Naslov
Deciphering the Complex Molecular Interplay in Health and Disease by Integrative Multi-omics

Autori
Horvatić, Anita

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts of the 1st Workshop on Mass Spectrometry in Life Sciences / Novak, Ruđer i sur. - Zagreb, 2022, 23-23

ISBN
978-953-6076-97-0

Skup
1st Workshop on Mass Spectrometry in Life Sciences

Mjesto i datum
Zagreb, Hrvatska, 24.11.2022. - 26.11.2022

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
proteomics, metabolomics, multi-omics, data integration, nutrition

Sažetak
The development of high-throughput omics methods and introduction of the systems biology approach revolutionized biomedical and nutritional research. The objective of any omics study is to characterize biomolecules and identify their networks and pathways which may play important roles in biological processes occurring in cell, tissue and/or organism. However, the biological interpretation of a single-layer omics data provides limited insights due to the complex biochemical regulation at multiple levels. The advances in technological innovations, sequencing technologies, increased computational power and bioinformatic tools, as well as introduction of publicly available databases enabled the emergence of integrated omics studies. Integrated multi- omics refers to comprehensive collection of large- scale datasets at multiple levels of information, combining genomics, transcriptomics, proteomics, metabolomics, lipidomics, glycomics, etc. These integrative approaches can provide detailed insights into the complex molecular mechanisms in health and disease. Mass spectrometry (MS) is one of the key analytical techniques on which the omics approaches are based, providing the detection and quantification of thousands of proteins and metabolites in a global or targeted manner. Herein, the application of integrative MS-based proteomics and metabolomics in pathological conditions and animal nutrition will be presented.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Veterinarska medicina, Biotehnologija

POVEZANOST RADA