Naslov
Schiff base derivatives as potential acetylcholinesterase inhibitors - an In vitro study

Autori
Šubarić, Domagoj ; Komar, Mario ; Karnaš, Maja ; Bešlo, Drago ; Rastija, Vesna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
19th Ružička Days Today science – tomorrow industry, Book of Abstracts / - , 2022, 125-125

Skup
19th Ružička Days Today science – tomorrow industry

Mjesto i datum
Vukovar, Hrvatska, 21-23.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Schiff base ; acetylcholinesterase ; inhibition

Sažetak
Schiff base derivatives were synthesized by utilizing the green chemistry methods such as microwave-assisted, ultrasound-assisted and mechanochemical synthesis. [1] Acetylcholinesterase inhibitors are widely recognised as potential drugs for treating symptoms of the Alzheimer's disease. Inhibitory properties of AChE inhibitors have been used for the developmet of active compounds in plant protection treatments. Twenty-four Schiff base derivatives were tested as potential acetylcholinesterase inhibitors. In vitro experiment has been conducted on a 96-well microplate UV-Vis reader by utilizing the modified Elmann's method. [2] Absorbance readings were obtained by measuring at the wavelenght of 412 nm. Donepezil was used as a standard acetylcholinesterase inhibitor. The highest percentage of inhibition was obtained with the compound 10 (Fig. 1), 34.58%, while the lowest inhibition percentage was obtained with compound 26 (3.88%).

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti

POVEZANOST RADA