Naslov
Understanding and treating itching and scratching

Autori
Čarija A, Vuković D, Bojčić I, Ivanišević R, Stipić T, Pezelj D, Anđelinović D, Puizina Ivić N

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
6. kongres hrvatskih dermatologa s međ. sudjelovanjem

Mjesto i datum
Pula, Hrvatska, 04.-07.10.2018

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
pruritus, itch, pathogenesis

Sažetak
Pruritus (or itch) is an unpleasant sensory perception which causes an intense desire to scratch. Chronic pruritus, one of the main symptoms in dermatology, is often intractable and has a high impact on patient's quality of life. According to a cross-sectional study in Oslo, acute pruritus affects 8.4% of the general population, while in a large French study 42% of patients with skin diseases stated that they experienced pruritus. Several classifications have been published, considering these different aetiologies and clinical morphologies of chronic pruritus. The International Forum for the Study of Itch (IFSI) has proposed a classification, which considers clinical as well as differential diagnostic reasons. The pathogenesis of chronic pruritus is complex and involves in the skin a network of residet and transient inflammatory cells. In the skin, several classes of histamine-sensitive or histamine- insensitve C-fibers are involved in itch transmission. Specific receptors have been discovered on cutaneous and spinal neurons to be exclusively involved in the processing of pruritic signals. Pruritus management is challenging, as many therapies fail. Because chronic pruritus is a complex, multifactorial phenomenon, no generally accepted concept exists, and many circumstances prevent optimal treatment. Due to the huge variety of systemic origins of pruritus, a successful therapeutic regimen implies a thorough screening for any underlying disease. An individualized approach, which combines systemical and topical therapy, is necessary. Itch researchers seek to understand the mechanisms behind itch and to find potential targets for treatment. A major step forward include the identification of new peripheral and central itch mediators and modulators, the discovery of greater roles for immune cells and glia in itch transmission, and a focus on the brain processing of itching and scratching. Finally, several new therapeutic interventions for itch have shown success in clinical trials.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA