Naslov
Kontrolirano kliničko ispitivanje metilprednisolona u bolesnika sa kolestatskim oblikom alkoholne ciroze jetre
(A controlled clinical trial of methylprednisolone in patients with the cholestatic form of alcoholic liver cirrhosis)

Autori
Hozo Izet ; Miše Stjepan ; Rumboldt Zvonko ; Bagatin Jugoslav ; Tonkić Ante

Izvornik
Medicinski arhiv (0350-199X) 50 (1996), 3-4; 81-83

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Adult ; Cholestasis ; Double-Blind Method ; Female ; Glucocorticoids ; Humans ; Liver Cirrhosis, Alcoholic ; Male ; Methylprednisolone ; Prospective Studies

Sažetak
Fourty patients with alcoholic liver cirrhosis and refractory hyperbilirubinaemia were included in a prospective, double blind, comparative trial. Twenty of them were randomized to methylprednisolone (1 mg/kg/day i.m. over 3 days), and 20 to placebo (saline) of identical shape. In the active group a significant decrease in the bilirubin level (from 248 to 191 mumol/l, a drop by 23% ; p < 0.05) was observed, which was not the case in the control group (from 292 to 300 mumol/l, an increase by 2.7% ; p > 0.05). A decrease in the alkaline phosphatase activity was observed in both groups (by 11% in the active and by 20% in the control group: p < 0.05) while the encephalopathic indices did not improve in either. It is concluded that a short course of corticosteroid could speed-up the hospital stay and possibly slow down the progression of alcoholic cirrhosis.

Izvorni jezik
Hrvatski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA