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Pregled bibliografske jedinice broj: 1238846

PD-1 and PD-L1 expression predict regression and prognosis following neoadjuvant radiochemotherapy of oesophageal adenocarcinoma

Göbel, Holger H.; Distel, Luitpold V. R.; Aigner, Thomas; Büttner-Herold, Maike J.; Grabenbauer, Gerhard G.
PD-1 and PD-L1 expression predict regression and prognosis following neoadjuvant radiochemotherapy of oesophageal adenocarcinoma // Clinical and Translational Radiation Oncology, 34 (2022), 90-98 doi:10.1016/j.ctro.2022.04.001 (međunarodna recenzija, članak, znanstveni)

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Naslov
PD-1 and PD-L1 expression predict regression and prognosis following neoadjuvant radiochemotherapy of oesophageal adenocarcinoma

Autori
Göbel, Holger H. ; Distel, Luitpold V. R. ; Aigner, Thomas ; Büttner-Herold, Maike J. ; Grabenbauer, Gerhard G.

Izvornik
Clinical and Translational Radiation Oncology (2405-6308) 34 (2022); 90-98

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Esophageal adenocarcinoma ; CD8+ ; PD-1 ; PD-L1 ; Radiochemotherapy

Sažetak
Background and purpose: PD-1 and PD-L1 are involved in anticancer immunosurveillance, and their expression may be predictive for therapeutic effectiveness of specific antibodies. Their influence on response to neoadjuvant radiochemotherapy (RCT) and prognosis in patients with oesophageal adenocarcinoma (OAC) remains to be defined. Materials and methods: Between 10/2004 and 06/2018, complete pre-RCT biopsy-specimens were available from 76 patients with locally advanced, non-metastatic OAC scheduled for trimodality therapy. We evaluated intraand peritumoural expression of CD8, PD-1 and PD-L1 in pre-treatment specimens to determine their influence on tumour regression grade and survival. PD-1 and PD-L1 expression were considered positive (+) if >= 1% of all cells were stained positive, otherwise negative (-) ; densities of CD8+ cells were categorized as being high (Hi) or low (Lo) according to the median. Results: A negative PD-L1 expression in peritumoural cells predicted a poor tumour regression (RD 0.24 [95% CI 0.03-0.44], p = 0.023). A positive PD-1 expression in intra- as well as peritumoural cells was identified as an unfavourable prognostic factor (HR 0.52 [95% CI 0.29-0.93], p = 0.028 ; HR 0.50 [0.25-0.99], p = 0.047, respectively). With respect to CD8+ infiltration, positive PD-1 and PD-L1 expressions attenuated its favourable prognostic effect in intratumoural area (LoCD8/PD1 + vs. HiCD8/PD1-: HR 0.25 [0.09-0.69], p = 0.007 ; LoCD8/ PDL1+ vs. HiCD8/PDL1-: HR 0.32 [0.12-0.89], p = 0.028) and were associated with negative outcome when seen in peritumoural area (HiCD8/PD1+ vs. LoCD8/PD1-: HR 0.29 [0.11-0.74], p = 0.010) ; HiCD8/PDL1+ vs. LoCD8/PDL1-: HR 0.33 [0.12-0.90], p = 0.031). Conclusions: PD-1 and PD-L1 expression were identified to be of predictive and prognostic value in patients with OAC, particularly when considering CD8+ infiltration. Further validation by a large size dataset is required.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Poveznice na cjeloviti tekst rada:

doi www.ctro.science

Citiraj ovu publikaciju:

Göbel, Holger H.; Distel, Luitpold V. R.; Aigner, Thomas; Büttner-Herold, Maike J.; Grabenbauer, Gerhard G.
PD-1 and PD-L1 expression predict regression and prognosis following neoadjuvant radiochemotherapy of oesophageal adenocarcinoma // Clinical and Translational Radiation Oncology, 34 (2022), 90-98 doi:10.1016/j.ctro.2022.04.001 (međunarodna recenzija, članak, znanstveni)
Göbel, H., Distel, L., Aigner, T., Büttner-Herold, M. & Grabenbauer, G. (2022) PD-1 and PD-L1 expression predict regression and prognosis following neoadjuvant radiochemotherapy of oesophageal adenocarcinoma. Clinical and Translational Radiation Oncology, 34, 90-98 doi:10.1016/j.ctro.2022.04.001.
@article{article, author = {G\"{o}bel, Holger H. and Distel, Luitpold V. R. and Aigner, Thomas and B\"{u}ttner-Herold, Maike J. and Grabenbauer, Gerhard G.}, year = {2022}, pages = {90-98}, DOI = {10.1016/j.ctro.2022.04.001}, keywords = {Esophageal adenocarcinoma, CD8+, PD-1, PD-L1, Radiochemotherapy}, journal = {Clinical and Translational Radiation Oncology}, doi = {10.1016/j.ctro.2022.04.001}, volume = {34}, issn = {2405-6308}, title = {PD-1 and PD-L1 expression predict regression and prognosis following neoadjuvant radiochemotherapy of oesophageal adenocarcinoma}, keyword = {Esophageal adenocarcinoma, CD8+, PD-1, PD-L1, Radiochemotherapy} }
@article{article, author = {G\"{o}bel, Holger H. and Distel, Luitpold V. R. and Aigner, Thomas and B\"{u}ttner-Herold, Maike J. and Grabenbauer, Gerhard G.}, year = {2022}, pages = {90-98}, DOI = {10.1016/j.ctro.2022.04.001}, keywords = {Esophageal adenocarcinoma, CD8+, PD-1, PD-L1, Radiochemotherapy}, journal = {Clinical and Translational Radiation Oncology}, doi = {10.1016/j.ctro.2022.04.001}, volume = {34}, issn = {2405-6308}, title = {PD-1 and PD-L1 expression predict regression and prognosis following neoadjuvant radiochemotherapy of oesophageal adenocarcinoma}, keyword = {Esophageal adenocarcinoma, CD8+, PD-1, PD-L1, Radiochemotherapy} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Emerging Sources Citation Index (ESCI)
  • Scopus

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