Pregled bibliografske jedinice broj: 1236927
Analysis of the Human Protein Atlas Weakly Supervised Single-Cell Classification competition
Analysis of the Human Protein Atlas Weakly Supervised Single-Cell Classification competition // Nature methods, 19 (2022), 10; 1221-1229 doi:10.1038/s41592-022-01606-z (međunarodna recenzija, članak, znanstveni)
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Naslov
Analysis of the Human Protein Atlas Weakly Supervised Single-Cell Classification competition
Autori
Le, Trang ; Winsnes, Casper F. ; Axelsson, Ulrika ; Xu, Hao ; Mohanakrishnan Kaimal, Jayasankar ; Mahdessian, Diana ; Dai, Shubin ; Makarov, Ilya S. ; Ostankovich, Vladislav ; Xu, Yang ; Benhamou, Eric ; Henkel, Christof ; Solovyev, Roman A. ; Banić, Nikola ; Bošnjak, Vito ; Bošnjak, Ana ; Miličević, Andrija ; Ouyang, Wei ; Lundberg, Emma
Izvornik
Nature methods (1548-7091) 19
(2022), 10;
1221-1229
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
fluorescence imaging ; human protein atlas ; single-cell classification ; single-cell features ; cellular dynamics
Sažetak
While spatial proteomics by fluorescence imaging has quickly become an essential discovery tool for researchers, fast and scalable methods to classify and embed single-cell protein distributions in such images are lacking. Here, we present the design and analysis of the results from the competition Human Protein Atlas – Single-Cell Classification hosted on the Kaggle platform. This represents a crowd-sourced competition to develop machine learning models trained on limited annotations to label single-cell protein patterns in fluorescent images. The particular challenges of this competition include class imbalance, weak labels and multi-label classification, prompting competitors to apply a wide range of approaches in their solutions. The winning models serve as the first subcellular omics tools that can annotate single-cell locations, extract single-cell features and capture cellular dynamics.
Izvorni jezik
Engleski
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
- Nature Index