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Pregled bibliografske jedinice broj: 1238038

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

(Lifelines Cohort Study) Wang, Zhe; Emmerich, Andrew; Pillon, Nicolas J.; Moore, Tim; Hemerich, Daiane; Cornelis, Marilyn C.; Mazzaferro, Eugenia; Broos, Siacia; Ahluwalia, Tarunveer S.; Bartz, Traci M. et al.
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention // Nature genetics, 54 (2022), 9; 1332-1344 doi:10.1038/s41588-022-01165-1 (međunarodna recenzija, članak, znanstveni)

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Naslov
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Autori
Wang, Zhe ; Emmerich, Andrew ; Pillon, Nicolas J. ; Moore, Tim ; Hemerich, Daiane ; Cornelis, Marilyn C. ; Mazzaferro, Eugenia ; Broos, Siacia ; Ahluwalia, Tarunveer S. ; Bartz, Traci M. ; Bentley, Amy R. ; Bielak, Lawrence F. ; Chong, Mike ; Chu, Audrey Y. ; Berry, Diane ; Dorajoo, Rajkumar ; Dueker, Nicole D. ; Kasbohm, Elisa ; Feenstra, Bjarke ; Feitosa, Mary F. ; Gieger, Christian ; Graff, Mariaelisa ; Hall, Leanne M. ; Haller, Toomas ; Hartwig, Fernando P. ; Hillis, David A. ; Huikari, Ville ; Heard-Costa, Nancy ; Holzapfel, Christina ; Jackson, Anne U. ; Johansson, Asa ; Jorgensen, Anja Moltke ; Kaakinen, Marika A. ; Karlsson, Robert ; Kerr, Kathleen F. ; Kim, Boram ; Koolhaas, Chantal M. ; Kutalik, Zoltan ; Lagou, Vasiliki ; Lind, Penelope A. ; Lorentzon, Mattias ; Lyytikainen, Leo-Pekka ; Mangino, Massimo ; Metzendorf, Christoph ; Monroe, Kristine R. ; Pacolet, Alexander ; Perusse, Louis ; Pool, Rene ; Richmond, Rebecca C. ; Rivera, Natalia, V ; Robiou- Du-Pont, Sebastien ; Schraut, Katharina E. ; Schulz, Christina-Alexandra ; Stringham, Heather M. ; Tanaka, Toshiko ; Teumer, Alexander ; Turman, Constance ; Van der Most, Peter J. ; Vanmunster, Mathias ; Van Rooij, Frank J. A. ; Van Vliet- Ostaptchouk, Jana V. ; Zhang, Xiaoshuai ; Zhao, Jing-Hua ; Zhao, Wei ; Balkhiyarova, Zhanna ; Balslev-Harder, Marie N. ; Baumeister, Sebastian E. ; Beilby, John ; Blangero, John ; Boomsma, Dorret, I ; Brage, Soren ; Braund, Peter S. ; Brody, Jennifer A. ; Bruinenberg, Marcel ; Ekelund, Ulf ; Liu, Ching- Ti ; Cole, John W. ; Collins, Francis S. ; Cupples, L. Adrienne ; Esko, Tonu ; Enroth, Stefan ; Faul, Jessica D. ; Fernandez-Rhodes, Lindsay ; Fohner, Alison E. ; Franco, Oscar H. ; Galesloot, Tessel E. ; Gordon, Scott D. ; Grarup, Niels ; Hartman, Catharina A. ; Heiss, Gerardo ; Hui, Jennie ; Illig, Thomas ; Jago, Russell ; James, Alan ; Joshi, Peter K. ; Jung, Taeyeong ; Kahonen, Mika ; Kilpelainen, Tuomas O. ; Koh, Woon-Puay ; Kolčić, Ivana ; Kraft, Peter P. ; Kuusisto, Johanna ; Launer, Lenore J. ; Li, Aihua ; Linneberg, Allan ; Luan, Jian'An ; Vidal, Pedro Marques ; Medland, Sarah E. ; Milaneschi, Yuri ; Moscati, Arden ; Musk, Bill ; Nelson, Christopher P. ; Nolte, Ilja M. ; Pedersen, Nancy L. ; Peters, Annette ; Peyser, Patricia A. ; Power, Christine ; Raitakari, Olli T. ; Reedik, Magi ; Reiner, Alex P. ; Ridker, Paul M. ; Rudan, Igor ; Ryan, Kathy ; Sarzynski, Mark A. ; Scott, Laura J. ; Scott, Robert A. ; Sidney, Stephen ; Siggeirsdottir, Kristin ; Smith, Albert, V ; Smith, Jennifer A. ; Sonestedt, Emily ; Strom, Marin ; Tai, E. Shyong ; Teo, Koon K. ; Thorand, Barbara ; Toenjes, Anke ; Tremblay, Angelo ; Uitterlinden, Andre G. ; Vangipurapu, Jagadish ; Van Schoor, Natasja ; Volker, Uwe ; Willemsen, Gonneke ; Williams, Kayleen ; Wong, Quenna ; Xu, Huichun ; Young, Kristin L. ; Yuan, Jian Min ; Zillikens, M. Carola ; Zonderman, Alan B. ; Ameur, Adam ; Bandinelli, Stefania ; Bis, Joshua C. ; Boehnke, Michael ; Bouchard, Claude ; Chasman, Daniel, I ; Smith, George Davey ; De Geus, Eco J. C. ; Deldicque, Louise ; Dorr, Marcus ; Evans, Michele K. ; Ferrucci, Luigi ; Fornage, Myriam ; Fox, Caroline ; Garland, Theodore, Jr. ; Gudnason, Vilmundur ; Gyllensten, Ulf ; Hansen, Torben ; Hayward, Caroline ; Horta, Bernardo L. ; Hypponen, Elina ; Jarvelin, Marjo- Riitta ; Johnson, W. Craig ; Kardia, Sharon L. R. ; Kiemeney, Lambertus A. ; Laakso, Markku ; Langenberg, Claudia ; Lehtimaki, Terho ; Le Marchand, Loic ; Magnusson, Patrik K. E. ; Martin, Nicholas G. ; Melbye, Mads ; Metspalu, Andres ; Meyre, David ; North, Kari E. ; Ohlsson, Claes ; Oldehinkel, Albertine J. ; Orho-Melander, Marju ; Pare, Guillaume ; Park, Taesung ; Pedersen, Oluf ; Penninx, Brenda W. J. H. ; Pers, Tune H. ; Polašek, Ozren ; Prokopenko, Inga ; Rotimi, Charles N. ; Samani, Nilesh J. ; Sim, Xueling ; Snieder, Harold ; Sorensen, Thorkild I. A. ; Spector, Tim D. ; Timpson, Nicholas J. ; Van Dam, Rob M. ; Van der Velde, Nathalie ; Van Duijn, Cornelia M. ; Vollenweider, Peter ; Volzke, Henry ; Voortman, Trudy ; Waeber, Gerard ; Wareham, Nicholas J. ; Weir, David R. ; Wichmann, Heinz-Erich ; Wilson, James F. ; Hevener, Andrea L. ; Krook, Anna ; Zierath, Juleen R. ; Thomis, Martine A., I ; Loos, Ruth J. F. ; Den Hoed, Marcel

Kolaboracija
Lifelines Cohort Study

Izvornik
Nature genetics (1061-4036) 54 (2022), 9; 1332-1344

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
APOLIPOPROTEIN-E GENOTYPE ; LD SCORE REGRESSION ; GENE-EXPRESSION ; EXERCISE ; COMPLEX ; PERFORMANCE ; GWAS ; HERITABILITY ; MORTALITY ; FITNESS

Sažetak
Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703, 901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to- vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise- induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention. Multi-ancestry meta-analyses of genome-wide association studies for self-reported physical activity during leisure time, leisure screen time, sedentary commuting and sedentary behavior at work identify 99 loci associated with at least one of these traits.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Avatar Url Igor Rudan (autor)

Avatar Url Ivana Kolčić (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

(Lifelines Cohort Study) Wang, Zhe; Emmerich, Andrew; Pillon, Nicolas J.; Moore, Tim; Hemerich, Daiane; Cornelis, Marilyn C.; Mazzaferro, Eugenia; Broos, Siacia; Ahluwalia, Tarunveer S.; Bartz, Traci M. et al.
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention // Nature genetics, 54 (2022), 9; 1332-1344 doi:10.1038/s41588-022-01165-1 (međunarodna recenzija, članak, znanstveni)
(Lifelines Cohort Study) (Lifelines Cohort Study) Wang, Z., Emmerich, A., Pillon, N., Moore, T., Hemerich, D., Cornelis, M., Mazzaferro, E., Broos, S., Ahluwalia, T. & Bartz, T. (2022) Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention. Nature genetics, 54 (9), 1332-1344 doi:10.1038/s41588-022-01165-1.
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A. and Van Vliet- Ostaptchouk, Jana V. and Zhang, Xiaoshuai and Zhao, Jing-Hua and Zhao, Wei and Balkhiyarova, Zhanna and Balslev-Harder, Marie N. and Baumeister, Sebastian E. and Beilby, John and Blangero, John and Brage, Soren and Braund, Peter S. and Brody, Jennifer A. and Bruinenberg, Marcel and Ekelund, Ulf and Liu, Ching- Ti and Cole, John W. and Collins, Francis S. and Cupples, L. Adrienne and Esko, Tonu and Enroth, Stefan and Faul, Jessica D. and Fernandez-Rhodes, Lindsay and Fohner, Alison E. and Franco, Oscar H. and Galesloot, Tessel E. and Gordon, Scott D. and Grarup, Niels and Hartman, Catharina A. and Heiss, Gerardo and Hui, Jennie and Illig, Thomas and Jago, Russell and James, Alan and Joshi, Peter K. and Jung, Taeyeong and Kahonen, Mika and Kilpelainen, Tuomas O. and Koh, Woon-Puay and Kol\v{c}i\'{c}, Ivana and Kraft, Peter P. and Kuusisto, Johanna and Launer, Lenore J. and Li, Aihua and Linneberg, Allan and Luan, Jian'An and Vidal, Pedro Marques and Medland, Sarah E. and Milaneschi, Yuri and Moscati, Arden and Musk, Bill and Nelson, Christopher P. and Nolte, Ilja M. and Pedersen, Nancy L. and Peters, Annette and Peyser, Patricia A. and Power, Christine and Raitakari, Olli T. and Reedik, Magi and Reiner, Alex P. and Ridker, Paul M. and Rudan, Igor and Ryan, Kathy and Sarzynski, Mark A. and Scott, Laura J. and Scott, Robert A. and Sidney, Stephen and Siggeirsdottir, Kristin and Smith, Jennifer A. and Sonestedt, Emily and Strom, Marin and Tai, E. Shyong and Teo, Koon K. and Thorand, Barbara and Toenjes, Anke and Tremblay, Angelo and Uitterlinden, Andre G. and Vangipurapu, Jagadish and Van Schoor, Natasja and Volker, Uwe and Willemsen, Gonneke and Williams, Kayleen and Wong, Quenna and Xu, Huichun and Young, Kristin L. and Yuan, Jian Min and Zillikens, M. Carola and Zonderman, Alan B. and Ameur, Adam and Bandinelli, Stefania and Bis, Joshua C. and Boehnke, Michael and Bouchard, Claude and Smith, George Davey and De Geus, Eco J. C. and Deldicque, Louise and Dorr, Marcus and Evans, Michele K. and Ferrucci, Luigi and Fornage, Myriam and Fox, Caroline and Gudnason, Vilmundur and Gyllensten, Ulf and Hansen, Torben and Hayward, Caroline and Horta, Bernardo L. and Hypponen, Elina and Jarvelin, Marjo- Riitta and Johnson, W. Craig and Kardia, Sharon L. R. and Kiemeney, Lambertus A. and Laakso, Markku and Langenberg, Claudia and Lehtimaki, Terho and Le Marchand, Loic and Magnusson, Patrik K. E. and Martin, Nicholas G. and Melbye, Mads and Metspalu, Andres and Meyre, David and North, Kari E. and Ohlsson, Claes and Oldehinkel, Albertine J. and Orho-Melander, Marju and Pare, Guillaume and Park, Taesung and Pedersen, Oluf and Penninx, Brenda W. J. H. and Pers, Tune H. and Pola\v{s}ek, Ozren and Prokopenko, Inga and Rotimi, Charles N. and Samani, Nilesh J. and Sim, Xueling and Snieder, Harold and Sorensen, Thorkild I. A. and Spector, Tim D. and Timpson, Nicholas J. and Van Dam, Rob M. and Van der Velde, Nathalie and Van Duijn, Cornelia M. and Vollenweider, Peter and Volzke, Henry and Voortman, Trudy and Waeber, Gerard and Wareham, Nicholas J. and Weir, David R. and Wichmann, Heinz-Erich and Wilson, James F. and Hevener, Andrea L. and Krook, Anna and Zierath, Juleen R. and Loos, Ruth J. F. and Den Hoed, Marcel}, year = {2022}, pages = {1332-1344}, DOI = {10.1038/s41588-022-01165-1}, keywords = {APOLIPOPROTEIN-E GENOTYPE, LD SCORE REGRESSION, GENE-EXPRESSION, EXERCISE, COMPLEX, PERFORMANCE, GWAS, HERITABILITY, MORTALITY, FITNESS}, journal = {Nature genetics}, doi = {10.1038/s41588-022-01165-1}, volume = {54}, number = {9}, issn = {1061-4036}, title = {Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention}, keyword = {APOLIPOPROTEIN-E GENOTYPE, LD SCORE REGRESSION, GENE-EXPRESSION, EXERCISE, COMPLEX, PERFORMANCE, GWAS, HERITABILITY, MORTALITY, FITNESS} }
@article{article, author = {Wang, Zhe and Emmerich, Andrew and Pillon, Nicolas J. and Moore, Tim and Hemerich, Daiane and Cornelis, Marilyn C. and Mazzaferro, Eugenia and Broos, Siacia and Ahluwalia, Tarunveer S. and Bartz, Traci M. and Bentley, Amy R. and Bielak, Lawrence F. and Chong, Mike and Chu, Audrey Y. and Berry, Diane and Dorajoo, Rajkumar and Dueker, Nicole D. and Kasbohm, Elisa and Feenstra, Bjarke and Feitosa, Mary F. and Gieger, Christian and Graff, Mariaelisa and Hall, Leanne M. and Haller, Toomas and Hartwig, Fernando P. and Hillis, David A. and Huikari, Ville and Heard-Costa, Nancy and Holzapfel, Christina and Jackson, Anne U. and Johansson, Asa and Jorgensen, Anja Moltke and Kaakinen, Marika A. and Karlsson, Robert and Kerr, Kathleen F. and Kim, Boram and Koolhaas, Chantal M. and Kutalik, Zoltan and Lagou, Vasiliki and Lind, Penelope A. and Lorentzon, Mattias and Lyytikainen, Leo-Pekka and Mangino, Massimo and Metzendorf, Christoph and Monroe, Kristine R. and Pacolet, Alexander and Perusse, Louis and Pool, Rene and Richmond, Rebecca C. and Robiou- Du-Pont, Sebastien and Schraut, Katharina E. and Schulz, Christina-Alexandra and Stringham, Heather M. and Tanaka, Toshiko and Teumer, Alexander and Turman, Constance and Van der Most, Peter J. and Vanmunster, Mathias and Van Rooij, Frank J. A. and Van Vliet- Ostaptchouk, Jana V. and Zhang, Xiaoshuai and Zhao, Jing-Hua and Zhao, Wei and Balkhiyarova, Zhanna and Balslev-Harder, Marie N. and Baumeister, Sebastian E. and Beilby, John and Blangero, John and Brage, Soren and Braund, Peter S. and Brody, Jennifer A. and Bruinenberg, Marcel and Ekelund, Ulf and Liu, Ching- Ti and Cole, John W. and Collins, Francis S. and Cupples, L. Adrienne and Esko, Tonu and Enroth, Stefan and Faul, Jessica D. and Fernandez-Rhodes, Lindsay and Fohner, Alison E. and Franco, Oscar H. and Galesloot, Tessel E. and Gordon, Scott D. and Grarup, Niels and Hartman, Catharina A. and Heiss, Gerardo and Hui, Jennie and Illig, Thomas and Jago, Russell and James, Alan and Joshi, Peter K. and Jung, Taeyeong and Kahonen, Mika and Kilpelainen, Tuomas O. and Koh, Woon-Puay and Kol\v{c}i\'{c}, Ivana and Kraft, Peter P. and Kuusisto, Johanna and Launer, Lenore J. and Li, Aihua and Linneberg, Allan and Luan, Jian'An and Vidal, Pedro Marques and Medland, Sarah E. and Milaneschi, Yuri and Moscati, Arden and Musk, Bill and Nelson, Christopher P. and Nolte, Ilja M. and Pedersen, Nancy L. and Peters, Annette and Peyser, Patricia A. and Power, Christine and Raitakari, Olli T. and Reedik, Magi and Reiner, Alex P. and Ridker, Paul M. and Rudan, Igor and Ryan, Kathy and Sarzynski, Mark A. and Scott, Laura J. and Scott, Robert A. and Sidney, Stephen and Siggeirsdottir, Kristin and Smith, Jennifer A. and Sonestedt, Emily and Strom, Marin and Tai, E. Shyong and Teo, Koon K. and Thorand, Barbara and Toenjes, Anke and Tremblay, Angelo and Uitterlinden, Andre G. and Vangipurapu, Jagadish and Van Schoor, Natasja and Volker, Uwe and Willemsen, Gonneke and Williams, Kayleen and Wong, Quenna and Xu, Huichun and Young, Kristin L. and Yuan, Jian Min and Zillikens, M. Carola and Zonderman, Alan B. and Ameur, Adam and Bandinelli, Stefania and Bis, Joshua C. and Boehnke, Michael and Bouchard, Claude and Smith, George Davey and De Geus, Eco J. C. and Deldicque, Louise and Dorr, Marcus and Evans, Michele K. and Ferrucci, Luigi and Fornage, Myriam and Fox, Caroline and Gudnason, Vilmundur and Gyllensten, Ulf and Hansen, Torben and Hayward, Caroline and Horta, Bernardo L. and Hypponen, Elina and Jarvelin, Marjo- Riitta and Johnson, W. Craig and Kardia, Sharon L. R. and Kiemeney, Lambertus A. and Laakso, Markku and Langenberg, Claudia and Lehtimaki, Terho and Le Marchand, Loic and Magnusson, Patrik K. E. and Martin, Nicholas G. and Melbye, Mads and Metspalu, Andres and Meyre, David and North, Kari E. and Ohlsson, Claes and Oldehinkel, Albertine J. and Orho-Melander, Marju and Pare, Guillaume and Park, Taesung and Pedersen, Oluf and Penninx, Brenda W. J. H. and Pers, Tune H. and Pola\v{s}ek, Ozren and Prokopenko, Inga and Rotimi, Charles N. and Samani, Nilesh J. and Sim, Xueling and Snieder, Harold and Sorensen, Thorkild I. A. and Spector, Tim D. and Timpson, Nicholas J. and Van Dam, Rob M. and Van der Velde, Nathalie and Van Duijn, Cornelia M. and Vollenweider, Peter and Volzke, Henry and Voortman, Trudy and Waeber, Gerard and Wareham, Nicholas J. and Weir, David R. and Wichmann, Heinz-Erich and Wilson, James F. and Hevener, Andrea L. and Krook, Anna and Zierath, Juleen R. and Loos, Ruth J. F. and Den Hoed, Marcel}, year = {2022}, pages = {1332-1344}, DOI = {10.1038/s41588-022-01165-1}, keywords = {APOLIPOPROTEIN-E GENOTYPE, LD SCORE REGRESSION, GENE-EXPRESSION, EXERCISE, COMPLEX, PERFORMANCE, GWAS, HERITABILITY, MORTALITY, FITNESS}, journal = {Nature genetics}, doi = {10.1038/s41588-022-01165-1}, volume = {54}, number = {9}, issn = {1061-4036}, title = {Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention}, keyword = {APOLIPOPROTEIN-E GENOTYPE, LD SCORE REGRESSION, GENE-EXPRESSION, EXERCISE, COMPLEX, PERFORMANCE, GWAS, HERITABILITY, MORTALITY, FITNESS} }

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