Naslov
Assessement of cytotoxic and genotoxic effect of whitening toothpastes in buccal mucosal cells

Autori
Vladislavić, Nada Zorica ; Franić, Ivana ; Gavić, Lidia ; Tadin, Antonija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
6th International Congress of the Department of Endodontics and Restorative Dentistry, School of Dental Medicine, University of Zagreb in co- organization with the Croatian Society for Minimum Intervention Dentistry CMA: „Science and Clinical Work Sinergy“ / Jukić Krmek, Silvana ; Miletić, Ivana - Zagreb : Stomatolški fakultet Sveučilišta u Zagrebu, 2022, 441-446

Skup
VI. kongres s Zavoda za endodonciju i restaurativnu stomatologiju Stomatološkog fakulteta Sveučilišta u Zagrebu = 6th International Congress of the Department of Endodontics and Restorative Dentistry, School of Dental Medicine, University of Zagreb

Mjesto i datum
Zagreb, Hrvatska, 21.10.2022. - 22.10.2022

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cytotoxicity ; genotoxicity ; buccal mucosal cells ; micronucleus assay ; whitening toothpastes

Sažetak
Aim: To assess the cytotoxic and genotoxic effects of commercially available whitening toothpastes with different ingredients using a buccal micronucleus cytome assay. Materials and methods: This prospective, parallel randomized controlled clinical trial was conducted using a buccal micronucleus cytome assay (BMCyt assay). 198 participants were randomly divided into ten groups based on used toothpaste (9 whitening toothpastes and 1 conventional toothpaste). Buccal mucosal cell samples were taken at baseline (T0), 30 and 60 days from the beginning of treatment (T1, T2) and 30 days after using the tested toothpaste (T3). Results: Genotoxic parameters didn’t show biologically significant changes within testing whitening toothpastes. Cytotoxic parameters (number of cells with karyorrhexis and condensed chromatin) showed statistically significant increase (p<0.05) at T1 and T2 compared to baseline for three peroxide containing toothpastes. Conclusion: It can be concluded that the usage of toothpastes with whitening ingredients doesn’t lead to cytogenetic damage of buccal mucosa cells. In clinical conditions, the obtained changes can’t be considered as significant.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

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