Naslov
Multifunctional biomass-derived and N-doped carbon quantum dots – the versatile nanoparticles for ion sensing with potential biological and pharmacological activity
(Multifunctional biomass-derived and N-doped carbon quantum dots – the versatile nanoparticles for ion sensing with potential biological and pharmacological activity)

Autori
Šafranko, Silvija ; Jokić, Stela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
V. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science - Book of Abstracts / Varga, Patricia ; Szalai, Boglárka ; Uhljar, Luca Éva - Segedin, Mađarska, 2023, 30-30

Skup
V. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science

Mjesto i datum
Segedin, Mađarska, 18.01.2023. - 20.01.2023

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
carbon quantum dots ; biomass utilization ; sensors ; biomedical application

Sažetak
The aim of this study was to prepare, characterize and investigate the potential application of carbon quantum dots (CQD) derived from Citrus clementina peel. The prepared nanoparticles by hydrothermal synthesis using citric acid and amino acids of different complexity (Ala, Arg, Asn, Gln, Glu, Gly, His, Leu, Lys, Phe, Ser i Trp) represented model systems. The samples obtained from citric acid and amino acids Ala, Arg, His, Leu, Lys, and Trp showed great properties with calculated quantum yield (QY) from QY= 12.97% - 36.43% under investigated pH=7. Hence, these amino acids were selected for the biomass-derived CQD preparation from Citrus clementina peel. The results indicated the versatility among the prepared samples regarding optical, physical and chemical properties of nanoparticles, as well as on the biological activities, compared to the model systems. Furthermore, the best-performing samples from each series of synthesis were extensively studied regarding chemical (solubility, EDS), physical (AFM, FTIR, PXRD), optical (spectrofluorimetry, UV-Vis spectroscopy), biological and pharmacological properties. The biological activities of prepared samples were investigated by spectrophotometric methods of antiradical activity (DPPH method), inhibition of protein denaturation (bovine serum albumin and egg albumin), and biocompatibility/cytotoxicity was investigated on tumor cell lines (HeLa, NCI-H385, CaCo-2, D54). The samples were also utilized as fluorescent nanoprobe for selective and sensitive detection of Fe3+ ions and developed models were tested for the Fe3+ ion detection in real well- water samples. This research could be a good example of sustainable biomass waste utilization with potential for biomedical analysis and ion sensing applications.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Farmacija

POVEZANOST RADA