Naslov
Lipase-Catalyzed Desymmetrization of Prochiral Ferrocene Diols

Autori
Đaković, Senka ; Lapić, Jasmina ; Rapić, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XVIII. hrvatski skup kemičara i kemijskih inženjera : Sažeci = Abstracts / Zrnčević, Stanka - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Hrvatsko kemijsko drustvo ; Hinus, 2003, 63-63

ISBN
953-6894-08-4

Skup
Hrvatski skup kemičara i kemijskih inženjera (18 ; 2003)

Mjesto i datum
Zagreb, Hrvatska, 16.02.2003. - 19.02.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
lipase-catalyzed; ferrocene; diol

Sažetak
Prochiral diols (meso-compounds or molecules possesing pseudo-asymmetric centers) are very useful synthetic intermediates because the maximum feasible yield upon their enzymatic transformation is not limited to 50 %, as happens when resolving racemic mixtures. Different prochiral ferrocene diols (1, 4 and 7), as well as the corresponding monoacetates (2, 5 and 8) and diacetates (3, 6 and 9) were prepared according to the procedure described in our previous paper [1]. The carbinols prepared underwent stereoselective acylation in benzene solution at 27 ^oC by the action of vinyl acetate as acyl donor in the presence of various lipases. The course of these conversions was followed by the HPLC technique and the optical purity of the compounds prepared was examined on a chiral column Chiracel OD-H. In these biotransformations e.e. ranging from 87 to 90 % were reached. The absolute configuration of the monoacetates obtained was determined by CD-spectroscopy.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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