Naslov
Brachial flow-mediated dilation and carotid intima- media thickness in glaucoma patients

Autori
Bojić, Lovro ; Rogošić, Veljko ; Marković, Domagoj ; Vanjaka Rogošić, Lucija ; Glavaš, Duška

Izvornik
BMC Ophthalmology (1471-2415) 22 (2022), 1; 275, 6

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Glaucoma ; Flow-mediated dilation ; Brachial artery ; Carotid artery ; Intima-media thickness

Sažetak
Background: The purpose of the study was to assess the ultrasound measurements of the brachial artery flow-mediated dilation (FMD) and carotid artery intima-media thickness (IMT) and their relationship in glaucoma patients. Methods: Thirty-seven patients with glaucoma and thirty-one healthy controls were included in the study. All glaucoma patients and controls underwent ultrasound measurement of FMD of the brachial artery and ultrasound measurement of IMT of the carotid artery. Results: The mean values of brachial FMD were significantly lower among the glaucoma compared with controls (16.4 +/- 10.6% vs 20.3 +/- 8.5%, p = 0.034). No significant difference was found in carotid IMT (1.2 +/- 0.4 vs. 1.1 +/- 0.4, p = 0.3), and brachial artery diameter at rest (4.7 +/- 0.6 vs. 4.9 +/- 0.3, p = 0.2) between the glaucoma patients and controls. The significant difference in brachial artery diameter in hyperemia between the glaucoma patients and controls (5.5 +/- 0.6 vs. 5.9 +/- 0.4 p = 0.002) was found. A negative correlation among brachial FMD and carotid IMT as well as among brachial FMD and brachial artery diameter at rest was found. Conclusions: Impaired brachial FMD indicates presence of systemic vascular endothelial dysfunction in glaucoma ; glaucoma patients with lower values of the brachial FMD are at increased risk of having thickened carotid IMT.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA