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Pregled bibliografske jedinice broj: 1250846

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals

(COGENT-Kidney Consortium ; EPIC-InterAct Consortium ; Understanding Soc Sci Grp ; Lifelines Cohort) Bentley, Amy R.; Sung, Yun J.; Brown, Michael R.; Winkler, Thomas W. et al.
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals // Nature Genetics, 51 (2019), 4; 636-648 doi:10.1038/s41588-019-0378-y (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1250846 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals
(Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids)

Autori
Bentley, Amy R. ; Sung, Yun J. ; Brown, Michael R. ; Winkler, Thomas W. et al.

Kolaboracija
COGENT-Kidney Consortium ; EPIC-InterAct Consortium ; Understanding Soc Sci Grp ; Lifelines Cohort

Izvornik
Nature Genetics (1061-4036) 51 (2019), 4; 636-648

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ENVIRONMENT INTERACTION ; GENOTYPE IMPUTATION ; NICOTINE METABOLISM ; RISK LOCI ; METAANALYSIS ; ARCHITECTURE ; CHOLESTEROL ; CIGARETTES ; VARIANTS ; SUSCEPTIBILITY

Sažetak
The concentrations of high- and low-density- lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome- wide gene-smoking interaction study in 133, 805 individuals with follow-up in an additional 253, 467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ivana Kolčić (autor)

Avatar Url Ozren Polašek (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

(COGENT-Kidney Consortium ; EPIC-InterAct Consortium ; Understanding Soc Sci Grp ; Lifelines Cohort) Bentley, Amy R.; Sung, Yun J.; Brown, Michael R.; Winkler, Thomas W. et al.
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals // Nature Genetics, 51 (2019), 4; 636-648 doi:10.1038/s41588-019-0378-y (međunarodna recenzija, članak, znanstveni)
(COGENT-Kidney Consortium ; EPIC-InterAct Consortium ; Understanding Soc Sci Grp ; Lifelines Cohort) (COGENT-Kidney Consortium, EPIC-InterAct Consortium, Understanding Soc Sci Grp, Lifelines Cohort) Bentley, A., Sung, Y., Brown, M. & Winkler, T. (2019) Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals. Nature Genetics, 51 (4), 636-648 doi:10.1038/s41588-019-0378-y.
@article{article, author = {Bentley, Amy R. and Sung, Yun J. and Brown, Michael R. and Winkler, Thomas W. et al.}, year = {2019}, pages = {636-648}, DOI = {10.1038/s41588-019-0378-y}, keywords = {ENVIRONMENT INTERACTION, GENOTYPE IMPUTATION, NICOTINE METABOLISM, RISK LOCI, METAANALYSIS, ARCHITECTURE, CHOLESTEROL, CIGARETTES, VARIANTS, SUSCEPTIBILITY}, journal = {Nature Genetics}, doi = {10.1038/s41588-019-0378-y}, volume = {51}, number = {4}, issn = {1061-4036}, title = {Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals}, keyword = {ENVIRONMENT INTERACTION, GENOTYPE IMPUTATION, NICOTINE METABOLISM, RISK LOCI, METAANALYSIS, ARCHITECTURE, CHOLESTEROL, CIGARETTES, VARIANTS, SUSCEPTIBILITY} }
@article{article, author = {Bentley, Amy R. and Sung, Yun J. and Brown, Michael R. and Winkler, Thomas W. et al.}, year = {2019}, pages = {636-648}, DOI = {10.1038/s41588-019-0378-y}, keywords = {ENVIRONMENT INTERACTION, GENOTYPE IMPUTATION, NICOTINE METABOLISM, RISK LOCI, METAANALYSIS, ARCHITECTURE, CHOLESTEROL, CIGARETTES, VARIANTS, SUSCEPTIBILITY}, journal = {Nature Genetics}, doi = {10.1038/s41588-019-0378-y}, volume = {51}, number = {4}, issn = {1061-4036}, title = {Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids}, keyword = {ENVIRONMENT INTERACTION, GENOTYPE IMPUTATION, NICOTINE METABOLISM, RISK LOCI, METAANALYSIS, ARCHITECTURE, CHOLESTEROL, CIGARETTES, VARIANTS, SUSCEPTIBILITY} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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