Naslov
Role of compliance in Helicobacter pylori treatments: results from the European registry on H. pylori management (HP- EUREG)

Autori
Huguet, J. M. ; Ferrer-Barceló, L. ; Suárez, P. ; Tepes, B. ; Bordin, D. ; Leja, M. ; Babayeva, G. ; Lerang, F. ; Tonkić, Ante ; Simsek, H. ; Kunovský, L. ; Gasbarrini, A. ; Buzas, G. M. ; Phull, P. ; Venerito, M. ; Puig, I. ; Nyssen, O. P. ; Mégraud, F. ; O’Morain, C. ; Gisbert, J. P.

Kolaboracija
Hp-EuReg Investigators

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
35th International Workshop on Helicobacter & Microbiota in Inflammation & Cancer / - , 2022, 39-40

Skup
International Workshop on Helicobacter and Microbiota in Inflammation and Cancer

Mjesto i datum
Glasgow, Ujedinjeno Kraljevstvo, 08.09.2022. - 10.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Helicobacter pylori

Sažetak
Objective: The adherence to Helicobacter pylori eradication treatment is a cornerstone for achieving an adequate treatment efficacy. The objective of the study was to determine which factors could influence on the compliance of treatments. Materials and Methods: Systematic prospective non- interventional registry (Hp- EuReg) of the clinical practice of European gastroenterologists. Compliance was adequate: >90% drug intake. Data collected until September 2021 at AEG-REDCap e- CRFand was subject to quality control. Modified intention-to-treat (mITT) analyses were performed. The multivariate analysis evaluated the factors associated with the effectiveness of the treatments and the compliance. Results: Of the 38, 698 records, 646 (1.7%) did not have adequate compliance. There was a higher non- compliance rate in patients prescribed with longer therapies (10-, 14-days), rescue treatment, with uninvestigated/functional dyspepsia, and reporting adverse events. Non- adherence was lower in first- line as compared to rescue treatment (1.5% vs. 2.2% ; p<0, 001). Non- adherence in the three most frequent first-line treatments was significantly different: 1.1% with PPI-clarithromycin- amoxicillin ; 2.3% with PPI- clarithromycin- amoxicillin-metronidazole ; and 1.8% with bismuth quadruple therapy ; and their effectiveness was significantly higher in compliant vs. non- compliant patients: 86% vs. 44% ; 90% vs. 71% and 93% vs. 64%, respectively (p<0.001). In the multivariate analysis, the variable which was most significantly associated with higher effectiveness was the adequate compliance with the treatment (OR: 6.3 ; 95%CI: 5.2-7.7 ; p<0.001). Conclusions: Compliance with H. pylori eradication treatment is very high. Factors associated with poor compliance: uninvestigated/functional dyspepsia, rescue- treatment, prolonged treatment regimens, the presence of adverse events, and the use of sequential and concomitant treatment. Adequate treatment compliance was the variable most closely associated with an eradication success.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA