Naslov
Heat shock proteins and their clinical relevance

Autori
Barišić, Karmela ; Kopić, Jasminka

Izvornik
Acta Pharmaceutica (1330-0075) 52 (2002), 2; 71-82

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
heat shock proteins; cytoskeleton; apoptosis; clinical relevance of heat shock proteins

Sažetak
Heat shock proteins (hsps) are some of the most phylogenetically conserved proteins. They are constitutively expressed under normal conditions, but their level increases when the cells are exposed to heat shock or other types of stress. Hsps are involved in some essential cell functions, such as protein translocation, folding and assembly, playing an important role in diverse biological processes, such as regulation of cytoskeletal structure, cell adhesion, migration, proliferation, cell death, antigen presentation and cell signaling. The cross-protection phenomenon of heat shock response is the basis for many potential medical applications of hsps, for example, for intervention in cardiovascular diseases or in organ preservation and transplantation. Since hsps are involved in immunological processes, they have a potential to be used in the development of immune system-based therapeutics targeted at cancer and autoimmune diseases.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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