Naslov
The incidence, treatment and outcome of posttraumatic epilepsy in one Croatian general hospital in a period of 20 years
(The incidence, treatment and outcome of posttraumatic epilepsy in one Croatian general hospital in a period of 20 years)

Autori
Bujan Kovač, Andreja ; Hajnšek, Sanja ; Šapina, Lidija ; Petelin Gadže, Željka ; Nanković, Sibila ; Čajić, Ivana ; Šulentić, Vlatko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Neurology / - , 2015, 502-502

Skup
1st Congress of the European Academy of Neurology

Mjesto i datum
Berlin, Njemačka, 20.-23.6.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
incidence, treatment, outcome, posttraumatic epilepsy

Sažetak
Background and aims: Posttraumatic epilepsy, as frequent complication of traumatic brain injury (TBI) requires careful diagnosis, proper selection of antiepileptic drugs (AEDs) and follow-up. Prognosis is usually favorable but some patients develop pharmacoresistant epilepsy. Methods and Materials: The study included 113 patients with post-traumatic epilepsy (PTE), 46 females and 67 males in period from 1998-2008. 51% of the patients had mild TBI, 5% moderate, and 43% severe. Most of the patients (50%) had complex partial seizures (CPS) with secondary generalized tonic-clonic seizures (GTCS), 28% had GTCS, 8% CPS, 4% elementary partial seizures (EPS) with GTCS, 2% had isolated EPS and 8% had combination of partial and generalized seizures. Neuroimaging (brain MRI and CT) showed gliosis in 57% patients, localized atrophy in 11%, in 6% gliosis with atrophy and 27% of the patients had normal neuroimaging findings. 60.2% of the patient were treated with one or more conventional AEDs and 39.8% with at least one of the new AEDs. Results: Patients treated with conventional AEDs achieved remission in 73% of cases and those treated with at least one of the new AEDs in 77%, and in this group remission was attained earlier (1.6 months compared to 1.85 months). Diagnozed psychiatric comorbidity lengthened the average time to remission in both groups - 3.4 months. Conclusion: Therapy with AEDs of the new generation leads to earlier and more complete remission of post-traumatic epilepsy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA