Naslov
First line H. pylori eradication therapy in Europe: results from 24,882 cases of the European registry on H. pylori management (HP-EUREG)

Autori
Nyssen O.P., Bordin D.S., Tepeš B., Perez Aisa M.Á., Caldas Álvarez M., Bujanda Fernández de Piérola L., Pabon Carrasco M., Castro Fernandez M., Lerang F., Leja M., Rokkas T., Kupcinskas L., Jonaitis L., Shvets O., Gasbarrini A., Axon A., Şimşek H., Buzás G.M., Machado J.C.L., Niv Y., Boyanova L., Rodrigo L., Perez-Lasala J., Goldis E.-A., Lamy V., Tonkić Ante, Przytulski K., Beglinger C., Venerito M., Bytzer P., Capelle L., Milivojević V., Veijola L., Molina Infante J., Vologzhanina L., Dino V., Fadeenko G., Ariño Pérez I., Fiorini G., Garre A., Keko-Huerga A., Heluwaert F., Garrido J., Fernandez Perez C., Puig I., Megraud F., O’Morain C., Gisbert J.P.

Kolaboracija
Hp-EuReg Investigators

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
United European Gastroenterology Journal 8(2020)S8 / - , 2020, 245-246

Skup
28th United European Gastroenterology Week

Mjesto i datum
Beč, Austrija; online, 11.10.2020. - 13.10.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Helicobacter pylori ; eradication therapy

Sažetak
Introduction: The best approach for Helicobacter pylori management remains unclear. An audit process is essential to ensure clinical practice is aligned with best standards of care.Aims & Methods: International multicentre prospective non-interventional registry starting in 2013 aimed to evaluate the decisions and outcomes in H. pylori management by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap up to April 2020. Variables included: demographics, previous eradication attempts, prescribed treatment, adverse events, and outcomes. Modified intention-to-treat (mITT) and per-protocol (PP) analyses were performed and data were subject to quality review to ensure information reliability.Results: In total 36, 319 patients from 29 European countries were evaluated and 24, 882 (70%) first-line empirical H. pylori treatments were included for analysis. Triple therapy with amoxicillin and clarithromycin was most commonly prescribed (40%), followed by concomitant treatment (19%) and bismuth quadruple (Pylera®) (10%) achieving 83%, 91% and 95% mITT eradication rate, respectively. Over 90% effectiveness was obtained only with 10 and 14-day bismuth quadruple or 14-day concomitant treatment (Table). Longer treatment duration, higher acid inhibition and compliance were associated with higher eradication rates.Conclusion: Management of H. pylori infection by European gastroenterologists is heterogeneous. Only quadruple therapies lasting at least ten days are able to achieve over 90% eradication rates.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA