Naslov
Renal denervation evidence for uncontrolled resistant hypertension

Autori
Prkačin, Ingrid ; Jug, Juraj

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka / - , 2019

Skup
5. kongres nefrologa Bosne i Hercegovine

Mjesto i datum
Tuzla, Bosna i Hercegovina, 17.10.2019. - 20.10.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Recenziran

Ključne riječi
resistant hypertension, renal denervation, early changes

Sažetak
Introduction: Renal denervation has been shown to reduce office blood pressure and target organ damage in patients with resistant hypertension which diminishes cardiovascular mortality. We aimed to investigate the characteristics of early changes of blood pressure and proteinuria in resistant hypertension patients undergoing renal denervation. Methods: 15 patients have met criteria for renal denervation (Symplicity TM renal denervation system, 5F/6F quide catheter, five to seven nerve ablations of 100s duration were performed on each side without any complications – total mean 11). The blood pressure values obtained from 24h holter before the renal denervation was compared to those within one month after the procedure. Also the amount of excreted proteins in urine was measured and compared before and 3 months after renal denervation. 11 patients had no special anatomical constellations and 4 had changed anatomical constellations of renal arteries. None had multiple renal arteries on any side. All 15 patients were on the same medication six months after renal denervation. Results: All patients had chronic resistant hypertension more than 10 years with extremely high office values of blood pressure (min 190/120, max 300/180mmHg). The majority of patients were female (11 vs. 4) with an average age of 61 years (range 47-76years). Renal denervation procedure significantly reduced average 24h values of systolic (170.93 vs. 144.21mmHg, p<0.01, 15.63% reduction), diastolic blood pressure (100.92 vs. 85.93mmHg, p<0.05, 14.86% reduction) and MAP (124.26 vs. 105.36mmHg, p<0.01, 15.21% reduction). The amount of proteinuria showed a statistically insignificant decrease (0.43 vs. 0.16 g/l, p=0.16). Anatomical constellation did not showed any impact on overall decrease of blood pressure values. Conclusion: If sufficient renal sympathetic nerve ablation were performed and without changing of medication after the procedure, blood pressure values can be significantly reduced within one day to one month after renal denervation.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA