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Pregled bibliografske jedinice broj: 1238598

Impact of the pre-examination phase on multicenter metabolomic studies

Ghini, Veronica; Abuja, Peter M.; Polašek, Ozren; Kozera, Lukasz; Laiho, Paivi; Anton, Gabriele; Zins, Marie; Klovins, Janis; Metspalu, Andres; Wichmann, H-Erich et al.
Impact of the pre-examination phase on multicenter metabolomic studies // New Biotechnology, 68 (2022), 37-47 doi:10.1016/j.nbt.2022.01.006 (međunarodna recenzija, članak, znanstveni)

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Naslov
Impact of the pre-examination phase on multicenter metabolomic studies

Autori
Ghini, Veronica ; Abuja, Peter M. ; Polašek, Ozren ; Kozera, Lukasz ; Laiho, Paivi ; Anton, Gabriele ; Zins, Marie ; Klovins, Janis ; Metspalu, Andres ; Wichmann, H-Erich ; Gieger, Christian ; Luchinat, Claudio ; Zatloukal, Kurt ; Turano, Paola

Izvornik
New Biotechnology (1871-6784) 68 (2022); 37-47

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Metabolomics ; Pre-analytical procedures ; NMR ; Biobanks

Sažetak
The development of metabolomics in clinical applications has been limited by the lack of validation in large multicenter studies. Large population cohorts and their biobanks are a valuable resource for acquiring insights into molecular disease mechanisms. Nevertheless, most of their collections are not tailored for metabolomics and have been created without specific attention to the pre-analytical requirements for high-quality metabolome assessment. Thus, comparing samples obtained by different pre-analytical procedures remains a major challenge. Here, H-1 NMR-based analyses are used to demonstrate how human serum and plasma samples collected with different operating procedures within several large European cohort studies from the Biobanking and Biomolecular Resources Infrastructure - Large Prospective Cohorts (BBMRI-LPC) consortium can be easily revealed by supervised multivariate statistical analyses at the initial stages of the process, to avoid biases in the downstream analysis. The inter-biobank differences are discussed in terms of deviations from the validated CEN/TS 16945:2016 / ISO 23118:2021 norms. It clearly emerges that biobanks must adhere to the evidence-based guidelines in order to support wider-scale application of metabolomics in biomedicine, and that NMR spectroscopy is informative in comparing the quality of different sample sources in multi cohort/center studies.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Poveznice na cjeloviti tekst rada:

doi reader.elsevier.com

Citiraj ovu publikaciju:

Ghini, Veronica; Abuja, Peter M.; Polašek, Ozren; Kozera, Lukasz; Laiho, Paivi; Anton, Gabriele; Zins, Marie; Klovins, Janis; Metspalu, Andres; Wichmann, H-Erich et al.
Impact of the pre-examination phase on multicenter metabolomic studies // New Biotechnology, 68 (2022), 37-47 doi:10.1016/j.nbt.2022.01.006 (međunarodna recenzija, članak, znanstveni)
Ghini, V., Abuja, P., Polašek, O., Kozera, L., Laiho, P., Anton, G., Zins, M., Klovins, J., Metspalu, A. & Wichmann, H. (2022) Impact of the pre-examination phase on multicenter metabolomic studies. New Biotechnology, 68, 37-47 doi:10.1016/j.nbt.2022.01.006.
@article{article, author = {Ghini, Veronica and Abuja, Peter M. and Pola\v{s}ek, Ozren and Kozera, Lukasz and Laiho, Paivi and Anton, Gabriele and Zins, Marie and Klovins, Janis and Metspalu, Andres and Wichmann, H-Erich and Gieger, Christian and Luchinat, Claudio and Zatloukal, Kurt and Turano, Paola}, year = {2022}, pages = {37-47}, DOI = {10.1016/j.nbt.2022.01.006}, keywords = {Metabolomics, Pre-analytical procedures, NMR, Biobanks}, journal = {New Biotechnology}, doi = {10.1016/j.nbt.2022.01.006}, volume = {68}, issn = {1871-6784}, title = {Impact of the pre-examination phase on multicenter metabolomic studies}, keyword = {Metabolomics, Pre-analytical procedures, NMR, Biobanks} }
@article{article, author = {Ghini, Veronica and Abuja, Peter M. and Pola\v{s}ek, Ozren and Kozera, Lukasz and Laiho, Paivi and Anton, Gabriele and Zins, Marie and Klovins, Janis and Metspalu, Andres and Wichmann, H-Erich and Gieger, Christian and Luchinat, Claudio and Zatloukal, Kurt and Turano, Paola}, year = {2022}, pages = {37-47}, DOI = {10.1016/j.nbt.2022.01.006}, keywords = {Metabolomics, Pre-analytical procedures, NMR, Biobanks}, journal = {New Biotechnology}, doi = {10.1016/j.nbt.2022.01.006}, volume = {68}, issn = {1871-6784}, title = {Impact of the pre-examination phase on multicenter metabolomic studies}, keyword = {Metabolomics, Pre-analytical procedures, NMR, Biobanks} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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