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Pregled bibliografske jedinice broj: 1249517

Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval

Lin, Honghuang; van Setten, Jessica; Smith, Albert V.; Bihlmeyer, Nathan A.; Warren, Helen R.; Brody, Jennifer A.; Radmanesh, Farid; Hall, Leanne; Grarup, Niels; Mueller-Nurasyid, Martina et al.
Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval // CIRCULATION-GENOMIC AND PRECISION MEDICINE, 11 (2018), 5; e002037, 11 doi:10.1161/CIRCGEN.117.002037 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1249517 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval

Autori
Lin, Honghuang ; van Setten, Jessica ; Smith, Albert V. ; Bihlmeyer, Nathan A. ; Warren, Helen R. ; Brody, Jennifer A. ; Radmanesh, Farid ; Hall, Leanne ; Grarup, Niels ; Mueller-Nurasyid, Martina ; Boutin, Thibaud ; Verweij, Niek ; Lin, Henry J. ; Li-Gao, Ruifang ; van den Berg, Marten E. ; Marten, Jonathan ; Weiss, Stefan ; Prins, Bram P. ; Haessler, Jeffrey ; Lyytikainen, Leo-Pekka ; Mei, Hao ; Harris, Tamara B. ; Launer, Lenore J. ; Li, Man ; Alonso, Alvaro ; Soliman, Elsayed Z. ; Connell, John M. ; Huang, Paul L. ; Weng, Lu-Chen ; Jameson, Heather S. ; Hucker, William ; Hanley, Alan ; Tucker, Nathan R. ; Chen, Yii-Der Ida ; Bis, Joshua C. ; Rice, Kenneth M. ; Sitlani, Colleen M. ; Kors, Jan A. ; Xie, Zhijun ; Wen, Chengping ; Magnani, Jared W. ; Nelson, Christopher P. ; Kanters, Jorgen K. ; Sinner, Moritz F. ; Strauch, Konstantin ; Peters, Annette ; Waldenberger, Melanie ; Meitinger, Thomas ; Bork-Jensen, Jette ; Pedersen, Oluf ; Linneberg, Allan ; Rudan, Igor ; de Boer, Rudolf A. ; van der Meer, Peter ; Yao, Jie ; Guo, Xiuqing ; Taylor, Kent D. ; Sotoodehnia, Nona ; Rotter, Jerome I. ; Mook- Kanamori, Dennis O. ; Trompet, Stella ; Rivadeneira, Fernando ; Uitterlinden, Andre ; Eijgelsheim, Mark ; Padmanabhan, Sandosh ; Smith, Blair H. ; Volzke, Henry ; Mangino, Massimo ; Spector, Timothy D. ; Bots, Michiel L. ; Perez, Marco ; Kahonen, Mika ; Raitakari, Olli T. ; Gudnason, Vilmundur ; Arking, Dan E. ; Munroe, Patricia B. ; Psaty, Bruce M. ; van Duijn, Cornelia M. ; Benjamin, Emelia J. ; Rosand, Jonathan ; Samani, Nilesh J. ; Hansen, Torben ; Kaeaeb, Stefan ; Polašek, Ozren ; van der Harst, Pim ; Heckbert, Susan R. ; Jukema, J. Wouter ; Stricker, Bruno H. ; Hayward, Caroline ; Doerr, Marcus ; Jamshidi, Yalda ; Asselbergs, Folkert W. ; Kooperberg, Charles ; Lehtimaki, Terho ; Wilson, James G. ; Ellinor, Patrick T. ; Lubitz, Steven A. ; Isaacs, Aaron

Izvornik
CIRCULATION-GENOMIC AND PRECISION MEDICINE (2574-8300) 11 (2018), 5; E002037, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
atrioventricular node ; genetic loci ; genome-wide association study

Sažetak
BACKGROUND: Electrical conduction from the cardiac sinoatrial node to the ventricles is critical for normal heart function. Genome-wide association studies have identified more than a dozen common genetic loci that are associated with PR interval. However, it is unclear whether rare and low- frequency variants also contribute to PR interval heritability. METHODS: We performed large-scale meta-analyses of the PR interval that included 83 367 participants of European ancestry and 9436 of African ancestry. We examined both common and rare variants associated with the PR interval. RESULTS: We identified 31 genetic loci that were significantly associated with PR interval after Bonferroni correction (P<1.2x10(-6)), including 11 novel loci that have not been reported previously. Many of these loci are involved in heart morphogenesis. In gene-based analysis, we found that multiple rare variants at MYH6 (P=5.9x10(-11)) and SCN5A (P=1.1x10(-7)) were associated with PR interval. SCN5A locus also was implicated in the common variant analysis, whereas MYH6 was a novel locus. CONCLUSIONS: We identified common variants at 11 novel loci and rare variants within 2 gene regions that were significantly associated with PR interval. Our findings provide novel insights to the current understanding of atrioventricular conduction, which is critical for cardiac activity and an important determinant of health.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Avatar Url Igor Rudan (autor)

Poveznice na cjeloviti tekst rada:

doi www.ahajournals.org

Citiraj ovu publikaciju:

Lin, Honghuang; van Setten, Jessica; Smith, Albert V.; Bihlmeyer, Nathan A.; Warren, Helen R.; Brody, Jennifer A.; Radmanesh, Farid; Hall, Leanne; Grarup, Niels; Mueller-Nurasyid, Martina et al.
Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval // CIRCULATION-GENOMIC AND PRECISION MEDICINE, 11 (2018), 5; e002037, 11 doi:10.1161/CIRCGEN.117.002037 (međunarodna recenzija, članak, znanstveni)
Lin, H., van Setten, J., Smith, A., Bihlmeyer, N., Warren, H., Brody, J., Radmanesh, F., Hall, L., Grarup, N. & Mueller-Nurasyid, M. (2018) Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval. CIRCULATION-GENOMIC AND PRECISION MEDICINE, 11 (5), e002037, 11 doi:10.1161/CIRCGEN.117.002037.
@article{article, author = {Lin, Honghuang and van Setten, Jessica and Smith, Albert V. and Bihlmeyer, Nathan A. and Warren, Helen R. and Brody, Jennifer A. and Radmanesh, Farid and Hall, Leanne and Grarup, Niels and Mueller-Nurasyid, Martina and Boutin, Thibaud and Verweij, Niek and Lin, Henry J. and Li-Gao, Ruifang and van den Berg, Marten E. and Marten, Jonathan and Weiss, Stefan and Prins, Bram P. and Haessler, Jeffrey and Lyytikainen, Leo-Pekka and Mei, Hao and Harris, Tamara B. and Launer, Lenore J. and Li, Man and Alonso, Alvaro and Soliman, Elsayed Z. and Connell, John M. and Huang, Paul L. and Weng, Lu-Chen and Jameson, Heather S. and Hucker, William and Hanley, Alan and Tucker, Nathan R. and Chen, Yii-Der Ida and Bis, Joshua C. and Rice, Kenneth M. and Sitlani, Colleen M. and Kors, Jan A. and Xie, Zhijun and Wen, Chengping and Magnani, Jared W. and Nelson, Christopher P. and Kanters, Jorgen K. and Sinner, Moritz F. and Strauch, Konstantin and Peters, Annette and Waldenberger, Melanie and Meitinger, Thomas and Bork-Jensen, Jette and Pedersen, Oluf and Linneberg, Allan and Rudan, Igor and de Boer, Rudolf A. and van der Meer, Peter and Yao, Jie and Guo, Xiuqing and Taylor, Kent D. and Sotoodehnia, Nona and Rotter, Jerome I. and Mook- Kanamori, Dennis O. and Trompet, Stella and Rivadeneira, Fernando and Uitterlinden, Andre and Eijgelsheim, Mark and Padmanabhan, Sandosh and Smith, Blair H. and Volzke, Henry and Mangino, Massimo and Spector, Timothy D. and Bots, Michiel L. and Perez, Marco and Kahonen, Mika and Raitakari, Olli T. and Gudnason, Vilmundur and Arking, Dan E. and Munroe, Patricia B. and Psaty, Bruce M. and van Duijn, Cornelia M. and Benjamin, Emelia J. and Rosand, Jonathan and Samani, Nilesh J. and Hansen, Torben and Kaeaeb, Stefan and Pola\v{s}ek, Ozren and van der Harst, Pim and Heckbert, Susan R. and Jukema, J. Wouter and Stricker, Bruno H. and Hayward, Caroline and Doerr, Marcus and Jamshidi, Yalda and Asselbergs, Folkert W. and Kooperberg, Charles and Lehtimaki, Terho and Wilson, James G. and Ellinor, Patrick T. and Lubitz, Steven A. and Isaacs, Aaron}, year = {2018}, pages = {11}, DOI = {10.1161/CIRCGEN.117.002037}, chapter = {e002037}, keywords = {atrioventricular node, genetic loci, genome-wide association study}, journal = {CIRCULATION-GENOMIC AND PRECISION MEDICINE}, doi = {10.1161/CIRCGEN.117.002037}, volume = {11}, number = {5}, issn = {2574-8300}, title = {Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval}, keyword = {atrioventricular node, genetic loci, genome-wide association study}, chapternumber = {e002037} }
@article{article, author = {Lin, Honghuang and van Setten, Jessica and Smith, Albert V. and Bihlmeyer, Nathan A. and Warren, Helen R. and Brody, Jennifer A. and Radmanesh, Farid and Hall, Leanne and Grarup, Niels and Mueller-Nurasyid, Martina and Boutin, Thibaud and Verweij, Niek and Lin, Henry J. and Li-Gao, Ruifang and van den Berg, Marten E. and Marten, Jonathan and Weiss, Stefan and Prins, Bram P. and Haessler, Jeffrey and Lyytikainen, Leo-Pekka and Mei, Hao and Harris, Tamara B. and Launer, Lenore J. and Li, Man and Alonso, Alvaro and Soliman, Elsayed Z. and Connell, John M. and Huang, Paul L. and Weng, Lu-Chen and Jameson, Heather S. and Hucker, William and Hanley, Alan and Tucker, Nathan R. and Chen, Yii-Der Ida and Bis, Joshua C. and Rice, Kenneth M. and Sitlani, Colleen M. and Kors, Jan A. and Xie, Zhijun and Wen, Chengping and Magnani, Jared W. and Nelson, Christopher P. and Kanters, Jorgen K. and Sinner, Moritz F. and Strauch, Konstantin and Peters, Annette and Waldenberger, Melanie and Meitinger, Thomas and Bork-Jensen, Jette and Pedersen, Oluf and Linneberg, Allan and Rudan, Igor and de Boer, Rudolf A. and van der Meer, Peter and Yao, Jie and Guo, Xiuqing and Taylor, Kent D. and Sotoodehnia, Nona and Rotter, Jerome I. and Mook- Kanamori, Dennis O. and Trompet, Stella and Rivadeneira, Fernando and Uitterlinden, Andre and Eijgelsheim, Mark and Padmanabhan, Sandosh and Smith, Blair H. and Volzke, Henry and Mangino, Massimo and Spector, Timothy D. and Bots, Michiel L. and Perez, Marco and Kahonen, Mika and Raitakari, Olli T. and Gudnason, Vilmundur and Arking, Dan E. and Munroe, Patricia B. and Psaty, Bruce M. and van Duijn, Cornelia M. and Benjamin, Emelia J. and Rosand, Jonathan and Samani, Nilesh J. and Hansen, Torben and Kaeaeb, Stefan and Pola\v{s}ek, Ozren and van der Harst, Pim and Heckbert, Susan R. and Jukema, J. Wouter and Stricker, Bruno H. and Hayward, Caroline and Doerr, Marcus and Jamshidi, Yalda and Asselbergs, Folkert W. and Kooperberg, Charles and Lehtimaki, Terho and Wilson, James G. and Ellinor, Patrick T. and Lubitz, Steven A. and Isaacs, Aaron}, year = {2018}, pages = {11}, DOI = {10.1161/CIRCGEN.117.002037}, chapter = {e002037}, keywords = {atrioventricular node, genetic loci, genome-wide association study}, journal = {CIRCULATION-GENOMIC AND PRECISION MEDICINE}, doi = {10.1161/CIRCGEN.117.002037}, volume = {11}, number = {5}, issn = {2574-8300}, title = {Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval}, keyword = {atrioventricular node, genetic loci, genome-wide association study}, chapternumber = {e002037} }

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