Pregled bibliografske jedinice broj: 1234635
Multicomponent reaction derived small di- and tri- carbohydrate-based glycomimetics as tools for probing lectin specificity
Multicomponent reaction derived small di- and tri- carbohydrate-based glycomimetics as tools for probing lectin specificity // Glycoconjugate Journal, 39 (2022), 587-597 doi:10.1007/s10719-022-10079-3 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1234635 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Multicomponent reaction derived small di- and tri-
carbohydrate-based glycomimetics as tools for
probing lectin specificity
Autori
Jakas, Andreja ; Ayyalasomayajula, Ramya ; Cudic, Mare ; Jerić, Ivanka
Izvornik
Glycoconjugate Journal (0282-0080) 39
(2022);
587-597
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Carbohydrates ; Glycomimetics ; Lectins ; Passerini products ; Ugi products
Sažetak
Lectins, carbohydrate-binding proteins, play important functions in all forms of life from bacteria and viruses to plants, animals, and humans, participating in cell–cell communication and pathogen binding. In an attempt to modify lectin functions, artificial lectin ligands were made usually as big dendrimeric or cluster multivalent glycomimetic structures. Here we synthesized a novel set of glycomimetic ligands through protection/deprotection multicomponent reactions (MCR) approach. Multivalent di-and tri- carbohydrate glycomimetics containing D-fructose, D-galactose, and D-allose moieties were prepared in 63–96% yield. MCR glycomimetics demonstrated different binding abilities for plant lectins Con A and UEA I, and human galectin-3. Information gained about the influence of molecule structure, multivalency and optical purity on the lectin binding ability can be used in lectin detection and sensitivity measurements to further facilitate understanding of carbohydrate recognition process.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2014-09-3102 - Višekomponentne reakcije u sintezi peptidnih mimetika (MIMICRy) (Jerić, Ivanka, HRZZ - 2014-09) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
