Naslov
New and Emerging Targeted Therapies for Hidradenitis Suppurativa

Autori
Markota Čagalj, Adela ; Marinović, Branka ; Bukvić Mokos, Zrinka

Izvornik
International journal of molecular sciences (1422-0067) 23 (2022), 7; 3753, 32

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
hidradenitis suppurativa ; biologics ; TNF-alpha inhibitors ; IL-17 inhibitors ; IL-1 inhibitor

Sažetak
Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin disease deriving from the hair follicles. The formation of inflammatory nodules, abscesses, fistulas, and sinus tracts is characterized by a large inflow of key pro- inflammatory mediators, such as IFN-gamma, TNF- alpha, IL-1, IL-17, and IL-12/23. Adalimumab is currently the only Food and Drug Administration (FDA)-and European Medicines Agency (EMA)-approved biologic therapy for moderate to severe HS in adults and adolescents. However, the long-term effectiveness of this TNF-alpha inhibitor in HS patients has shown to be highly variable. This review aims to review the evidence for emerging therapies that target the main pro-inflammatory cytokines in HS pathogenesis. A review of the literature was conducted, using the PubMed and Google Scholar repositories, as well as Clinicaltrials.gov . Presently, the most promising biologics in phase III trials are anti-IL-17 antibodies, secukinumab, and bimekizumab. Furthermore, an anti-IL-1 biologic, bermekimab, is currently in phase II trials, and shows encouraging results. Overall, the clinical efficacies of all new targeted therapies published up to this point are limited. More studies need to be performed to clarify the precise molecular pathology, and assess the efficacy of biological therapies for HS.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA