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Pregled bibliografske jedinice broj: 1249445

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

van Setten, Jessica; Brody, Jennifer A.; Jamshidi, Yalda; Swenson, Brenton R.; Butler, Anne M.; Campbell, Harry; Del Greco, Fabiola M.; Evans, Daniel S.; Gibson, Quince; Gudbjartsson, Daniel F. et al.
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity // Nature communications, 9 (2018), 2904, 11 doi:10.1038/s41467-018-04766-9 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1249445 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

Autori
Van Setten, Jessica ; Brody, Jennifer A. ; Jamshidi, Yalda ; Swenson, Brenton R. ; Butler, Anne M. ; Campbell, Harry ; Del Greco, Fabiola M. ; Evans, Daniel S. ; Gibson, Quince ; Gudbjartsson, Daniel F. ; Kerr, Kathleen F. ; Krijthe, Bouwe P. ; Lyytikainen, Leo-Pekka ; Mueller, Christian ; Mueller-Nurasyid, Martina ; Nolte, Ilja M. ; Padmanabhan, Sandosh ; Ritchie, Marylyn D. ; Robino, Antonietta ; Smith, Albert V. ; Steri, Maristella ; Tanaka, Toshiko ; Teumer, Alexander ; Trompet, Stella ; Ulivi, Sheila ; Verweij, Niek ; Yin, Xiaoyan ; Arnar, David O. ; Asselbergs, Folkert W. ; Bader, Joel S. ; Barnard, John ; Bis, Josh ; Blankenberg, Stefan ; Boerwinkle, Eric ; Bradford, Yuki ; Buckley, Brendan M. ; Chung, Mina K. ; Crawford, Dana ; den Hoed, Marcel ; Denny, Josh C. ; Dominiczak, Anna F. ; Ehret, Georg B. ; Eijgelsheim, Mark ; Ellinor, Patrick T. ; Felix, Stephan B. ; Franco, Oscar H. ; Franke, Lude ; Harris, Tamara B. ; Holm, Hilma ; Ilaria, Gandin ; Iorio, Annamaria ; Kahonen, Mika ; Kolčić, Ivana ; Kors, Jan A. ; Lakatta, Edward G. ; Launer, Lenore J. ; Lin, Honghuang ; Lin, Henry J. ; Loos, Ruth J. F. ; Lubitz, Steven A. ; Macfarlane, Peter W. ; Magnani, Jared W. ; Leach, Irene Mateo ; Meitinger, Thomas ; Mitchell, Braxton D. ; Munzel, Thomas ; Papanicolaou, George J. ; Peters, Annette ; Pfeufer, Arne ; Pramstaller, Peter P. ; Raitakari, Olli T. ; Rotter, Jerome I. ; Rudan, Igor ; Samani, Nilesh J. ; Schlessinger, David ; Aldana, Claudia T. Silva ; Sinner, Moritz F. ; Smith, Jonathan D. ; Snieder, Harold ; Soliman, Elsayed Z. ; Spector, Timothy D. ; Stott, David J. ; Strauch, Konstantin ; Tarasov, Kirill V. ; Thorsteinsdottir, Unnur ; Uitterlinden, Andre G. ; Van Wagoner, David R. ; Voelker, Uwe ; Voelzke, Henry ; Waldenberger, Melanie ; Westra, Harm Jan ; Wild, Philipp S. ; Zeller, Tanja ; Alonso, Alvaro ; Avery, Christy L. ; Bandinelli, Stefania ; Benjamin, Emelia J. ; Cucca, Francesco ; Doerr, Marcus ; Ferrucci, Luigi ; Gasparini, Paolo ; Gudnason, Vilmundur ; Hayward, Caroline ; Heckbert, Susan R. ; Hicks, Andrew A. ; Jukema, J. Wouter ; Kaeaeb, Stefan ; Lehtimaki, Terho ; Liu, Yongmei ; Munroe, Patricia B. ; Parsa, Afshin ; Polašek, Ozren ; Psaty, Bruce M. ; Roden, Dan M. ; Schnabel, Renate B. ; Sinagra, Gianfranco ; Stefansson, Kari ; Stricker, Bruno H. ; van der Harst, Pim ; van Duijn, Cornelia M. ; Wilson, James F. ; Gharib, Sina A. ; de Bakker, Paul I. W. ; Isaacs, Aaron ; Arking, Dan E. ; Sotoodehnia, Nona

Izvornik
Nature communications (2041-1723) 9 (2018); 2904, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
COMMON VARIANTS ; HEART-RATE ; QRS DURATION ; CARDIAC CONDUCTION ; FIBRILLATION ; EPIDEMIOLOGY ; COHORTS ; RISK ; RARE ; SNPS

Sažetak
Electrocardiographic PR interval measures atrio- ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genomewide association study of over 92, 000 European-descent individuals identifies 44 PR interval loci (34 novel). Examination of these loci reveals known and previously not-yet-reported biological processes involved in cardiac atrial electrical activity. Genes in these loci are overrepresented in cardiac disease processes including heart block and atrial fibrillation. Variants in over half of the 44 loci were associated with atrial or blood transcript expression levels, or were in high linkage disequilibrium with missense variants. Six additional loci were identified either by meta- analysis of similar to 105, 000 African and European-descent individuals and/or by pleiotropic analyses combining PR interval with heart rate, QRS interval, and atrial fibrillation. These findings implicate developmental pathways, and identify transcription factors, ionchannel genes, and cell-junction/cell-signaling proteins in atrio-ventricular conduction, identifying potential targets for drug development.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ivana Kolčić (autor)

Avatar Url Ozren Polašek (autor)

Poveznice na cjeloviti tekst rada:

doi europepmc.org

Citiraj ovu publikaciju:

van Setten, Jessica; Brody, Jennifer A.; Jamshidi, Yalda; Swenson, Brenton R.; Butler, Anne M.; Campbell, Harry; Del Greco, Fabiola M.; Evans, Daniel S.; Gibson, Quince; Gudbjartsson, Daniel F. et al.
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity // Nature communications, 9 (2018), 2904, 11 doi:10.1038/s41467-018-04766-9 (međunarodna recenzija, članak, znanstveni)
Van Setten, J., Brody, J., Jamshidi, Y., Swenson, B., Butler, A., Campbell, H., Del Greco, F., Evans, D., Gibson, Q. & Gudbjartsson, D. (2018) PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. Nature communications, 9, 2904, 11 doi:10.1038/s41467-018-04766-9.
@article{article, author = {van Setten, Jessica and Brody, Jennifer A. and Jamshidi, Yalda and Swenson, Brenton R. and Butler, Anne M. and Campbell, Harry and Del Greco, Fabiola M. and Evans, Daniel S. and Gibson, Quince and Gudbjartsson, Daniel F. and Kerr, Kathleen F. and Krijthe, Bouwe P. and Lyytikainen, Leo-Pekka and Mueller, Christian and Mueller-Nurasyid, Martina and Nolte, Ilja M. and Padmanabhan, Sandosh and Ritchie, Marylyn D. and Robino, Antonietta and Smith, Albert V. and Steri, Maristella and Tanaka, Toshiko and Teumer, Alexander and Trompet, Stella and Ulivi, Sheila and Verweij, Niek and Yin, Xiaoyan and Arnar, David O. and Asselbergs, Folkert W. and Bader, Joel S. and Barnard, John and Bis, Josh and Blankenberg, Stefan and Boerwinkle, Eric and Bradford, Yuki and Buckley, Brendan M. and Chung, Mina K. and Crawford, Dana and den Hoed, Marcel and Denny, Josh C. and Dominiczak, Anna F. and Ehret, Georg B. and Eijgelsheim, Mark and Ellinor, Patrick T. and Felix, Stephan B. and Franco, Oscar H. and Franke, Lude and Harris, Tamara B. and Holm, Hilma and Ilaria, Gandin and Iorio, Annamaria and Kahonen, Mika and Kol\v{c}i\'{c}, Ivana and Kors, Jan A. and Lakatta, Edward G. and Launer, Lenore J. and Lin, Honghuang and Lin, Henry J. and Loos, Ruth J. F. and Lubitz, Steven A. and Macfarlane, Peter W. and Magnani, Jared W. and Leach, Irene Mateo and Meitinger, Thomas and Mitchell, Braxton D. and Munzel, Thomas and Papanicolaou, George J. and Peters, Annette and Pfeufer, Arne and Pramstaller, Peter P. and Raitakari, Olli T. and Rotter, Jerome I. and Rudan, Igor and Samani, Nilesh J. and Schlessinger, David and Aldana, Claudia T. Silva and Sinner, Moritz F. and Smith, Jonathan D. and Snieder, Harold and Soliman, Elsayed Z. and Spector, Timothy D. and Stott, David J. and Strauch, Konstantin and Tarasov, Kirill V. and Thorsteinsdottir, Unnur and Uitterlinden, Andre G. and Van Wagoner, David R. and Voelker, Uwe and Voelzke, Henry and Waldenberger, Melanie and Westra, Harm Jan and Wild, Philipp S. and Zeller, Tanja and Alonso, Alvaro and Avery, Christy L. and Bandinelli, Stefania and Benjamin, Emelia J. and Cucca, Francesco and Doerr, Marcus and Ferrucci, Luigi and Gasparini, Paolo and Gudnason, Vilmundur and Hayward, Caroline and Heckbert, Susan R. and Hicks, Andrew A. and Jukema, J. Wouter and Kaeaeb, Stefan and Lehtimaki, Terho and Liu, Yongmei and Munroe, Patricia B. and Parsa, Afshin and Pola\v{s}ek, Ozren and Psaty, Bruce M. and Roden, Dan M. and Schnabel, Renate B. and Sinagra, Gianfranco and Stefansson, Kari and Stricker, Bruno H. and van der Harst, Pim and van Duijn, Cornelia M. and Wilson, James F. and Gharib, Sina A. and de Bakker, Paul I. W. and Isaacs, Aaron and Arking, Dan E. and Sotoodehnia, Nona}, year = {2018}, pages = {11}, DOI = {10.1038/s41467-018-04766-9}, chapter = {2904}, keywords = {COMMON VARIANTS, HEART-RATE, QRS DURATION, CARDIAC CONDUCTION, FIBRILLATION, EPIDEMIOLOGY, COHORTS, RISK, RARE, SNPS}, journal = {Nature communications}, doi = {10.1038/s41467-018-04766-9}, volume = {9}, issn = {2041-1723}, title = {PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity}, keyword = {COMMON VARIANTS, HEART-RATE, QRS DURATION, CARDIAC CONDUCTION, FIBRILLATION, EPIDEMIOLOGY, COHORTS, RISK, RARE, SNPS}, chapternumber = {2904} }
@article{article, author = {van Setten, Jessica and Brody, Jennifer A. and Jamshidi, Yalda and Swenson, Brenton R. and Butler, Anne M. and Campbell, Harry and Del Greco, Fabiola M. and Evans, Daniel S. and Gibson, Quince and Gudbjartsson, Daniel F. and Kerr, Kathleen F. and Krijthe, Bouwe P. and Lyytikainen, Leo-Pekka and Mueller, Christian and Mueller-Nurasyid, Martina and Nolte, Ilja M. and Padmanabhan, Sandosh and Ritchie, Marylyn D. and Robino, Antonietta and Smith, Albert V. and Steri, Maristella and Tanaka, Toshiko and Teumer, Alexander and Trompet, Stella and Ulivi, Sheila and Verweij, Niek and Yin, Xiaoyan and Arnar, David O. and Asselbergs, Folkert W. and Bader, Joel S. and Barnard, John and Bis, Josh and Blankenberg, Stefan and Boerwinkle, Eric and Bradford, Yuki and Buckley, Brendan M. and Chung, Mina K. and Crawford, Dana and den Hoed, Marcel and Denny, Josh C. and Dominiczak, Anna F. and Ehret, Georg B. and Eijgelsheim, Mark and Ellinor, Patrick T. and Felix, Stephan B. and Franco, Oscar H. and Franke, Lude and Harris, Tamara B. and Holm, Hilma and Ilaria, Gandin and Iorio, Annamaria and Kahonen, Mika and Kol\v{c}i\'{c}, Ivana and Kors, Jan A. and Lakatta, Edward G. and Launer, Lenore J. and Lin, Honghuang and Lin, Henry J. and Loos, Ruth J. F. and Lubitz, Steven A. and Macfarlane, Peter W. and Magnani, Jared W. and Leach, Irene Mateo and Meitinger, Thomas and Mitchell, Braxton D. and Munzel, Thomas and Papanicolaou, George J. and Peters, Annette and Pfeufer, Arne and Pramstaller, Peter P. and Raitakari, Olli T. and Rotter, Jerome I. and Rudan, Igor and Samani, Nilesh J. and Schlessinger, David and Aldana, Claudia T. Silva and Sinner, Moritz F. and Smith, Jonathan D. and Snieder, Harold and Soliman, Elsayed Z. and Spector, Timothy D. and Stott, David J. and Strauch, Konstantin and Tarasov, Kirill V. and Thorsteinsdottir, Unnur and Uitterlinden, Andre G. and Van Wagoner, David R. and Voelker, Uwe and Voelzke, Henry and Waldenberger, Melanie and Westra, Harm Jan and Wild, Philipp S. and Zeller, Tanja and Alonso, Alvaro and Avery, Christy L. and Bandinelli, Stefania and Benjamin, Emelia J. and Cucca, Francesco and Doerr, Marcus and Ferrucci, Luigi and Gasparini, Paolo and Gudnason, Vilmundur and Hayward, Caroline and Heckbert, Susan R. and Hicks, Andrew A. and Jukema, J. Wouter and Kaeaeb, Stefan and Lehtimaki, Terho and Liu, Yongmei and Munroe, Patricia B. and Parsa, Afshin and Pola\v{s}ek, Ozren and Psaty, Bruce M. and Roden, Dan M. and Schnabel, Renate B. and Sinagra, Gianfranco and Stefansson, Kari and Stricker, Bruno H. and van der Harst, Pim and van Duijn, Cornelia M. and Wilson, James F. and Gharib, Sina A. and de Bakker, Paul I. W. and Isaacs, Aaron and Arking, Dan E. and Sotoodehnia, Nona}, year = {2018}, pages = {11}, DOI = {10.1038/s41467-018-04766-9}, chapter = {2904}, keywords = {COMMON VARIANTS, HEART-RATE, QRS DURATION, CARDIAC CONDUCTION, FIBRILLATION, EPIDEMIOLOGY, COHORTS, RISK, RARE, SNPS}, journal = {Nature communications}, doi = {10.1038/s41467-018-04766-9}, volume = {9}, issn = {2041-1723}, title = {PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity}, keyword = {COMMON VARIANTS, HEART-RATE, QRS DURATION, CARDIAC CONDUCTION, FIBRILLATION, EPIDEMIOLOGY, COHORTS, RISK, RARE, SNPS}, chapternumber = {2904} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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