Naslov
Comparison of the effectiveness of Helicobacter pylori eradication regimens between the elderly and non-elderly populations: data from the European registry on H. pylori management (HP- EUREG)

Autori
Jonaitis, P. ; Kupcinskas, J. ; Pérez-Aísa, Á. ; Vaira, D. ; Tepes, B. ; Bordin, D. ; Bujanda, L. ; Denkovski, M. ; Lanas, A. ; Leja, M. ; Babayeva, G. ; Lerang, F. ; Tonkić, Ante ; Nyssen, O. P. ; Moreira, L. ; Puig, I. ; Mégraud, F. ; O’Morain, C. ; Gisbert, J. P. ; Jonaitis, L.

Kolaboracija
Hp-EuReg Investigators

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
35th International Workshop on Helicobacter & Microbiota in Inflammation & Cancer / - , 2022, 19-21

Skup
International Workshop on Helicobacter and Microbiota in Inflammation and Cancer

Mjesto i datum
Glasgow, Ujedinjeno Kraljevstvo, 08.09.2022. - 10.09.2022

Vrsta sudjelovanja
Radionica

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Helicobacter pylori

Sažetak
Objective: It is important to assess the treatment efficacy and differences between the elderly and non-elderly populations. The aim of the study is to compare the efficacy of first- and second-line H. pylori eradication regimens between the elderly and non-elderly. Materials and Methods: European multicenter registry of H. pylori infection management (Hp- EuReg) collecting data until 2022. Subjects were divided into the non-elderly (18-59 years) and elderly (≥60 years) groups. Per- Protocol (PP) and modified Intention-To-Treat (mITT) analyses were performed. Results: Overall 34, 994 (71%) non-elderly and 14, 467 (29%) elderly patients were included. In first- and second-line treatment, quadruple therapies were prescribed in 45% and 51% of the cases, respectively, whereas triple therapies in 44% in both lines. The overall first-line treatment effectiveness was 89% by PP and 88% by mITT in the non-elderly, and 90% by PP and 89% by mITT in the elderly (p<0.05). The overall second- line treatment effectiveness was 84% both by PP and mITT analyses in both groups (p>0.05). The main 6 regimens by line and their effectiveness are reported in Table 1. The elderly group was associated with significantly higher overall mITT eradication rate in the first-line treatment. Conclusions: The overall effectiveness and the effectiveness of most frequent first- and second- line H. pylori eradication regimens in Europe is suboptimal (<90%). Optimal effectiveness (>90%) was achieved with quadruple therapies. No clinically relevant differences between elderly and non-elderly patients were observed.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA