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Pregled bibliografske jedinice broj: 1237456

Cerebrovascular function is preserved during mild hyperthermia in cervical spinal cord injury

Coombs, Geoff B.; Vučina, Diana; Caldwell, Hannah G.; Barak, Otto F.; Mijačika, Tanja; Lee, Amanda H. X.; Sarafis, Zoe K.; Squair, Jordan W.; Krassioukov, Andrei, V; Phillips, Aaron A. et al.
Cerebrovascular function is preserved during mild hyperthermia in cervical spinal cord injury // Spinal cord, 57 (2019), 11; 979-984 doi:10.1038/s41393-019-0321-1 (međunarodna recenzija, članak, znanstveni)

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Naslov
Cerebrovascular function is preserved during mild hyperthermia in cervical spinal cord injury

Autori
Coombs, Geoff B. ; Vučina, Diana ; Caldwell, Hannah G. ; Barak, Otto F. ; Mijačika, Tanja ; Lee, Amanda H. X. ; Sarafis, Zoe K. ; Squair, Jordan W. ; Krassioukov, Andrei, V ; Phillips, Aaron A. ; Dujić, Željko ; Ainslie, Philip N.

Izvornik
Spinal cord (1362-4393) 57 (2019), 11; 979-984

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ARTERIAL STIFFNESS ; BLOOD-PRESSURE ; RESPONSES ; DISEASE ; METABOLISM ; EXERCISE

Sažetak
Study design Experimental study. Objectives Compromised cerebrovascular function likely contributes to elevated neurological risk in spinal cord injury (SCI). Passive heating offers many cardiovascular and neurological health benefits ; therefore, we aimed to determine the effects of an acute bout of heating on cerebrovascular function in chronic SCI. Methods Persons with cervical SCI (n = 15) and uninjured controls (CON ; n = 15) completed 60 min of lower limb hot water immersion (40 degrees C). Assessments of middle cerebral (MCA) and posterior cerebral artery (PCA) velocities, pulsatilities, and neurovascular coupling (NVC) were performed using transcranial Doppler ultrasound. Duplex ultrasonography was used to index cerebral blood flow via the internal carotid artery (ICA), and carotid-femoral pulse-wave velocity (PWV) was measured using tonometry. The NVC response was quantified as the peak hyperemic value during 30-s cycles of visual stimulation. Results Mean arterial pressure changed differentially with heating [mean (standard deviation) ; SCI: +6(14) mmHg, CON: -8(12) mmHg ; P = 0 .01]. There were no differences in any intracranial artery measures (all P > 0.05), except for small (similar to 10%) increases in MCA conductance in CON after heating vs. SCI (interaction P = 0.006). Resting ICA flow was greater in SCI vs. CON (P = 0.03) but did not change with heating in either group (interaction P = 0.34). There were also no between-group differences in the NVC response (Delta PCA conductance) pre- [SCI: 29(19)% vs. CON: 30(9)%] or post-heating [SCI 30(9)% vs. 25(9)% ; interaction P = 0.22]. Conclusions Mild acute heating does not impair or improve cerebrovascular function in SCI or CON. Thus, further study of the effects of chronic heating interventions are warranted.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Željko Dujić (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Coombs, Geoff B.; Vučina, Diana; Caldwell, Hannah G.; Barak, Otto F.; Mijačika, Tanja; Lee, Amanda H. X.; Sarafis, Zoe K.; Squair, Jordan W.; Krassioukov, Andrei, V; Phillips, Aaron A. et al.
Cerebrovascular function is preserved during mild hyperthermia in cervical spinal cord injury // Spinal cord, 57 (2019), 11; 979-984 doi:10.1038/s41393-019-0321-1 (međunarodna recenzija, članak, znanstveni)
Coombs, G., Vučina, D., Caldwell, H., Barak, O., Mijačika, T., Lee, A., Sarafis, Z., Squair, J., Krassioukov, Andrei, V & Phillips, A. (2019) Cerebrovascular function is preserved during mild hyperthermia in cervical spinal cord injury. Spinal cord, 57 (11), 979-984 doi:10.1038/s41393-019-0321-1.
@article{article, author = {Coombs, Geoff B. and Vu\v{c}ina, Diana and Caldwell, Hannah G. and Barak, Otto F. and Mija\v{c}ika, Tanja and Lee, Amanda H. X. and Sarafis, Zoe K. and Squair, Jordan W. and Phillips, Aaron A. and Duji\'{c}, \v{Z}eljko and Ainslie, Philip N.}, year = {2019}, pages = {979-984}, DOI = {10.1038/s41393-019-0321-1}, keywords = {ARTERIAL STIFFNESS, BLOOD-PRESSURE, RESPONSES, DISEASE, METABOLISM, EXERCISE}, journal = {Spinal cord}, doi = {10.1038/s41393-019-0321-1}, volume = {57}, number = {11}, issn = {1362-4393}, title = {Cerebrovascular function is preserved during mild hyperthermia in cervical spinal cord injury}, keyword = {ARTERIAL STIFFNESS, BLOOD-PRESSURE, RESPONSES, DISEASE, METABOLISM, EXERCISE} }
@article{article, author = {Coombs, Geoff B. and Vu\v{c}ina, Diana and Caldwell, Hannah G. and Barak, Otto F. and Mija\v{c}ika, Tanja and Lee, Amanda H. X. and Sarafis, Zoe K. and Squair, Jordan W. and Phillips, Aaron A. and Duji\'{c}, \v{Z}eljko and Ainslie, Philip N.}, year = {2019}, pages = {979-984}, DOI = {10.1038/s41393-019-0321-1}, keywords = {ARTERIAL STIFFNESS, BLOOD-PRESSURE, RESPONSES, DISEASE, METABOLISM, EXERCISE}, journal = {Spinal cord}, doi = {10.1038/s41393-019-0321-1}, volume = {57}, number = {11}, issn = {1362-4393}, title = {Cerebrovascular function is preserved during mild hyperthermia in cervical spinal cord injury}, keyword = {ARTERIAL STIFFNESS, BLOOD-PRESSURE, RESPONSES, DISEASE, METABOLISM, EXERCISE} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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