Naslov
Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance

Autori
Munk P ; Brinch C ; Duus Møller F ; Petersen TN ; Hendriksen RS ; Seyfarth AM ; Kjeldgaard JS ; Svendsen CA ; van Bunnik B ; Berglund F ; (Global Sewage Surveillance Consortium: Larsson DGJ, Koopmans M, Woolhouse M, Bego A, Power P, Rees C, Lambrinidis D, Neilson EHJ, Gibb K, Coventry K, Collignon P, Cassar S, Allerberger F, Begum A, Hossain ZZ, Worrell C, Vandenberg O, Pieters I, Victorien DT, Salazar Gutierrez AD, Soria F, Rudić Grujić V, Mazalica N, Rahube TO, Tagliati CA, Rodrigues D, Oliveira G, Ribeiro de Souza J LC, Ivanov I, Juste BI, Oumar T, Sopheak T, Vuthy Y, Ngandijo A, Nzouankeu A, Abah Jacques Olivier ZA, Yost CK, Kumar P, Brar SK, Tabo DA, Adell AD, Paredes-Osses E, Martinez MC, Cuadros-Orellana S, Ke C, Zheng H, Baisheng L, Lau LT, Chung T, Jiao X, Yu Y, JiaYong Z, Bernal Morales JF, Valencia MF, Donado-Godoy P, Coulibaly KJ, Hrenović J, Jergović M, Karpíšková R, Deogratias ZN, Elsborg B, Truelstrup Hansen L, Erland Jensen P, Abouelnaga M, Salem MF, Koolmeister M, Legesse M, Eguale T, Heikinheimo A, Le Guyader S, Schaeffer J, Villacis JE, Sanneh B, Malania L, Nitsche A, Brinkmann A, Schubert S, Hesse S, Berendonk TU, Setsoafia Saba CK, Mohammed J, Feglo PK, Banu RA, Kotzamanidis C, Lytras E, Lickes SA, Kocsis B, Solymosi N, Thorsteinsdottir TR, Hatha AM, Ballal M, Bangera SR, Fani F, Alebouyeh M, Morris D, O’Connor L, Cormican M, Moran-Gilad J, Battisti A, Diaconu EL, Corno G, Di Cesare A, Alba P, Hisatsune J, Yu L, Kuroda M, Sugai M, Kayama S, Shakenova Z, Kiiyukia C, Ng’eno E, Raka L, Jamil K, Fakhraldeen SA, Alaati T, Bērziņš A, Avsejenko J, Kokina K, Streikisa M, Bartkevics V, Matar GM, Daoud Z, Pereckienė A, Butrimaite-Ambrozeviciene C, Penny C, Bastaraud A, Rasolofoarison T, Collard JM, Hervé Samison L, Rakoto Andrianarivelo M, Lawadi Banda D, Amin A, Rajandas H, Parimannan S, Spiteri D, Haber MV, Santchurn SJ, Vujacic A, Djurovic D, Bouchrif B, Karraouan B, Vubil DC, Pal P, Schmitt H, van Passel M, Jeunen G, Gemmell N, Chambers ST, Perez Mendoza F, Huete-Pιrez J, Vilchez S, Ahmed AO, Adisa IR, Odetokun IA, Fashae K, Sørgaard A, Wester AL, Ryrfors P, Holmstad R, Mohsin M, Hasan R, Shakoor S, Gustafson NW, Huber Schill C, Zamudio Rojas ML, Velasquez JE, Magtibay BB, Catangcatang K, Sibulo R, Yauce FC, Wasyl D, Manaia C, Rocha J, Martins J, Álvaro P, Wen DDY, Shin H, Hur H, Yoon S, Bosevska G, Kochubovski M, Cojocaru R, Burduniuc O, Hong P, Perry MR, Gassama A, Radosavljevic V, Tay MYF, Zuniga-Montanez R, Wuertz S, Gavačová D, Pastuchová K, Truska P, Trkov M, Keddy K, Esterhuyse K, Song MJ, Quintela- Baluja M, Gomez Lopez M, Cerdà-Cuéllar M, Perera RRDP, Bandara NKBKRGW, Premasiri H. I., Pathirage S, Charlemagne K, Rutgersson C, Norrgren L, Örn S, Boss R, Van der Heijden T, Hong Y, Kumburu HH, Mdegela RH, Hounmanou YMG, Chonsin K, Suthienkul O, Thamlikitkul V, de Roda Husman A, Bidjada B, Njanpop-Lafourcade BM, Nikiema-Pessinaba SC, Levent B, Kurekci C, Ejobi F, Kalule JB, Thomsen J, Obaidi O, Jassim LM, Moore A, Leonard A, Graham DW, Bunce JT, Zhang L, Gaze WH, Lefor B, Capone D, Sozzi E, Brown J, Meschke JS, Sobsey MD, Davis M, Beck NK, Sukapanpatharam P, Truong P, Lilienthal R, Kang S, Wittum TE, Rigamonti N, Baklayan P, Van CD, Tran DMN, Phuc ND & Kwenda G) ; Larsson DGJ ; Koopmans M ; Woolhouse M ; Aarestrup FM.

Kolaboracija
Sewage Surveillance Consortium

Izvornik
Nature Communications (2041-1723) 13 (2022), 7251; 16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
genomic analysis, sewage, antimicrobial resistance

Sažetak
Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019.We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA