Naslov
Changes in Ghrelin and PYY and weight status in children after a one year follow up

Autori
Petričević, Nina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Congress on Obesity (ECO2018) 25th Congress, Vienna, May 2018: Abstracts / - , 2018, 104-104

Skup
European Congress on Obesity (ECO2018) 25th Congress, Vienna, May 2018: Abstracts

Mjesto i datum
Vienna, Austria, 23-26.05.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
children, ghrelin, PYY

Sažetak
Introduction: Ghrelin is a hunger hormone, produced mainly by the stomach and is usually lower in obesity. PYY is a satiety hormone, secreted mainly in small intestine and research is not that conclusive about its levels in obesity. Aim was to investigate ghrelin and PYY levels, their association with weight status, anthropometric measures, obesity, puberty and living habits at the baseline and after a one year follow up. Methods: Prospective study in free-living conditions with one year follow up. Sample of 100 children (56 female, mean age 13.3 ± 0.33 years) was selected by a randomized procedure of children born on the same year from the area of one school health service in Zagreb, Croatia. Cohort of 83 children (45 female, mean age 14.4 ± 0.28 years) completed assessment at baseline and at one-year follow up. methods on both occasions included physical examination with anthropometric measures done by school doctors, fasting ghrelin and PYY hormone analysis and parents and children’s questionnaire on living habits. Data were analysed by multivariate logistic regression models by gender. Results: At the baseline, 76% of children were normal weight, 19% were overweight and 4% were obese, using the WHO charts. Ghrelin was negatively correlated with BMI z-score (r = -0.25 ; p = 0.012). There was no correlation between PYY and BMI z-score. After a one year follow up, there was significant decrease in ghrelin levels (T = 4.68 ; p < 0.001), however there was no change in PYY levels after a follow up (T = 1.18 ; p = 0.239). After a follow up there was no change in nutritional status among children, but there was a significant change in puberty status (p < 0.001). The greatest decrease of ghrelin level after a follow up was in children with lower puberty stage at the baseline ( F = 3.142 ; p = 0.018). Ghrelin correlates negatively with puberty. PYY levels are not correlated with weight status, anthropometric measurements or puberty. Significant predictors for ghrelin change are change of height and hip circumference and BMI z-score change (R = 0, 614 ; R2 = 0, 376 ; Adjusted R2 = 0, 317 ; F = 6, 297 ; p < 0, 001). Conclusion: Ghrelin is lower among overweight and obese children and PYY does not correlate with weight status. After a one year follow up in free living conditions, there is significant change in ghrelin levels (significantly lower) and no change in PYY levels.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA