Naslov
Glycerol and natural deep eutectic solvents xxtraction for preparation of luteolin-rich Jasione montana extracts with cosmeceutical activity

Autori
Juszczak, Aleksandra Maria ; Marijan, Marijan ; Jakupović, Lejsa ; Tomczykowa, Monika ; Tomczyk Michal, Zovko Končić, Marijana

Izvornik
Metabolites (2218-1989) 13 (2023), 1; 32, 20

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Jasione montana ; Campanulaceae ; antioxidant ; collagenase ; elastase ; hyaluronidase ; luteolin ; natural deep eutectic solvents

Sažetak
Jasione montana is a plant from the family Campanulaceae rich in phenols with healthbeneficial properties such as luteolin (LUT) derivatives. In this work, a glycerol-based ultrasoundassisted extraction method was developed and optimized for in total phenol (TP) and LUT content, as well as antiradical activity (RSA). The best conditions (glycerol content, temperature, plant material weight, and ultrasonication power) for the preparation of J. montana extracts richest in TP (OPT-TP), LUT (OPT- LUT), and having the best RSA (OPT-RSA) were determined. Furthermore, numerous natural deep eutectic solvents (NADES), containing proline, glycerol, betaine, urea, and glucose were prepared and used for the extraction of J. montana. Contents of TP, LUT, and RSA in the prepared extracts were established. Antioxidant and cosmeceutical activity of the prepared extracts was tested. The OPT-TP, OPT-LUT, and OPT-RSA, as well as the most efficient NADES-based extract, PG-50-TP, were excellent antioxidants and Fe2+ ion chelators. In addition, they were potent inhibitors of collagenase and hyaluronidase, as well as good significant anti-elastase and - lipoxygenase activity. The observed antioxidant- and enzyme-inhibiting activity of J. montana extracts prepared using environmentally friendly methods and non-toxic solvents makes them promising ingredients of cosmeceutical products.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA