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Pregled bibliografske jedinice broj: 1250852

ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals

Bihlmeyer, Nathan A.; Brody, Jennifer A.; Smith, Albert Vernon; Warren, Helen R.; Lin, Honghuang; Isaacs, Aaron; Liu, Ching-Ti; Marten, Jonathan; Radmanesh, Farid; Hall, Leanne M. et al.
ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals // Circulation: Genomic and Precision Medicine, 11 (2018), 1; e001758, 10 doi:10.1161/circgen.117.001758 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1250852 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals

Autori
Bihlmeyer, Nathan A. ; Brody, Jennifer A. ; Smith, Albert Vernon ; Warren, Helen R. ; Lin, Honghuang ; Isaacs, Aaron ; Liu, Ching-Ti ; Marten, Jonathan ; Radmanesh, Farid ; Hall, Leanne M. ; Grarup, Niels ; Mei, Hao ; Müller-Nurasyid, Martina ; Huffman, Jennifer E. ; Verweij, Niek ; Guo, Xiuqing ; Yao, Jie ; Li-Gao, Ruifang ; van den Berg, Marten ; Weiss, Stefan ; Prins, Bram P. ; van Setten, Jessica ; Haessler, Jeffrey ; Lyytikäinen, Leo-Pekka ; Li, Man ; Alonso, Alvaro ; Soliman, Elsayed Z. ; Bis, Joshua C. ; Austin, Tom ; Chen, Yii-Der Ida ; Psaty, Bruce M. ; Harrris, Tamara B. ; Launer, Lenore J. ; Padmanabhan, Sandosh ; Dominiczak, Anna ; Huang, Paul L. ; Xie, Zhijun ; Ellinor, Patrick T. ; Kors, Jan A. ; Campbell, Archie ; Murray, Alison D. ; Nelson, Christopher P. ; Tobin, Martin D. ; Bork-Jensen, Jette ; Hansen, Torben ; Pedersen, Oluf ; Linneberg, Allan ; Sinner, Moritz F. ; Peters, Annette ; Waldenberger, Melanie ; Meitinger, Thomas ; Perz, Siegfried ; Kolcic, Ivana ; Rudan, Igor ; de Boer, Rudolf A. ; van der Meer, Peter ; Lin, Henry J. ; Taylor, Kent D. ; de Mutsert, Renée ; Trompet, Stella ; Jukema, J. Wouter ; Maan, Arie C. ; Stricker, Bruno H.C. ; Rivadeneira, Fernando ; Uitterlinden, André ; Völker, Uwe ; Homuth, Georg ; Völzke, Henry ; Felix, Stephan B. ; Mangino, Massimo ; Spector, Timothy D. ; Bots, Michiel L. ; Perez, Marco ; Raitakari, Olli T. ; Kähönen, Mika ; Mononen, Nina ; Gudnason, Vilmundur ; Munroe, Patricia B. ; Lubitz, Steven A. ; van Duijn, Cornelia M. ; Newton-Cheh, Christopher H. ; Hayward, Caroline ; Rosand, Jonathan ; Samani, Nilesh J. ; Kanters, Jørgen K. ; Wilson, James G. ; Kääb, Stefan ; Polasek, Ozren ; van der Harst, Pim ; Heckbert, Susan R. ; Rotter, Jerome I. ; Mook-Kanamori, Dennis O. ; Eijgelsheim, Mark ; Dörr, Marcus ; Jamshidi, Yalda ; Asselbergs, Folkert W. ; Kooperberg, Charles ; Lehtimäki, Terho ; Arking, Dan E. ; Sotoodehnia, Nona

Izvornik
Circulation: Genomic and Precision Medicine (2574-8300) 11 (2018), 1; E001758, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
arrhythmias, cardiac ; death, sudden, cardiac ; genetics ; genome ; humans

Sažetak
BACKGROUND: QT interval, measured through a standard ECG, captures the time it takes for the cardiac ventricles to depolarize and repolarize. JT interval is the component of the QT interval that reflects ventricular repolarization alone. Prolonged QT interval has been linked to higher risk of sudden cardiac arrest. METHODS AND RESULTS: We performed an ExomeChip-wide analysis for both QT and JT intervals, including 209 449 variants, both common and rare, in 17 341 genes from the Illumina Infinium HumanExome BeadChip. We identified 10 loci that modulate QT and JT interval duration that have not been previously reported in the literature using single-variant statistical models in a meta-analysis of 95 626 individuals from 23 cohorts (comprised 83 884 European ancestry individuals, 9610 blacks, 1382 Hispanics, and 750 Asians). This brings the total number of ventricular repolarization associated loci to 45. In addition, our approach of using coding variants has highlighted the role of 17 specific genes for involvement in ventricular repolarization, 7 of which are in novel loci. CONCLUSIONS: Our analyses show a role for myocyte internal structure and interconnections in modulating QT interval duration, adding to previous known roles of potassium, sodium, and calcium ion regulation, as well as autonomic control. We anticipate that these discoveries will open new paths to the goal of making novel remedies for the prevention of lethal ventricular arrhythmias and sudden cardiac arrest.

Izvorni jezik
Engleski



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Avatar Url Igor Rudan (autor)

Avatar Url Ivana Kolčić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Bihlmeyer, Nathan A.; Brody, Jennifer A.; Smith, Albert Vernon; Warren, Helen R.; Lin, Honghuang; Isaacs, Aaron; Liu, Ching-Ti; Marten, Jonathan; Radmanesh, Farid; Hall, Leanne M. et al.
ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals // Circulation: Genomic and Precision Medicine, 11 (2018), 1; e001758, 10 doi:10.1161/circgen.117.001758 (međunarodna recenzija, članak, znanstveni)
Bihlmeyer, N., Brody, J., Smith, A., Warren, H., Lin, H., Isaacs, A., Liu, C., Marten, J., Radmanesh, F. & Hall, L. (2018) ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals. Circulation: Genomic and Precision Medicine, 11 (1), e001758, 10 doi:10.1161/circgen.117.001758.
@article{article, author = {Bihlmeyer, Nathan A. and Brody, Jennifer A. and Smith, Albert Vernon and Warren, Helen R. and Lin, Honghuang and Isaacs, Aaron and Liu, Ching-Ti and Marten, Jonathan and Radmanesh, Farid and Hall, Leanne M. and Grarup, Niels and Mei, Hao and M\"{u}ller-Nurasyid, Martina and Huffman, Jennifer E. and Verweij, Niek and Guo, Xiuqing and Yao, Jie and Li-Gao, Ruifang and van den Berg, Marten and Weiss, Stefan and Prins, Bram P. and van Setten, Jessica and Haessler, Jeffrey and Lyytik\"{a}inen, Leo-Pekka and Li, Man and Alonso, Alvaro and Soliman, Elsayed Z. and Bis, Joshua C. and Austin, Tom and Chen, Yii-Der Ida and Psaty, Bruce M. and Harrris, Tamara B. and Launer, Lenore J. and Padmanabhan, Sandosh and Dominiczak, Anna and Huang, Paul L. and Xie, Zhijun and Ellinor, Patrick T. and Kors, Jan A. and Campbell, Archie and Murray, Alison D. and Nelson, Christopher P. and Tobin, Martin D. and Bork-Jensen, Jette and Hansen, Torben and Pedersen, Oluf and Linneberg, Allan and Sinner, Moritz F. and Peters, Annette and Waldenberger, Melanie and Meitinger, Thomas and Perz, Siegfried and Kolcic, Ivana and Rudan, Igor and de Boer, Rudolf A. and van der Meer, Peter and Lin, Henry J. and Taylor, Kent D. and de Mutsert, Ren\'{e}e and Trompet, Stella and Jukema, J. Wouter and Maan, Arie C. and Stricker, Bruno H.C. and Rivadeneira, Fernando and Uitterlinden, Andr\'{e} and V\"{o}lker, Uwe and Homuth, Georg and V\"{o}lzke, Henry and Felix, Stephan B. and Mangino, Massimo and Spector, Timothy D. and Bots, Michiel L. and Perez, Marco and Raitakari, Olli T. and K\"{a}h\"{o}nen, Mika and Mononen, Nina and Gudnason, Vilmundur and Munroe, Patricia B. and Lubitz, Steven A. and van Duijn, Cornelia M. and Newton-Cheh, Christopher H. and Hayward, Caroline and Rosand, Jonathan and Samani, Nilesh J. and Kanters, J\orgen K. and Wilson, James G. and K\"{a}\"{a}b, Stefan and Polasek, Ozren and van der Harst, Pim and Heckbert, Susan R. and Rotter, Jerome I. and Mook-Kanamori, Dennis O. and Eijgelsheim, Mark and D\"{o}rr, Marcus and Jamshidi, Yalda and Asselbergs, Folkert W. and Kooperberg, Charles and Lehtim\"{a}ki, Terho and Arking, Dan E. and Sotoodehnia, Nona}, year = {2018}, pages = {10}, DOI = {10.1161/circgen.117.001758}, chapter = {e001758}, keywords = {arrhythmias, cardiac, death, sudden, cardiac, genetics, genome, humans}, journal = {Circulation: Genomic and Precision Medicine}, doi = {10.1161/circgen.117.001758}, volume = {11}, number = {1}, issn = {2574-8300}, title = {ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals}, keyword = {arrhythmias, cardiac, death, sudden, cardiac, genetics, genome, humans}, chapternumber = {e001758} }
@article{article, author = {Bihlmeyer, Nathan A. and Brody, Jennifer A. and Smith, Albert Vernon and Warren, Helen R. and Lin, Honghuang and Isaacs, Aaron and Liu, Ching-Ti and Marten, Jonathan and Radmanesh, Farid and Hall, Leanne M. and Grarup, Niels and Mei, Hao and M\"{u}ller-Nurasyid, Martina and Huffman, Jennifer E. and Verweij, Niek and Guo, Xiuqing and Yao, Jie and Li-Gao, Ruifang and van den Berg, Marten and Weiss, Stefan and Prins, Bram P. and van Setten, Jessica and Haessler, Jeffrey and Lyytik\"{a}inen, Leo-Pekka and Li, Man and Alonso, Alvaro and Soliman, Elsayed Z. and Bis, Joshua C. and Austin, Tom and Chen, Yii-Der Ida and Psaty, Bruce M. and Harrris, Tamara B. and Launer, Lenore J. and Padmanabhan, Sandosh and Dominiczak, Anna and Huang, Paul L. and Xie, Zhijun and Ellinor, Patrick T. and Kors, Jan A. and Campbell, Archie and Murray, Alison D. and Nelson, Christopher P. and Tobin, Martin D. and Bork-Jensen, Jette and Hansen, Torben and Pedersen, Oluf and Linneberg, Allan and Sinner, Moritz F. and Peters, Annette and Waldenberger, Melanie and Meitinger, Thomas and Perz, Siegfried and Kolcic, Ivana and Rudan, Igor and de Boer, Rudolf A. and van der Meer, Peter and Lin, Henry J. and Taylor, Kent D. and de Mutsert, Ren\'{e}e and Trompet, Stella and Jukema, J. Wouter and Maan, Arie C. and Stricker, Bruno H.C. and Rivadeneira, Fernando and Uitterlinden, Andr\'{e} and V\"{o}lker, Uwe and Homuth, Georg and V\"{o}lzke, Henry and Felix, Stephan B. and Mangino, Massimo and Spector, Timothy D. and Bots, Michiel L. and Perez, Marco and Raitakari, Olli T. and K\"{a}h\"{o}nen, Mika and Mononen, Nina and Gudnason, Vilmundur and Munroe, Patricia B. and Lubitz, Steven A. and van Duijn, Cornelia M. and Newton-Cheh, Christopher H. and Hayward, Caroline and Rosand, Jonathan and Samani, Nilesh J. and Kanters, J\orgen K. and Wilson, James G. and K\"{a}\"{a}b, Stefan and Polasek, Ozren and van der Harst, Pim and Heckbert, Susan R. and Rotter, Jerome I. and Mook-Kanamori, Dennis O. and Eijgelsheim, Mark and D\"{o}rr, Marcus and Jamshidi, Yalda and Asselbergs, Folkert W. and Kooperberg, Charles and Lehtim\"{a}ki, Terho and Arking, Dan E. and Sotoodehnia, Nona}, year = {2018}, pages = {10}, DOI = {10.1161/circgen.117.001758}, chapter = {e001758}, keywords = {arrhythmias, cardiac, death, sudden, cardiac, genetics, genome, humans}, journal = {Circulation: Genomic and Precision Medicine}, doi = {10.1161/circgen.117.001758}, volume = {11}, number = {1}, issn = {2574-8300}, title = {ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals}, keyword = {arrhythmias, cardiac, death, sudden, cardiac, genetics, genome, humans}, chapternumber = {e001758} }

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