Naslov
Competitive apnea and its effect on the human brain: focus on the redox regulation of blood‐ brain barrier permeability and neuronal‐ parenchymal integrity

Autori
Bain, Anthony R. ; Ainslie, Philip N. ; Hoiland, Ryan L. ; Barak, Otto F. ; Drvis, Ivan ; Stembridge, Mike ; MacLeod, Douglas M. ; McEneny, Jane ; Stacey, Benjamin S. ; Tuaillon, Eduoard ; Marchi, Nicola ; De Maudave, Alexis Fayd'Herbe ; Dujic, Zeljko ; MacLeod, David B. ; Bailey, Damian M.

Izvornik
The FASEB Journal (0892-6638) 32 (2018), 4; 2305-2314

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
hypoxia ; hypercapnea ; hypertension ; cerebral perfusion ; free radicals

Sažetak
Static apnea provides a unique model that combines transient hypertension, hypercapnia, and severe hypoxemia. With apnea durations exceeding 5 min, the purpose of the present study was to determine how that affects cerebral free-radical formation and the corresponding implications for brain structure and function. Measurements were obtained before and following a maximal apnea in 14 divers with transcerebral exchange kinetics, measured as the product of global cerebral blood flow (duplex ultrasound) and radial arterial to internal jugular venous concentration differences (a-v(D)). Apnea increased the systemic (arterial) and, to a greater extent, the regional (jugular venous) concentration of the ascorbate free radical, resulting in a shift from net cerebral uptake to output (P < 0.05). Peroxidation (lipid hydroperoxides, LDL oxidation), NO bioactivity, and S100 beta were correspondingly enhanced (P < 0.05), the latter interpreted as minor and not a pathologic disruption of the blood-brain barrier. However, those changes were insufficient to cause neuronal-parenchymal damage confirmed by the lack of change in the a-v(D) of neuron-specific enolase and human myelin basic protein (P > 0.05). Collectively, these observations suggest that increased cerebral oxidative stress following prolonged apnea in trained divers may reflect a functional physiologic response, rather than a purely maladaptive phenomenon.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA