Naslov
Serotonin 1B (5HT-1B) receptor polymorphism (G861C) in suicide victims: association studies in German and Slavic population

Autori
Štefulj, Jasminka ; Büttner, Andreas ; Škavić, Josip ; Zill, Peter ; Balija, Melita ; Eisenmenger, Wolfgang ; Bondy, Brigitta ; Jernej, Branimir

Izvornik
American Journal of Medical Genetics B (1552-4841) 127B (2004), 1; 48-50

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
5HT-1B receptor gene; suicidal behaviour; ethnicity

Sažetak
Serotonergic dysfunction is believed to be involved in the susceptibility to suicide due to functional alternations in the serotonin-related genes. Serotonin 5HT-1B receptor mediates aggressive behaviour in mice models and was proposed to be involved in the control of aggression and impulsivity in humans. In this work we have investigated the association of G861C polymorphism of the 5HT-1B receptor gene with suicide commitment. Study was based on two independent samples, one of German (245 suicide victims versus 248 controls) and the other of Slavic/Croatian (118 suicide victims versus 192 controls) ethnicity. No significant differences in allele or genotype frequencies between victims and controls were demonstrated either in German or Croatian sample. There were no differences in allele frequencies between German and Croatian population, and the combined sample, having high statistical power, also did not demonstrate significant differences between victims and controls. Results provide clear evidence that the investigated 5HT-1B receptor gene variants are not implicated in the susceptibility to suicide.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA