Naslov
Thermotropic properties of unilamellar and multilamellar DPPS bilayers

Autori
Pašalić, Lea ; Bakarić, Danijela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
V. simpozij supramolekulske kemije : knjiga sažetaka = Supramolecular Chemistry 2022 : Book of Abstract / Frkanec, Leo ; Namjesnik, Danijel ; Tomišić, Vladislav - Zagreb : Institut Ruđer Bošković, 2022, 32-32

Skup
V. simpozij supramolekulske kemije: Supramolecular Chemistry

Mjesto i datum
Zagreb, Hrvatska, 08.12.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
biomembrane ; multilamelarni liposomi ; unilamelarni liposomi ; spektroskopija ; kalorimetrija
(Biomembranes ; multilamellar liposomes ; unilamellar liposomes ; spectroscopy ; calorimetry)

Sažetak
Biological membranes have a complex composition and consist of hundreds of different lipids, asymmetrically distributed between the inner and outer bilayer leaflets. A lipid of special interest in eukaryotic membranes is the negatively charged phosphatidylserine (PS), located on cytosolic leaflet.1 One of its primary functions seems to be to impart a negative charge to the inner surface of the membrane lipid bilayer which is required for the binding and activation of various peripheral membrane proteins.2 Liposomes (lipid vesicles) are suspensions of membrane lipids in which a lipid bilayer surrounds an aqueous lumen and they serve as model system for cell membrane.3 Commonly used phosphatidiylserine-constituted lipid membranes are multilamellar liposomes (MLV) while unilamellar liposomes (LUV) are more realistic model membrane system, not researched enough because of instability. The liposomes prepared in this experiment form as MLV and LUV. In order to examine their thermotropic properties we preformed calorimetric and spectroscopic study of both, MLV and LUV, constituted from 2-dipalmitoyl-sn- glycero-3phosphatidylserine (DPPS).

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA