Naslov
Intracranial hemangiopericytoma – can patients be safe from tumor recurrence?

Autori
Plečko, Valerija ; Pintarić, Karlo ; Perak, Eva ; Petrinović, Martina ; Peček, Mirta, Milanović, Matea ; Mrzljak, Anna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Skup
16th Croatian Student Summit

Mjesto i datum
Zagreb, Hrvatska, 09.12.2020. - 12.12.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
solitary fibrous tumor/hemangiopericytoma, metastases, radiotherapy, surgical resection

Sažetak
Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is an extremely rare mesenchymal tumor which arises from pericytes surrounding blood vessels, mostly in central nervous system. The treatment combines total resection with adjuvant radiotherapy with good results, however SFT/HPC tends to recur and develop distant metastases many years after surgical resection. In 2012 a 47-year old man presented with frontal headache, vision loss and changes in behavior and personality. Neuroradiological imaging showed a 7 cm expansive tumor in the left frontal lobe and the patient underwent total surgical resection. Histological analysis revealed grade III SFT/HPC with >10 mitosis per 10 high-power fields, proliferative activity Ki67 15% ; CD99 and CD34- positive, EMA- negative. The patient received adjuvant radiotherapy (60Gy/30x). For the next 8 years he was closely monitored with no signs of relapse on magnetic resonance, with unremarkable neurological status, except for partial but stable vision loss on both eyes. In 2020 an isoechogenic node (10 cm) was detected in the right liver lobe by ultrasound. MSCT showed a hypervascular lesion with central necrosis. Based on the histological similarity with the primary tumor, the lesion was confirmed to be a metastasis and the patient has been scheduled for liver resection. Due to rapid progression of high- grade SFT/HPC, early diagnosis and adequate treatment significantly improve patient outcomes. However, local and metastatic recurrence may occur years later despite the aggressive approach. Therefore, regular follow-up is strongly advised, as well as further studies which will help in defining the most effective treatment standard.(FIM) at discharge was 101/126, sphincter control and independent gait with normal speed was established. Cognitive function and voice quality were improved. Tetraparesis is a serious complication of encephalitis and CVT. This case shows the essence of physical therapy especially in terms of mobility and gaining muscle strength.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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