Naslov
Low iodine diet in patients with differentiated thyroid cancer

Autori
Dobrenić, Margareta

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
30th Annual Congress of the European Association of Nuclear Medicine - EANM`17

Mjesto i datum
Beč, Austrija, 21.10.2017. - 25.10.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
low iodine diet, thyroid cancer

Sažetak
Introduction: Low iodine diet, or restricted intake of iodine-rich food is recommended to all patients with differentiated thyroid cancer prior to I-131 administration. The majority of guidelines recommend low iodine diet prior to I- 131 application, but its duration and effectiveness, as well as target urinary iodine concentration are not established. The aim of this study is to evaluate the influence of low iodine diet on total body iodine content and on radioiodine avidity of tumor cells in patients with differentiated thyroid cancer and biochemically persistent disease. Materials and Methods: A total of 77 patients with differentiated thyroid cancer, thyroglobulin > 2 ng/mL, and negative I-131 whole body scan underwent low iodine diet. Each patient underwent a two-week low iodine diet, with the aim to achieve moderate iodine deficiency. Those who accomplished only mild iodine deficiency after a two-week low iodine diet received a recommendation to follow the diet for a further week (three-week diet) before the next I-131 administration.To evaluate the effectiveness of low iodine diet, iodine concentration in morning urine samples was measured in each patient, a day before starting the diet and on the 15th (21st) day after starting it.For the impact assessment of low iodine diet on radioiodine tissue avidity, whole body radioiodine scans before and after low iodine diet were visually compared. Results: Following self-managed low iodine diet, all patients were able to significantly reduce their total body iodine content by 50% (range 18-64%). A total of 68 patients (88%) accomplished mild iodine deficiency and 9 patients (12%) achieved the targeted moderate iodine deficiency state. There was no significant difference in the reduction of total body iodine content between groups that underwent two and three-week iodine diets. Furthermore, there was no significant impact of reduced total body iodine content on radioiodine avidity of tumor cells in patients who underwent low iodine diet. Discussion: Low iodine diet is an effective way to reduce total body iodine content in patients with differentiated thyroid cancer prior to I-131 administration. However, in patients with biochemically persistent malignant disease, neither mild nor moderate iodine deficiency had an effect on radioiodine avidity of tumor cells

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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