Naslov
Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives

Autori
Kuna, Lucija ; Smolić, Robert ; Wu, Catherine H

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts: 7th Annual International Conference on Liver Diseases (7th AIC- Liver- 2022). / - Osijek, 2022

ISBN
978-953-8385-12-4

Skup
7th Annual International Conference on Liver Diseases (7th AIC- Liver 2022)

Mjesto i datum
Osijek, Hrvatska, 29.09.2022. - 01.10.2022

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
DILI, human hepatocytes cultures, liver tissue engineering, pluripotent stem cells

Sažetak
Drug-induced Liver Injury (DILI) is the most common cause of acute liver failure cases in the United States, and also one of the most frequently cited reason of withdrawal of drugs in both preclinical and clinical phases. DILI has been classified as direct (or intrinsic) and idiosyncratic. There are several models that can be useful for studying the mechanisms and pathophysiology of DILI: primary human hepatocytes cultures, cell lines derived from hepatic carcinoma, liver tissue engineering, human pluripotent stem cells derived hepatic cells and animal models. Despite tremendous effort and extensive research, prediction of DILI using in vitro and in vivo models remains very unreliable. The complex network of interactions among genetic, environmental, immune and metabolic factors behind DILI implies that its pathophysiological mechanisms cannot be recapitulated in a single study model. Therefore, the assumption is that addressing safety issues in drug development programs will also include more modeling modalities in the future. Substanital progress has been made in our understanding of DILI using different models, however considerable work remains to be elucidated.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA