Naslov
Effect of cyclodextrins on solubility enhancement of loratadine

Autori
Pocrnić, Marijana ; Galić, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
V. Simpozij Supramolekulske kemije - Knjiga sažetaka / Frkanec, Leo ; Namjesnik, Danijel ; Tomišić, Vladislav - Zagreb : Institut Ruđer Bošković, 2022, 34-34

Skup
V. simpozij supramolekulske kemije: Supramolecular Chemistry

Mjesto i datum
Zagreb, Hrvatska, 08.12.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
loratadine ; cyclodextrins ; solubility

Sažetak
Loratadine (LOR) is antihistaminic drug, classified as BCS class II drug due to its low solubility and high permeability. Cyclodextrins (CD) are cyclic oligosaccharides containing 6 (α-CD), 7 (β-CD) or 8 (γ-CD) glucose subunits linked with (α-1, 4)-glycosidic bond. Their cone like shape with hydrophobic cavity and hydrophilic surface enables formation of inclusion complexes with drugs, which affects physicochemical properties of drugs, such as solubility and stability. The influence of natural cyclodextrins (α-CD, β- CD, γ-CD) and its hydroxypropyl derivative (HPβCD) on LOR solubility in water and buffered solutions at different pH has already been studied. However solubility in biorelevant media has not been studied yet. The aim of this study was to investigate the influence of β-CD and its hydroxypropyl (HPβCD), randomly methylated (RMβCD) and sulfobutylether (SBEβCD) derivatives on the solubility of LOR in water and simulated intestinal media (pH 6.8). Based on the enhancement of solubility, β-CD and HPβCD were selected for phase solubility studies, performed according to the method presented by Higuchi and Connors. Phase solubility diagrams were constructed, and stability constants, complexation efficacies and solubility enhancement were determined.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA