiong and Zhao, Wei and Gudnason, Vilmundur and Launer, Lenore J. and Fitzpatrick, Annette L. and Psaty, Bruce M. and Fornage, Myriam and Arfan Ikram, M. and van Duijn, Cornelia M. and Seshadri, Sudha and Mosley, Thomas H. and Deary, Ian J.}, year = {2021}, pages = {10}, DOI = {10.1038/s41398-021-01736-6}, chapter = {613}, keywords = {GENOME-WIDE ASSOCIATION, UBIQUITYLATED INCLUSIONS, PARKINSONS-DISEASE, ALZHEIMERS-DISEASE, DORFIN LOCALIZES, RISK-FACTORS, LEWY BODIES, PROTEIN, DEMENTIA, HEALTH}, journal = {Translational Psychiatry}, doi = {10.1038/s41398-021-01736-6}, volume = {11}, number = {1}, issn = {2158-3188}, title = {Association of low-frequency and rare coding variants with information processing speed}, keyword = {GENOME-WIDE ASSOCIATION, UBIQUITYLATED INCLUSIONS, PARKINSONS-DISEASE, ALZHEIMERS-DISEASE, DORFIN LOCALIZES, RISK-FACTORS, LEWY BODIES, PROTEIN, DEMENTIA, HEALTH}, chapternumber = {613} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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