Naslov
Central and peripheral testosterone effects in men with heart failure: an approach for cardiovascular research.

Autori
Bušić, Željko ; Čulić, Viktor

Izvornik
World journal of cardiology (1949-8462) 7 (2015), 9; 504-510

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, uvodnik, stručni

Ključne riječi
Cardiomyocytes ; Electrophysiology ; Exercise ; Heart failure ; Testosterone ; Vasodilation

Sažetak
Heart failure (HF) is a syndrome recognized as a health problem worldwide. Despite advances in treatment, patients with HF still have increased morbidity and mortality. Testosterone is one of the most researched hormones in the course of HF. Growing interest regarding the effect of testosterone, on a variety of body systems, has increased the knowledge about its mechanisms of action. The terms central and peripheral effects are used to distinguish the effects of testosterone on cardiac and extracardiac structures. Central effects include influences on cardiomyocytes and electrophysiology. Peripheral effects include influences on blood vessels, baroreceptor reactivity, skeletal muscles and erythropoesis. Current knowledge about peripheral effects of testosterone may explain much about beneficiary effects in the pathophysiology of HF syndrome. However, central, i.e., cardiac effects of testosterone are to be further explored.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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