Pregled bibliografske jedinice broj: 1241717
Antiplasmodial activity of harmirins – novel harmine-coumarin hybrids
Antiplasmodial activity of harmirins – novel harmine-coumarin hybrids // Macedonian Pharmaceutical Bulletin 68 (Suppl 1) / Glavas Dodov, Marija (ur.).
Skopje: Macedonian Pharmaceutical Association, 2022. str. 407-408 doi:10.33320/maced.pharm.bull.2022.68.03.196 (poster, međunarodna recenzija, kratko priopćenje, znanstveni)
CROSBI ID: 1241717 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Antiplasmodial activity of harmirins – novel
harmine-coumarin hybrids
Autori
Pavić, Kristina ; Rajić, Zrinka ; Pessanha de Carvalho, Lais ; Held, Jana
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, kratko priopćenje, znanstveni
Izvornik
Macedonian Pharmaceutical Bulletin 68 (Suppl 1)
/ Glavas Dodov, Marija - Skopje : Macedonian Pharmaceutical Association, 2022, 407-408
Skup
7th Congress of Pharmacy in North Macedonia with international participation
Mjesto i datum
Ohrid, Sjeverna Makedonija, 05.10.2022. - 09.10.2022
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
harmine ; coumarin ; malaria ; Plasmodium
Sažetak
Harmirins are hybrid compounds comprising both harmine and coumarin pharmacophores linked by 1, 2, 3-triazole. We have evaluated in vitro antiplasmodial activity against the erythrocytic stage of P. falciparum of five series of harmirins. Compound 12b showed the highest activity against the tested P. falciparum strains and the lowest cytotoxicity against non-cancer cell line Hek293.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
POVEZANOST RADA
Projekti:
UIP-2017-05-5160 - Derivati harmina kao potencijalni antimalarici (CLICKforMALARIA) (Rajić Džolić, Zrinka, HRZZ - 2017-05) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb
